Strong's G5331: medication (“pharmacy”), that is, (by extension) magic (literal or figurative): - sorcery, witchcraft. G5332: a drug; that is a spell giving potion; a druggist (pharmacist) or poisoner; magician, sorcerer
I have questions about dopamine 2 receptors. D2 receptors presynaptic and postsynaptic inhibits dopamine release. And increased dopamine in mesolimbic pathway cause positive symptoms. I wonder why d2 antagonist reduces hyperactivity in this pathway and positive symptoms. I can't understand...
In mesolimbic pathway, the most dopaminergic neurons have mostly d2 receptors. In this pathway, due to the overacvation from glutamergic neurons, d2 receptors upregulated to inhibit the signal. But, in my opinion, it more than compensates the signal. The inhibition via mesolimbic pathway becomes so strong this time. So, we block some d2 receptors to excite mesolimbic pathway a little bit. Also antipsychotics don’t only block d2. It importantly also block 5HT2A excitatory receptors. So, we decrease the excitatory signal and find balance.
@@michelangelocaravaggio5018 thank you for your opinion I almost got it. I just wanna know the how d2 antagonist works in this pathway and at receptors but nobody tells me about this in Korea I think every worker in medical at mental hospital should know how works in brain
Bom dia, eu gostaria de saber, se suplementos de N-Acetil-L-Cisteína, se podem ajudar significafivamente pessoas com TOC refratário?
Strong's G5331: medication (“pharmacy”), that is, (by extension) magic (literal or figurative): - sorcery, witchcraft.
G5332: a drug; that is a spell giving potion; a druggist (pharmacist) or poisoner; magician, sorcerer
I have questions about dopamine 2 receptors.
D2 receptors presynaptic and postsynaptic inhibits dopamine release.
And increased dopamine in mesolimbic pathway cause positive symptoms.
I wonder why d2 antagonist reduces hyperactivity in this pathway and positive symptoms. I can't understand...
In mesolimbic pathway, the most dopaminergic neurons have mostly d2 receptors. In this pathway, due to the overacvation from glutamergic neurons, d2 receptors upregulated to inhibit the signal. But, in my opinion, it more than compensates the signal. The inhibition via mesolimbic pathway becomes so strong this time. So, we block some d2 receptors to excite mesolimbic pathway a little bit. Also antipsychotics don’t only block d2. It importantly also block 5HT2A excitatory receptors. So, we decrease the excitatory signal and find balance.
@@michelangelocaravaggio5018 thank you for your opinion I almost got it.
I just wanna know the how d2 antagonist works in this pathway and at receptors
but nobody tells me about this in Korea
I think every worker in medical at mental hospital should know how works in brain
Lamotrigine delete my ocd, after Years of High ssri