I am happy that I have an opportunity to work together with Dr. Notni's team on this project during my time at Technical University of Munich! This was a great journey! The teams of Prof. Kessler (TUM), Prof. Marinelli (Italy), Dr. Notni (TUM) created the model and used the computer prediction power to understand that the aminoacid sequence of the Ligand should look like a helix with x-RGDL-xx motion. Afterward, in the lab of Prof. Kessler, a large library of cyclic peptides was synthesized and investigated in vitro against avb6 Integrin and many others, which gave us a family of ligands with extremely high potential. Then, we joined efforts with Dr. Notni’s PET team and quipped one of the ligands as a proof-of-concept with TRAP-Ga fragment and went to animal studies Unfortunately, at that time, the pharmacokinetic was still not sufficiently enough But when another member of Ligand family was tested by Dr. Notni and Dr. Quigley this was successful and gave the tracer with huge application potential I am happy to see that my work does not lie on the shelf and will have opportunity to help people! I am excited to see next achievements of the program!
I am happy that I have an opportunity to work together with Dr. Notni's team on this project during my time at Technical University of Munich!
This was a great journey! The teams of Prof. Kessler (TUM), Prof. Marinelli (Italy), Dr. Notni (TUM) created the model and used the computer prediction power to understand that the aminoacid sequence of the Ligand should look like a helix with x-RGDL-xx motion.
Afterward, in the lab of Prof. Kessler, a large library of cyclic peptides was synthesized and investigated in vitro against avb6 Integrin and many others, which gave us a family of ligands with extremely high potential.
Then, we joined efforts with Dr. Notni’s PET team and quipped one of the ligands as a proof-of-concept with TRAP-Ga fragment and went to animal studies
Unfortunately, at that time, the pharmacokinetic was still not sufficiently enough
But when another member of Ligand family was tested by Dr. Notni and Dr. Quigley this was successful and gave the tracer with huge application potential
I am happy to see that my work does not lie on the shelf and will have opportunity to help people!
I am excited to see next achievements of the program!
Great achievement to the whole team.
Seems that your work laid the foundation for something with great potential.
Good fortune for your next projects and may they be just as promising!