I wish TED did more of those scientific talks instead of yet another "inspirational coaching" CRISPR is one viral thing, but how about EM "Impossible" Drive or Recent nano engine...They only seem to be center on AI recently with hosts saying same things over and over again.
Nik you're basically asking them to appeal to a niche audience and ignore other people's interest in things that are not scientific. I appreciateTED being an inclusive platform and providing a variety of subjects to understand.
Once the technology is out, no amount of laws, moratoriums, or policy will prevent it being worked on in every conceivable way, be it rats, rabbits or humans. I don't think it is an inherently bad thing, but no doubt terrible things will happen along the way, out of sight. It is absolutely inevitable.
Y'all, get on board with this technology. I'd like to see my Aunt's Huntington's disease completely eradicated. I see her suffer. There are more people like my aunt that need this DNA editing. Let's not get stuck on super babies and wooly mammoths. Those are petty subjects to those who have little time left to live. The philosophical conversations are critical to understanding but all the talk seems to stymie a potential miracle for someone looking at only a few months or years remaining. The subject makes my heart race with hope but the conversations of morality put dark spots in that hope.
Crisper can lead to the extinction of the human race. The genes pass forever. There’s no going back. Anyone who is edited with crisper should be immidiately steralised. We’ve caused extinction of entire mosquitos species with this tech. Anyone who has their genes edited - should never be allowed to breed ever again. In fact this tech is so dangerous - they should just stop. It’s not worth the risk to humanityZ
It's in all COVID vaccines, to edit the brain, why do you think the slogan of Karl Schwab was " you will have nothing and you will be happy"On his great reset COVID 19?
My mother's side of the family suffered from Huntingtons disease hopefully crispr will cure Huntington's disease I have Huntingtons disease praying for you
Science is hard work. There are people in their particular fields that make great contributions and never get recognized. To those people I would say thank you. You do the human race proud. Maybe you do it for the money, and/or fame, but you know what, if you're helping someone, that makes a difference. So again, thank you
Things like this have a tendency to simply disappear from the public discourse. Then 10 years later you’ll ask yourself, “hey, whatever happened to crispr?”
That's not how that works. In the real world Super powers like comic book heroes would come with EXTREMELY dangerous and destructive side effects. You want skin that can block bullets? Great, but good luck moving, weighing about a ton, and probably being in excruciating pain every time you DO manage to move. Like the best and probably safest super power that can be given with DNA editing is probably a significant immunity to a lot of diseases, reduced rate of aging, and.... Well we could make you glow in the dark, MAYBE but you probably won't be able to turn it off.
What I don't understand is, when Cas9 cuts the DNA, if it's only broken then shoving the two pieces together sounds right. If I'm mistaken and it cuts OUT a chunk, then I still don't quite grasp what the repair pathways have to do with anything. I did a bit of research, and I think the two pathways being discussed here are HR and NHEJ, but apparently homologous recombination, which is the supposedly more "interesting" repair pathway only occurs during meiosis. Other articles mention CRISPR being able to be applied to non-dividing cells that make up most adult tissue - which is quite obvious, or else it wouldn't be of much use to any living person - so that means it doesn't involve HR. So how does the cell respond when the DNA is cut? Or did I get the whole repair pathway thing wrong? When she said feed it a bit of DNA, does it mean to inject DNA and the cell just happens to find the piece lying around and use it to link the broken bits? Or was it carried with the cas9 protein? Also, apparently if you "blunt" the cutters of cas9, it makes the protein stay in place on the targeted gene and temporarily turns it off. How does that work? Really hope someone watching this knows a bit more about the topic than myself and can help me out a bit. Thanks internet. :)
I hope that lots of good will come of this. I'm concerned that making these genetic changes will be as if you are pushing at the tip of an iceberg without realizing that there's a mountain of ice below the ocean's surface that you can't see yet.
Sure but have you asked mother nature why did she created mosquitos in first place? What was her intension in the domino block building pyramid. If I remove mosquitos, yes birds could feed on ants but if that particular bird expertise on mosquito for 600 millions years, he might have a hard time to only eat ants, which are tricky to catch. Maybe the mating season of that bird coincide with mosquito season. It's like forcing every human on earth to adapt to vegetarism, it will work well for a particular human with blood type B, AB but those who are O+ might feel they get less energy and are less happy eating just veggies, am one of them. With thousands of years, that blood type may disapeared
oh to be perfect and healthy like you. At least you have the luxury of faith and ignorance. Us afflicted however look at the world pragmatic and with eyes open.
When it comes to CRISPR why is everybody going crazy about the wooly mammoth and blue eyes but nobody thinks about the lives it could save by curing diseases ? So excited for this. Imagine you can live happily with your family protected with an efficient healthcare. How peaceful.
I'm 14, and I'm trying to learn as much as I can about genetic engineering before University. If anyone knows of any articles or videos on CRISPR/Cas9 and genetically engineering/alteration please link them, I'd greatly appreciate any and all knowledge on the subject. Thank you!
She is right in that most of us work for a living ... just so that the few can play god. Monopolizing on great discovers using a 'Patent' defeats the whole premise of civilized Law. We need to modernize our collective thinking patterns to account for everyone on the planet ... their contribution and share in the rewards.
As a biotechnologist I think that while the patent mentality is unfortunately still prevalent, lots of us are moving towards an open collective mindset; from community bio-hack spaces, to open access journals and open source projects. The biotech community is becoming less corporate.
Vaughn Utube ah man, it does suck. But if X person puts in X amount of work, they should be rewarded. I do think the whole system needs an overhaul. I am not certain if genes that exist in nature or found later to exist should be patentable. Should the patent last so long? I don't have the answers, just the questions :)
Oh yeah I agree, if person X puts in the time they should be compensated for it. The problem is when he makes too much. Let say 1 billion for instance. They probably deserve it? ... but then every year after that, he'll make $300 million more or less just on interest alone. And so for generations ( or till the next war ) we'll be enslaved by these individuals just generating and protecting their growing wealth (and diminishing precious time we could have used discovering something else for the benefit of man/woman kind) ... it's stupid and we all need to put an end to it.
Patents are necessary; without them, incentive for innovation will be lower (Not gone, obviously, but do not underestimate the power of financial incentive). What is not necessary is for patents to become the brand protector for immortal companies, which is what they are now thanks to companies like Disney.
Stop with your playing god bullshit. Its fucking science. Go live In the forest and avoid all 'gods' inventions. Or better yet go to mid east where ppl pray all day.
Playing god, you think playing god is ok and that you wont open pandoras box.... you mess with DNA your gonna create something that will not be human anymore, something that could perhaps eat humans and have offspring without a partner.
@6:29 “The devil is in the details.” Very interesting choice of words. There are two types of tomatoes. Naturally grown and GMO (genetically modified organism) aka DNA 🧬 edited. The naturally grown tomato is a product of nature and is not owned by a corporate patent. However, GMO tomato is owned by a corporate patent. Think Monsanto. So the question is, if your DNA is edited by CRISPR technology, who will own you?
The quote is just an English proverb used to remind someone to pay attention to the details, used in a lot of poetry and literature. Regarding the ownership bit, the genetically engineered tomatoes have a patent because they’re commercially sold products, so ofc a company is going to put a patent on tomatoes that were genetically engineered to be better than others, thus potentially outselling any other tomato options available. If humans were to have diseases treated with CRISPR, then it would be a patent on the certain innovations regarding the technology itself (to prevent other competitive pharma companies from being able to use innovative mechanisms themselves), and not anyone who’s gotten those treatments. By the same thought thought process, people who have had certain vaccines would be owned by an entity due to certain vaccines, or parts of them being patented.
yes gene-editing is exciting. when the strand is broken or torn apart, as such, much like tearing an arm from your body, no matter how many surgeries you get, you cant "get back" to the "original form". this "tearing" event will always a probably in this process.
Not true in 2002 I was studying how they can regrow your arm or whatever you want as long as you have the DNA from the baby being born you could pay 3000 grand a month and cryogenic the belly button cord blood they pulled me out the room told me to never speak of it again or my son wouldn't be able to be born there. I gave other family's the info and they did it most rich. Js
When is crispr cast 9 in gene editing going to be available for people that have cancer or something like that and that's all they want to do is to cure it
Ellen says, "...It is the system that we stole from an ancient, ancient viral immune system." She sounds like she knows a lot of important details. How do viruses have ancient immiune systems? She has somehow spoken inaccurately, but to what is she referring to by "ancient, ancient viral immune system". I think she has informed us of something around for a very, very long time. Remember what ancient Spartans were said to do with babies that cried? - They were thrown to their deaths. It seems long ago people knew something strange about how babies have evolved into technical innovations of babies that is know being done with improving genetic engineering. Ellen seems to be speaking in a made up way, but she also seems partly enlightened.
This is such a great video. Amazing topic and I’m glad she is trying to break it down for the masses. We shouldn’t be trying to play with stuff like CRISPR, we should let the scientists do what they do best and if we want to support the research, donate money to labs working with CRISPR.
The title is very misleading. She only explained how CRISPR works and what the real cost and difficulty is. She didn't explain what impact it can have on our lives, which is by far the most important question for non-scientists. The other TED talk about CRISPR was much better: "Gene editing can now change an entire species -- forever"
All I've got to say is Einstein was right. We need to establish common ownership and democratic control of the collective product of our labour. CRISPR is a product of human labour. Turning it into a privately owned/sold commodity will turn its few owners into the rulers of the immense majority, the producers of the wealth of nations.
I suspect that Crispr will become so cheap that is can be done on a kitchen table. It just needs one person who believes it is possible. And that person will be backed by the entire human population, and they will make it free and accessible for all and everyone. This is inevitable.
while the good people who understand genetics are here I have a question , I hear about modifying genes as a future possibility how can you modify every DNA in every cell in the body of life organism . I understand how it can be done to embryos but how can it even be possible for a living organism ?? thanks
Because of cell division the modification spreads. Not a good technique for cells which don't multiple as much, like brain cell, muscles, etc But for those cases, we have just found a way to edit RNA using CRISPR and cas13.
same way, just more cells the virus has to enter, especially the targeted area needing treatment, liver, spine etc... i would imagine. Or even change the edit of our base stem cells so that production will be reflective of the new edited cell. But again im just spitballing.
We need to focus on self human evolution and environmentally helpful species strengthening so they can withstand our impact on this world. One day we can bring back extinct animals but for now we need to focus on our survival which is hanging half way off of a cliff
What effects would it (And future variations/advancements of it) have on living currently-existing creatures and humans? Like, if you CRISPR a live person to replace whatever genes control hair color, would their hair color slowly start to change because the default/natural state is now say black hair from blonde? Or something more extreme, could CRISPR be applied to transexuals? One of the more extreme but potentially possible examples (Compared to say turning humans into mutant ninja turtles or super soldiers). What are the boundaries of it?
*+Barenur* "We might never get to successfully editing live organisms after all" We already have. Its minor things but the question is more how far we can push it. My bet it really far by how things are looking atm. There are very few deal breakers as of yet.
Human experimentation is a must if you want to see real results in your lifetime. Millions of willing candidates world wide. It's peoples idea of morality is what stands in the way of real human advancement. Ignorant people.. their self righteous idiotic ideas stand in our way of progress.
It'd be a wonderful future to live in where you could take a pill and permanently alter features of yourself (Slowly over time as you grow into them), or make sure your child will grow up resistant to diseases or have vulnerabilities they would have had from your own genes removed. Couple that with stem sell research growing whole new organs and we'll be well on our way to mastering our physical existences. In another generation maybe we'll have nanomachines to fill in the gaps that are left and perhaps achieve an ageless lifespan.
Rarely on this page, they only post the higher quality ones (well researched and do not break guidelines like marketing a product in the talk). If you want to watch your friend's talk, you can search the Ted event on RUclips, e.g. TedX(place) or TedX (speaker name).
I don't understand. Why should Humanity be trusted to not use crisper recklessly or even maliciously? Even if it's only done one time the effect could be long-term and highly destructive. Humanity has many incentives to use it as a weapon and carelessly to satisfy our own selfish desires. I just don't understand why optimism and confidence are Almost Never accompanied by a blunt or honest discussion of the dangers. For example this presentation only addressed it as concerns about the unknown when it came to the dangers but when discussing the advantages OF CRISPR, she was more specific and thorough in comparison.
"How can we justify wiping out an entire species that we consider harmful to humans, off the face of the Earth?" You just answered your own question; the species is harmful.
parasites also play a large role within the web of life.. and the food chain, basic science man.. no matter how small it can have a large effect.. chaos theory, butterfly effect, things like that.. at the end of the day its a prey, predator and parasite relationship.. u cant eradicate a whole specie of tigers just coz they are wild and dangerous and can kill humans and other animals.. and that can mean eradicating the whole feline specie.. and humans also harm and threatens other species, we r the only specie that kills for fun.. not for survival
She's saying that this is a shared discovery because of the financial support for the biological sciences in Canada and the US. However, the story starts in Japan in 1987 with Yoshizumi Ishino and colleagues. Then off to the Netherlands in 1993. Then off to Alicante, Spain with Francisco Mojica at the University of Alicante. And so on ... Other countries support good science better than the US where for-profit corporations disrupt results, conclusions and availability.
crispr's major innovation is efficacy, there's nothing new about being able to edit DNA so I disagree with her premise that she needs to warn the general public about a function we've been able to do since the 90s
You're probably referring to Somatic genome editing, which only affects specific cells in an already living organism; Non-heritable changes that only live and die with that organism. She is referring to germline genome editing, which is done at the embryonic stage, affects every cell in the organism, and the edits pass on to the offspring.
Every technology has both good and bad potential effects, but unfortunately some people use it to their own vile desire and benefit harming a lot in the way. Many evils powerful people will certainly use it for bad purpose although our scientists aimed for the betterment of us. That's a fact and many will suffer and some will benefit too
She sounds like a very traditional person who is against and doubtful of innovation and change. “I don’t like it that the flashier aspects are drowning it out”???!! Keep your feelings out of it. It’s people like this that need to step aside and let a new generation in.
Claudeus Gothicus being immortal would be kinda boring eventually.. and it would only be cool if everyone around you was immortal.. and with how the human brain is I don't know how many humans will take pain from trauma that happens over and over again for eternity
I like all that I'm hearing, however, how long will CRISPR take before my Limb-girdle Muscular Dystrophy be treated and change for the better for my sake.
I'm at a crossroads point in my life .....I'm about to enroll into college and if anyone can help me decide as to whether or not to become a genetic engineer because of crispr.
Mohamed Umar don't be too concerned about picking the exact thing you should study. Pick a field that interests you now and get a broad understanding of as much as you can. If you want some good insight about how your career path will not be a straight line to a defined goal like "genetic engineer", Google "Steve Jobs commencement speech".
Pick something your interested in, not just because of a technique. Techniques come and go especially in science so as long as you have the drive and are interested in the field you will be fine.
To Mohammad Umar I made one big mistakes in my life, I persisted with that mistake, which was to choose a career that reward with money. You have the rest of your life for regret, choose something that is born In you, natural to you, even if your family and friends hate it.
I wish TED did more of those scientific talks instead of yet another "inspirational coaching"
CRISPR is one viral thing, but how about EM "Impossible" Drive or Recent nano engine...They only seem to be center on AI recently with hosts saying same things over and over again.
Yeah I do too... I see the inspirational coaching talks as filler really. TED is just another media publisher after all.
Easier to make money off inspiration speeches than it is anything based off intelligence
Ted is becoming what the history channel became: unrelated stuff
Nik you're basically asking them to appeal to a niche audience and ignore other people's interest in things that are not scientific. I appreciateTED being an inclusive platform and providing a variety of subjects to understand.
They are focusing on explained cutting edge science, not some half baked bullshit like the EM drive.
Once the technology is out, no amount of laws, moratoriums, or policy will prevent it being worked on in every conceivable way, be it rats, rabbits or humans. I don't think it is an inherently bad thing, but no doubt terrible things will happen along the way, out of sight. It is absolutely inevitable.
I know alot because of kurzgesagt
same they are brilliant
Thoughty2 and Vsauce for me.
And don't forget PBS Space Time!
In a nutshell
vsauce, thoughty2, kurzgesagt, and now TED
Y'all, get on board with this technology. I'd like to see my Aunt's Huntington's disease completely eradicated. I see her suffer. There are more people like my aunt that need this DNA editing. Let's not get stuck on super babies and wooly mammoths. Those are petty subjects to those who have little time left to live. The philosophical conversations are critical to understanding but all the talk seems to stymie a potential miracle for someone looking at only a few months or years remaining. The subject makes my heart race with hope but the conversations of morality put dark spots in that hope.
catherine lake +
mi mama tambien sufre de esta enfermedad
Crisper can lead to the extinction of the human race. The genes pass forever. There’s no going back. Anyone who is edited with crisper should be immidiately steralised. We’ve caused extinction of entire mosquitos species with this tech. Anyone who has their genes edited - should never be allowed to breed ever again.
In fact this tech is so dangerous - they should just stop. It’s not worth the risk to humanityZ
It's in all COVID vaccines, to edit the brain, why do you think the slogan of Karl Schwab was " you will have nothing and you will be happy"On his great reset COVID 19?
My mother's side of the family suffered from Huntingtons disease hopefully crispr will cure Huntington's disease I have Huntingtons disease praying for you
Science is hard work. There are people in their particular fields that make great contributions and never get recognized. To those people I would say thank you. You do the human race proud. Maybe you do it for the money, and/or fame, but you know what, if you're helping someone, that makes a difference. So again, thank you
It's staggering how far along technology has come in my life time. I couldn't imagine this technology as a child....
Were you a kid in the 90s? Because that's when covid was edited in a lab by a computer...
Lol, you probably have no idea it’s was used on you with the fake vax
It's been around they just don't tell the slaves they give you and I sports Hollywood entertainment.
I love how she summarized it all up into the final statement.
I've never heard of it but it sounds delicious.
I want crisper flavored cheez-its
Its kind of bummer to think my generation will be the last generation to NOT benefit from CRISPR..
Things like this have a tendency to simply disappear from the public discourse. Then 10 years later you’ll ask yourself, “hey, whatever happened to crispr?”
bhec7715 gets hidden
@@bhec7715 not CrisPr. Actually in progress.
SpinazFou
yeah...
2 years they said...
@@Samuel-qc7kg it's already used in eradicating rats in a US state. Well it was just approved. Lol
I love this. Dare I say a faster delivery. Superb delivery by the way. You ladies know how to speak. Thank you
thanks to kurzgesagt, i know what she's talking about... well most of it
LU39 samee
Exactly!
LU39 lol Same after watching that I watched another one and now I’m here
Me 2 they are amazing
I love Kurzgesagt
I want a mammoth steak but only if it's CRISPIER.
Don't give them any ideas. They'll bring mammoth back just to make it a menu item.
HigherPlanes sounds good to me
Eli Mager Why, though.
Yummo
@@HigherPlanes So be it.
yeah , yeah , just give me super powers ^^
The power of one extra chromosome.
Do you think that you really pour all of your super powers to fulfill it if you get it?
That's not how that works. In the real world Super powers like comic book heroes would come with EXTREMELY dangerous and destructive side effects. You want skin that can block bullets? Great, but good luck moving, weighing about a ton, and probably being in excruciating pain every time you DO manage to move. Like the best and probably safest super power that can be given with DNA editing is probably a significant immunity to a lot of diseases, reduced rate of aging, and.... Well we could make you glow in the dark, MAYBE but you probably won't be able to turn it off.
well faster regeneration and slow aging is good enough . i"ll have more time to practice my ninja skills . oh night vision may be very handy too :P
each of those possible superpowers would come with an enhanced cancer risk - do you want to end up like deadpool?
What I don't understand is, when Cas9 cuts the DNA, if it's only broken then shoving the two pieces together sounds right. If I'm mistaken and it cuts OUT a chunk, then I still don't quite grasp what the repair pathways have to do with anything. I did a bit of research, and I think the two pathways being discussed here are HR and NHEJ, but apparently homologous recombination, which is the supposedly more "interesting" repair pathway only occurs during meiosis. Other articles mention CRISPR being able to be applied to non-dividing cells that make up most adult tissue - which is quite obvious, or else it wouldn't be of much use to any living person - so that means it doesn't involve HR. So how does the cell respond when the DNA is cut? Or did I get the whole repair pathway thing wrong? When she said feed it a bit of DNA, does it mean to inject DNA and the cell just happens to find the piece lying around and use it to link the broken bits? Or was it carried with the cas9 protein? Also, apparently if you "blunt" the cutters of cas9, it makes the protein stay in place on the targeted gene and temporarily turns it off. How does that work? Really hope someone watching this knows a bit more about the topic than myself and can help me out a bit. Thanks internet. :)
I’m so excited for the future
Thank U and God bless U
I think we should bring back the wooly mammoth, but like a miniature one the size of a small dog
ᕕ( ᐛ )ᕗ I agree let’s make it happen
I have one, they've been around a while now
@@monajo855 if you don’t sin then Jesus died for nothing
Y'all go to Kurzgesagt it has the cutest animations and you really do pay attention to what the beautiful voice of a British man is saying ☺️
I hope that lots of good will come of this. I'm concerned that making these genetic changes will be as if you are pushing at the tip of an iceberg without realizing that there's a mountain of ice below the ocean's surface that you can't see yet.
Thank you for this educational video!
1:43 - "That's how it works" ....... Nice graphic animation of how CRISPR works.
I feel like this is a really interesting thing but very very dangerous due to mistakes or people weaponizing it.
wipe out the goddamn mosquitoes
just need one guy to do it without telling anyone and then its too late - what are they going kill all the GM mosquitoes HaHa.
Who will feed the birds and the spiders?
Alberto Humova the other insects.
we should wipe out plasmodium. mosquitoes also suffer from malaria.
Sure but have you asked mother nature why did she created mosquitos in first place? What was her intension in the domino block building pyramid. If I remove mosquitos, yes birds could feed on ants but if that particular bird expertise on mosquito for 600 millions years, he might have a hard time to only eat ants, which are tricky to catch. Maybe the mating season of that bird coincide with mosquito season.
It's like forcing every human on earth to adapt to vegetarism, it will work well for a particular human with blood type B, AB but those who are O+ might feel they get less energy and are less happy eating just veggies, am one of them. With thousands of years, that blood type may disapeared
She is so real i love it
It's not a coincidence that she said the devil is in the details....and that's very scary
Hannah Reid I noticed that too. Also, the fact that she said you can stuff extras in and she said "kind of like a Trojan horse"...
oh to be perfect and healthy like you. At least you have the luxury of faith and ignorance. Us afflicted however look at the world pragmatic and with eyes open.
@@No1More1Mr1Nice1Guy1 But you can't approach the word with openness of mind?
@@demetriusflenory2385 i suspect we differ greatly on our interpretations of 'openness of mind'
@@No1More1Mr1Nice1Guy1 Indeed
Will this work for a living adult?
Excellent talk on a new discovery.
When it comes to CRISPR why is everybody going crazy about the wooly mammoth and blue eyes but nobody thinks about the lives it could save by curing diseases ? So excited for this. Imagine you can live happily with your family protected with an efficient healthcare. How peaceful.
Crispr can eradicate entire species. It’s somewhat dangerous and needs regulation
Great storytelling!
I'm 14, and I'm trying to learn as much as I can about genetic engineering before University. If anyone knows of any articles or videos on CRISPR/Cas9 and genetically engineering/alteration please link them, I'd greatly appreciate any and all knowledge on the subject. Thank you!
Good luck!
Use the internet dumbass
Read 'A crack in creation' Book
I think watching videos like these first will build base knowledge and then you can go futher in depth with text books or courses etc. Gl.
You can read this Research Paper entitled Cas 9 as a versatile tool for engineering biology by Prashant Mali, kevin MEsvelt and George M Church
But I'm the best life form.
Chuck Norris ... is it true that you never cry but instead sweat from the eyes?
lmao!
eugenics is a weapon. always has been always will be
Everything can be a weapon
She is right in that most of us work for a living ... just so that the few can play god. Monopolizing on great discovers using a 'Patent' defeats the whole premise of civilized Law. We need to modernize our collective thinking patterns to account for everyone on the planet ... their contribution and share in the rewards.
As a biotechnologist I think that while the patent mentality is unfortunately still prevalent, lots of us are moving towards an open collective mindset; from community bio-hack spaces, to open access journals and open source projects. The biotech community is becoming less corporate.
Vaughn Utube ah man, it does suck. But if X person puts in X amount of work, they should be rewarded. I do think the whole system needs an overhaul. I am not certain if genes that exist in nature or found later to exist should be patentable. Should the patent last so long? I don't have the answers, just the questions :)
Oh yeah I agree, if person X puts in the time they should be compensated for it. The problem is when he makes too much. Let say 1 billion for instance. They probably deserve it? ... but then every year after that, he'll make $300 million more or less just on interest alone. And so for generations ( or till the next war ) we'll be enslaved by these individuals just generating and protecting their growing wealth (and diminishing precious time we could have used discovering something else for the benefit of man/woman kind) ... it's stupid and we all need to put an end to it.
Patents are necessary; without them, incentive for innovation will be lower (Not gone, obviously, but do not underestimate the power of financial incentive). What is not necessary is for patents to become the brand protector for immortal companies, which is what they are now thanks to companies like Disney.
Stop with your playing god bullshit. Its fucking science. Go live In the forest and avoid all 'gods' inventions. Or better yet go to mid east where ppl pray all day.
I know from experience that humans have a great way of taking great things and turning them into nightmares
Yes just look at what they're doing with it now lol
"You need a lab"
-So does Meth
Meth doesn't need a lab.
oh okay then good point Kellen Ruppee says no lab required everyone I guess that's that.
@@eattoast6378 Mind you that this technology is so basic even morons like Kellen will have access to it.
@@Abraxis86 You said meth needs a lab. I said meth does not need a lab. Why does this upset you? I didn't insult you.
Playing god, you think playing god is ok and that you wont open pandoras box.... you mess with DNA your gonna create something that will not be human anymore, something that could perhaps eat humans and have offspring without a partner.
@6:29 “The devil is in the details.” Very interesting choice of words.
There are two types of tomatoes. Naturally grown and GMO (genetically modified organism) aka DNA 🧬 edited.
The naturally grown tomato is a product of nature and is not owned by a corporate patent.
However, GMO tomato is owned by a corporate patent. Think Monsanto.
So the question is, if your DNA is edited by CRISPR technology, who will own you?
C19 has allowed 90% of people to be MRNA edited
The quote is just an English proverb used to remind someone to pay attention to the details, used in a lot of poetry and literature.
Regarding the ownership bit, the genetically engineered tomatoes have a patent because they’re commercially sold products, so ofc a company is going to put a patent on tomatoes that were genetically engineered to be better than others, thus potentially outselling any other tomato options available.
If humans were to have diseases treated with CRISPR, then it would be a patent on the certain innovations regarding the technology itself (to prevent other competitive pharma companies from being able to use innovative mechanisms themselves), and not anyone who’s gotten those treatments.
By the same thought thought process, people who have had certain vaccines would be owned by an entity due to certain vaccines, or parts of them being patented.
@@anthonydo9945 Have you researched what’s in these CV-19 vaccines?
I think CRISPR deserved a better presentation.
Azureim yess this speech and speaker were a bit dull. If you haven’t already watch this, search up “CRISPR in a nutshell”
Buy the dip
The genome is eccectric
yes gene-editing is exciting. when the strand is broken or torn apart, as such, much like tearing an arm from your body, no matter how many surgeries you get, you cant "get back" to the "original form". this "tearing" event will always a probably in this process.
Not true in 2002 I was studying how they can regrow your arm or whatever you want as long as you have the DNA from the baby being born you could pay 3000 grand a month and cryogenic the belly button cord blood they pulled me out the room told me to never speak of it again or my son wouldn't be able to be born there. I gave other family's the info and they did it most rich. Js
和訳ありがとうございます。とても勉強になります。
Anyone who is worried about CRISPR needs to consider what government has done to people.
Add a dose of 5g and call us done.
"u cant just do this in your kitchen" as im doing my crispr experiments in my kitchen
Ellen! Your hair is stuck you the mic!
Amazing an scary at the same time. In love with technology!!!!
marry it then
5ya!!!
Crisper. Eugenics.
Genetic engineering.
When is crispr cast 9 in gene editing going to be available for people that have cancer or something like that and that's all they want to do is to cure it
"How can we justify wiping an entire species that is harmful to humans off the face of the planet?" That question answers itself.
Thanks dear for such a beautiful explaination
At times my back hurts. Is it possible too... with CRISPR??? O.o
Ellen says, "...It is the system that we stole from an ancient, ancient viral immune system." She sounds like she knows a lot of important details. How do viruses have ancient immiune systems? She has somehow spoken inaccurately, but to what is she referring to by "ancient, ancient viral immune system". I think she has informed us of something around for a very, very long time. Remember what ancient Spartans were said to do with babies that cried? - They were thrown to their deaths. It seems long ago people knew something strange about how babies have evolved into technical innovations of babies that is know being done with improving genetic engineering. Ellen seems to be speaking in a made up way, but she also seems partly enlightened.
This is such a great video. Amazing topic and I’m glad she is trying to break it down for the masses. We shouldn’t be trying to play with stuff like CRISPR, we should let the scientists do what they do best and if we want to support the research, donate money to labs working with CRISPR.
6:30 Do we need to know all these reasons why. It's better to classify wich one does what. Eventually the reasons why will become clear.
And the money grubbing beat goes on. ...
I expected to learn more
Patent a technology when there are so many unknown consequences ? Seriously 😶
I am kind of wondering if any natural disease mechanisms were able to utilize Cas9 or similar sequences...prior to the patent filings.
Awesome Explanation mam😊
The title is very misleading. She only explained how CRISPR works and what the real cost and difficulty is. She didn't explain what impact it can have on our lives, which is by far the most important question for non-scientists.
The other TED talk about CRISPR was much better: "Gene editing can now change an entire species -- forever"
she is there to confuse people more, and let them think that is very god/positiv using CRISPR!!!!! She is scient.
the kurzgesagt is best channel on youtube
All I've got to say is Einstein was right. We need to establish common ownership and democratic control of the collective product of our labour. CRISPR is a product of human labour. Turning it into a privately owned/sold commodity will turn its few owners into the rulers of the immense majority, the producers of the wealth of nations.
Dammit Jim! It’s OK Dr. McCoy
The anthropomorphization really helped me understand
Very nice talk
I suspect that Crispr will become so cheap that is can be done on a kitchen table. It just needs one person who believes it is possible. And that person will be backed by the entire human population, and they will make it free and accessible for all and everyone. This is inevitable.
Can we reverse aging?
awesome!
@@danishajaib1923 yes but it's hard and will take alotta time
No we cannot. Not significantly but crispr scientist are working on this. Look up David Sinclair he's a geneologist for that study.
while the good people who understand genetics are here I have a question , I hear about modifying genes as a future possibility how can you modify every DNA in every cell in the body of life organism . I understand how it can be done to embryos but how can it even be possible for a living organism ?? thanks
last shadow By using viruses that infect your organism, as she said it's not easy.
Because of cell division the modification spreads. Not a good technique for cells which don't multiple as much, like brain cell, muscles, etc But for those cases, we have just found a way to edit RNA using CRISPR and cas13.
same way, just more cells the virus has to enter, especially the targeted area needing treatment, liver, spine etc... i would imagine. Or even change the edit of our base stem cells so that production will be reflective of the new edited cell. But again im just spitballing.
Meowwolf anyone?
Genetic engineering should NOT be patented
We need to focus on self human evolution and environmentally helpful species strengthening so they can withstand our impact on this world. One day we can bring back extinct animals but for now we need to focus on our survival which is hanging half way off of a cliff
on our road to make Frankenstein :)) its awesome
What effects would it (And future variations/advancements of it) have on living currently-existing creatures and humans? Like, if you CRISPR a live person to replace whatever genes control hair color, would their hair color slowly start to change because the default/natural state is now say black hair from blonde? Or something more extreme, could CRISPR be applied to transexuals? One of the more extreme but potentially possible examples (Compared to say turning humans into mutant ninja turtles or super soldiers).
What are the boundaries of it?
*+Barenur* "We might never get to successfully editing live organisms after all"
We already have. Its minor things but the question is more how far we can push it.
My bet it really far by how things are looking atm. There are very few deal breakers as of yet.
Human experimentation is a must if you want to see real results in your lifetime. Millions of willing candidates world wide. It's peoples idea of morality is what stands in the way of real human advancement. Ignorant people.. their self righteous idiotic ideas stand in our way of progress.
What Whatwhat
I agree.
Hopefully they wont choose for all of us
It'd be a wonderful future to live in where you could take a pill and permanently alter features of yourself (Slowly over time as you grow into them), or make sure your child will grow up resistant to diseases or have vulnerabilities they would have had from your own genes removed. Couple that with stem sell research growing whole new organs and we'll be well on our way to mastering our physical existences. In another generation maybe we'll have nanomachines to fill in the gaps that are left and perhaps achieve an ageless lifespan.
Kate Apples
That's only 10-15 years away at this rate of progress though. And that might be a conservative estimate on my part.
At least partly.
This was like watching someone give a talk about Napster in 1998
Why are religious people against this?
Because they are too blinded by their superstitious mind...
Hooray, Eugenics is cool again!
What is the success rate?
Really amazing lecture, than you.
my friend had a ted talk this weekend, when do ted talks usually get posted
Rarely on this page, they only post the higher quality ones (well researched and do not break guidelines like marketing a product in the talk). If you want to watch your friend's talk, you can search the Ted event on RUclips, e.g. TedX(place) or TedX (speaker name).
Michael Rosche hm still can't find it so idk
SharkmasterD Then they havn't posted it, try facebook.
Any iGEMers here? Heard quite enough about CRISPR for a little while... xD
Not IGEMer but using CRISPR almost every day ;-)
Can It change hair texture?
I don't understand. Why should Humanity be trusted to not use crisper recklessly or even maliciously? Even if it's only done one time the effect could be long-term and highly destructive. Humanity has many incentives to use it as a weapon and carelessly to satisfy our own selfish desires. I just don't understand why optimism and confidence are Almost Never accompanied by a blunt or honest discussion of the dangers. For example this presentation only addressed it as concerns about the unknown when it came to the dangers but when discussing the advantages OF CRISPR, she was more specific and thorough in comparison.
She's right there devil is in this detail. Leave the creating to the Creator not fallen human being.
"How can we justify wiping out an entire species that we consider harmful to humans, off the face of the Earth?"
You just answered your own question; the species is harmful.
parasites also play a large role within the web of life.. and the food chain, basic science man.. no matter how small it can have a large effect.. chaos theory, butterfly effect, things like that..
at the end of the day its a prey, predator and parasite relationship.. u cant eradicate a whole specie of tigers just coz they are wild and dangerous and can kill humans and other animals.. and that can mean eradicating the whole feline specie..
and humans also harm and threatens other species, we r the only specie that kills for fun.. not for survival
Don’t want to sound edgy butttttt “I am become death, destroyer of worlds” Now........ die despasquitos 😂
Well, that would disturb the environmental cycle or the food chain resulting in some severe consequences...
humans are harmful to so many species and I don't see anyone inventing tech that can wipe us off the face of Earth
@@mitalilal6215 wow?? You must not love yourself. Sad
She's saying that this is a shared discovery because of the financial support for the biological sciences in Canada and the US. However, the story starts in Japan in 1987 with Yoshizumi Ishino and colleagues. Then off to the Netherlands in 1993.
Then off to Alicante, Spain with Francisco Mojica at the University of Alicante. And so on ... Other countries support good science better than the US where for-profit corporations disrupt results, conclusions and availability.
5:41 oh ya? what if I like to do it on kitchen table...
I want to work with these things. What do I need to study?
2 words, space marines
crispr's major innovation is efficacy, there's nothing new about being able to edit DNA so I disagree with her premise that she needs to warn the general public about a function we've been able to do since the 90s
You're probably referring to Somatic genome editing, which only affects specific cells in an already living organism; Non-heritable changes that only live and die with that organism. She is referring to germline genome editing, which is done at the embryonic stage, affects every cell in the organism, and the edits pass on to the offspring.
Every technology has both good and bad potential effects, but unfortunately some people use it to their own vile desire and benefit harming a lot in the way. Many evils powerful people will certainly use it for bad purpose although our scientists aimed for the betterment of us. That's a fact and many will suffer and some will benefit too
You don't need a professional lab, you just need the equipment and necessary skill
She sounds like a very traditional person who is against and doubtful of innovation and change. “I don’t like it that the flashier aspects are drowning it out”???!! Keep your feelings out of it. It’s people like this that need to step aside and let a new generation in.
there's one quastion ib my mind. If we use SCISPR-CAS in human body, will our immune system react to foreign protein CAS9?
"Adaptation Is a sigh of Intelligence"... Well, this relationship is more close that I thought.
gimme imortality.
In my opinion those who desire immortality.. are the very people who should not have it..
Claudeus Gothicus being immortal would be kinda boring eventually.. and it would only be cool if everyone around you was immortal.. and with how the human brain is I don't know how many humans will take pain from trauma that happens over and over again for eternity
But why is it 20 base pairs on the RNA instead of 21? How could a stop codon work if the anticodon can't bond?
Wtf....Licensing issues here we are. I really hate corporate entities. Just like google and apple.
about the Wooly mammoth: currently the climatic conditions might not be good for that. if the new ice age will appear, the chances might be higher ;P
Watch the movie 'Gattica'
I like all that I'm hearing, however, how long will CRISPR take before my Limb-girdle Muscular Dystrophy be treated and change for the better for my sake.
I'm at a crossroads point in my life .....I'm about to enroll into college and if anyone can help me decide as to whether or not to become a genetic engineer because of crispr.
When you finish you degree this tech is going to be outdated and HATED by people. Good luck!
***** similarly with GMO. "NOBODY" wants "new GMOs" (plants or animals).
Mohamed Umar don't be too concerned about picking the exact thing you should study. Pick a field that interests you now and get a broad understanding of as much as you can. If you want some good insight about how your career path will not be a straight line to a defined goal like "genetic engineer", Google "Steve Jobs commencement speech".
Pick something your interested in, not just because of a technique. Techniques come and go especially in science so as long as you have the drive and are interested in the field you will be fine.
To Mohammad Umar
I made one big mistakes in my life, I persisted with that mistake, which was to choose a career that reward with money.
You have the rest of your life for regret, choose something that is born In you, natural to you, even if your family and friends hate it.