What you need to know about CRISPR | Ellen Jorgensen
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- Опубликовано: 25 май 2024
- Should we bring back the wooly mammoth? Or edit a human embryo? Or wipe out an entire species that we consider harmful? The genome-editing technology CRISPR has made extraordinary questions like these legitimate - but how does it work? Scientist and community lab advocate Ellen Jorgensen is on a mission to explain the myths and realities of CRISPR, hype-free, to the non-scientists among us.
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I wish TED did more of those scientific talks instead of yet another "inspirational coaching"
CRISPR is one viral thing, but how about EM "Impossible" Drive or Recent nano engine...They only seem to be center on AI recently with hosts saying same things over and over again.
Yeah I do too... I see the inspirational coaching talks as filler really. TED is just another media publisher after all.
Easier to make money off inspiration speeches than it is anything based off intelligence
Ted is becoming what the history channel became: unrelated stuff
Nik you're basically asking them to appeal to a niche audience and ignore other people's interest in things that are not scientific. I appreciateTED being an inclusive platform and providing a variety of subjects to understand.
They are focusing on explained cutting edge science, not some half baked bullshit like the EM drive.
Once the technology is out, no amount of laws, moratoriums, or policy will prevent it being worked on in every conceivable way, be it rats, rabbits or humans. I don't think it is an inherently bad thing, but no doubt terrible things will happen along the way, out of sight. It is absolutely inevitable.
Y'all, get on board with this technology. I'd like to see my Aunt's Huntington's disease completely eradicated. I see her suffer. There are more people like my aunt that need this DNA editing. Let's not get stuck on super babies and wooly mammoths. Those are petty subjects to those who have little time left to live. The philosophical conversations are critical to understanding but all the talk seems to stymie a potential miracle for someone looking at only a few months or years remaining. The subject makes my heart race with hope but the conversations of morality put dark spots in that hope.
catherine lake +
mi mama tambien sufre de esta enfermedad
Crisper can lead to the extinction of the human race. The genes pass forever. There’s no going back. Anyone who is edited with crisper should be immidiately steralised. We’ve caused extinction of entire mosquitos species with this tech. Anyone who has their genes edited - should never be allowed to breed ever again.
In fact this tech is so dangerous - they should just stop. It’s not worth the risk to humanityZ
It's in all COVID vaccines, to edit the brain, why do you think the slogan of Karl Schwab was " you will have nothing and you will be happy"On his great reset COVID 19?
My mother's side of the family suffered from Huntingtons disease hopefully crispr will cure Huntington's disease I have Huntingtons disease praying for you
Science is hard work. There are people in their particular fields that make great contributions and never get recognized. To those people I would say thank you. You do the human race proud. Maybe you do it for the money, and/or fame, but you know what, if you're helping someone, that makes a difference. So again, thank you
I know alot because of kurzgesagt
same they are brilliant
Thoughty2 and Vsauce for me.
And don't forget PBS Space Time!
In a nutshell
vsauce, thoughty2, kurzgesagt, and now TED
It's staggering how far along technology has come in my life time. I couldn't imagine this technology as a child....
Were you a kid in the 90s? Because that's when covid was edited in a lab by a computer...
Lol, you probably have no idea it’s was used on you with the fake vax
It's been around they just don't tell the slaves they give you and I sports Hollywood entertainment.
I love how she summarized it all up into the final statement.
I love this. Dare I say a faster delivery. Superb delivery by the way. You ladies know how to speak. Thank you
I want a mammoth steak but only if it's CRISPIER.
Don't give them any ideas. They'll bring mammoth back just to make it a menu item.
HigherPlanes sounds good to me
Eli Mager Why, though.
Yummo
@@HigherPlanes So be it.
Thank you for this educational video!
Thanks dear for such a beautiful explaination
I've never heard of it but it sounds delicious.
I want crisper flavored cheez-its
Its kind of bummer to think my generation will be the last generation to NOT benefit from CRISPR..
Things like this have a tendency to simply disappear from the public discourse. Then 10 years later you’ll ask yourself, “hey, whatever happened to crispr?”
bhec7715 gets hidden
@@bhec7715 not CrisPr. Actually in progress.
SpinazFou
yeah...
2 years they said...
@@Samuel-qc7kg it's already used in eradicating rats in a US state. Well it was just approved. Lol
I’m so excited for the future
Excellent talk on a new discovery.
Great storytelling!
Really amazing lecture, than you.
Awesome Explanation mam😊
Very nice talk
yeah , yeah , just give me super powers ^^
The power of one extra chromosome.
Do you think that you really pour all of your super powers to fulfill it if you get it?
That's not how that works. In the real world Super powers like comic book heroes would come with EXTREMELY dangerous and destructive side effects. You want skin that can block bullets? Great, but good luck moving, weighing about a ton, and probably being in excruciating pain every time you DO manage to move. Like the best and probably safest super power that can be given with DNA editing is probably a significant immunity to a lot of diseases, reduced rate of aging, and.... Well we could make you glow in the dark, MAYBE but you probably won't be able to turn it off.
well faster regeneration and slow aging is good enough . i"ll have more time to practice my ninja skills . oh night vision may be very handy too :P
each of those possible superpowers would come with an enhanced cancer risk - do you want to end up like deadpool?
thanks to kurzgesagt, i know what she's talking about... well most of it
LU39 samee
Exactly!
LU39 lol Same after watching that I watched another one and now I’m here
Me 2 they are amazing
I love Kurzgesagt
I think we should bring back the wooly mammoth, but like a miniature one the size of a small dog
ᕕ( ᐛ )ᕗ I agree let’s make it happen
I have one, they've been around a while now
@@monajo855 if you don’t sin then Jesus died for nothing
What I don't understand is, when Cas9 cuts the DNA, if it's only broken then shoving the two pieces together sounds right. If I'm mistaken and it cuts OUT a chunk, then I still don't quite grasp what the repair pathways have to do with anything. I did a bit of research, and I think the two pathways being discussed here are HR and NHEJ, but apparently homologous recombination, which is the supposedly more "interesting" repair pathway only occurs during meiosis. Other articles mention CRISPR being able to be applied to non-dividing cells that make up most adult tissue - which is quite obvious, or else it wouldn't be of much use to any living person - so that means it doesn't involve HR. So how does the cell respond when the DNA is cut? Or did I get the whole repair pathway thing wrong? When she said feed it a bit of DNA, does it mean to inject DNA and the cell just happens to find the piece lying around and use it to link the broken bits? Or was it carried with the cas9 protein? Also, apparently if you "blunt" the cutters of cas9, it makes the protein stay in place on the targeted gene and temporarily turns it off. How does that work? Really hope someone watching this knows a bit more about the topic than myself and can help me out a bit. Thanks internet. :)
Fantastic!
This reminds me of some of the missions in the show travelers
和訳ありがとうございます。とても勉強になります。
I am kind of wondering if any natural disease mechanisms were able to utilize Cas9 or similar sequences...prior to the patent filings.
Thank U and God bless U
I hope that lots of good will come of this. I'm concerned that making these genetic changes will be as if you are pushing at the tip of an iceberg without realizing that there's a mountain of ice below the ocean's surface that you can't see yet.
1:43 - "That's how it works" ....... Nice graphic animation of how CRISPR works.
When it comes to CRISPR why is everybody going crazy about the wooly mammoth and blue eyes but nobody thinks about the lives it could save by curing diseases ? So excited for this. Imagine you can live happily with your family protected with an efficient healthcare. How peaceful.
Crispr can eradicate entire species. It’s somewhat dangerous and needs regulation
She is so real i love it
Y'all go to Kurzgesagt it has the cutest animations and you really do pay attention to what the beautiful voice of a British man is saying ☺️
I feel like this is a really interesting thing but very very dangerous due to mistakes or people weaponizing it.
The anthropomorphization really helped me understand
Nice video. Keep it up
"u cant just do this in your kitchen" as im doing my crispr experiments in my kitchen
6:30 Do we need to know all these reasons why. It's better to classify wich one does what. Eventually the reasons why will become clear.
I'm 14, and I'm trying to learn as much as I can about genetic engineering before University. If anyone knows of any articles or videos on CRISPR/Cas9 and genetically engineering/alteration please link them, I'd greatly appreciate any and all knowledge on the subject. Thank you!
Good luck!
Use the internet dumbass
Read 'A crack in creation' Book
I think watching videos like these first will build base knowledge and then you can go futher in depth with text books or courses etc. Gl.
You can read this Research Paper entitled Cas 9 as a versatile tool for engineering biology by Prashant Mali, kevin MEsvelt and George M Church
wipe out the goddamn mosquitoes
just need one guy to do it without telling anyone and then its too late - what are they going kill all the GM mosquitoes HaHa.
Who will feed the birds and the spiders?
Alberto Humova the other insects.
we should wipe out plasmodium. mosquitoes also suffer from malaria.
Sure but have you asked mother nature why did she created mosquitos in first place? What was her intension in the domino block building pyramid. If I remove mosquitos, yes birds could feed on ants but if that particular bird expertise on mosquito for 600 millions years, he might have a hard time to only eat ants, which are tricky to catch. Maybe the mating season of that bird coincide with mosquito season.
It's like forcing every human on earth to adapt to vegetarism, it will work well for a particular human with blood type B, AB but those who are O+ might feel they get less energy and are less happy eating just veggies, am one of them. With thousands of years, that blood type may disapeared
Amazing an scary at the same time. In love with technology!!!!
marry it then
It's not a coincidence that she said the devil is in the details....and that's very scary
Hannah Reid I noticed that too. Also, the fact that she said you can stuff extras in and she said "kind of like a Trojan horse"...
oh to be perfect and healthy like you. At least you have the luxury of faith and ignorance. Us afflicted however look at the world pragmatic and with eyes open.
@@No1More1Mr1Nice1Guy1 But you can't approach the word with openness of mind?
@@demetriusflenory2385 i suspect we differ greatly on our interpretations of 'openness of mind'
@@No1More1Mr1Nice1Guy1 Indeed
Dammit Jim! It’s OK Dr. McCoy
But why is it 20 base pairs on the RNA instead of 21? How could a stop codon work if the anticodon can't bond?
on our road to make Frankenstein :)) its awesome
5:41 oh ya? what if I like to do it on kitchen table...
Interesting.
When is crispr cast 9 in gene editing going to be available for people that have cancer or something like that and that's all they want to do is to cure it
This was like watching someone give a talk about Napster in 1998
Will this work for a living adult?
"How can we justify wiping an entire species that is harmful to humans off the face of the planet?" That question answers itself.
"You need a lab"
-So does Meth
Meth doesn't need a lab.
oh okay then good point Kellen Ruppee says no lab required everyone I guess that's that.
@@eattoast6378 Mind you that this technology is so basic even morons like Kellen will have access to it.
@@Abraxis86 You said meth needs a lab. I said meth does not need a lab. Why does this upset you? I didn't insult you.
Playing god, you think playing god is ok and that you wont open pandoras box.... you mess with DNA your gonna create something that will not be human anymore, something that could perhaps eat humans and have offspring without a partner.
At times my back hurts. Is it possible too... with CRISPR??? O.o
Descubierto por un español, y no esta traducido al español. que hay que hacer para traducirlo?
Anyone who is worried about CRISPR needs to consider what government has done to people.
Add a dose of 5g and call us done.
I want to work with these things. What do I need to study?
I expected to learn more
my friend had a ted talk this weekend, when do ted talks usually get posted
Rarely on this page, they only post the higher quality ones (well researched and do not break guidelines like marketing a product in the talk). If you want to watch your friend's talk, you can search the Ted event on RUclips, e.g. TedX(place) or TedX (speaker name).
Michael Rosche hm still can't find it so idk
SharkmasterD Then they havn't posted it, try facebook.
1:54 That sounds a little more like a Chain-Chom lol
But I'm the best life form.
Chuck Norris ... is it true that you never cry but instead sweat from the eyes?
lmao!
I know from experience that humans have a great way of taking great things and turning them into nightmares
Yes just look at what they're doing with it now lol
there's one quastion ib my mind. If we use SCISPR-CAS in human body, will our immune system react to foreign protein CAS9?
I think CRISPR deserved a better presentation.
Azureim yess this speech and speaker were a bit dull. If you haven’t already watch this, search up “CRISPR in a nutshell”
Someone please put her the sunglasses 9:43
I take my hat off with that last minutes...
What do you know about phenotypic revolutions?
I want to take this therepy/ treatment pl
Ellen says, "...It is the system that we stole from an ancient, ancient viral immune system." She sounds like she knows a lot of important details. How do viruses have ancient immiune systems? She has somehow spoken inaccurately, but to what is she referring to by "ancient, ancient viral immune system". I think she has informed us of something around for a very, very long time. Remember what ancient Spartans were said to do with babies that cried? - They were thrown to their deaths. It seems long ago people knew something strange about how babies have evolved into technical innovations of babies that is know being done with improving genetic engineering. Ellen seems to be speaking in a made up way, but she also seems partly enlightened.
Can It change hair texture?
She is right in that most of us work for a living ... just so that the few can play god. Monopolizing on great discovers using a 'Patent' defeats the whole premise of civilized Law. We need to modernize our collective thinking patterns to account for everyone on the planet ... their contribution and share in the rewards.
As a biotechnologist I think that while the patent mentality is unfortunately still prevalent, lots of us are moving towards an open collective mindset; from community bio-hack spaces, to open access journals and open source projects. The biotech community is becoming less corporate.
Vaughn Utube ah man, it does suck. But if X person puts in X amount of work, they should be rewarded. I do think the whole system needs an overhaul. I am not certain if genes that exist in nature or found later to exist should be patentable. Should the patent last so long? I don't have the answers, just the questions :)
Oh yeah I agree, if person X puts in the time they should be compensated for it. The problem is when he makes too much. Let say 1 billion for instance. They probably deserve it? ... but then every year after that, he'll make $300 million more or less just on interest alone. And so for generations ( or till the next war ) we'll be enslaved by these individuals just generating and protecting their growing wealth (and diminishing precious time we could have used discovering something else for the benefit of man/woman kind) ... it's stupid and we all need to put an end to it.
Patents are necessary; without them, incentive for innovation will be lower (Not gone, obviously, but do not underestimate the power of financial incentive). What is not necessary is for patents to become the brand protector for immortal companies, which is what they are now thanks to companies like Disney.
Stop with your playing god bullshit. Its fucking science. Go live In the forest and avoid all 'gods' inventions. Or better yet go to mid east where ppl pray all day.
about the Wooly mammoth: currently the climatic conditions might not be good for that. if the new ice age will appear, the chances might be higher ;P
eugenics is a weapon. always has been always will be
Everything can be a weapon
5:25 So your saying its relatively cheap. Like SpaceX falcon 9 vs Atlas V cheap?
She dropped some real knowledge there at the end. =]
disarmyouwith a
hmmm is there any posibility to bring back lost hair or not to loss hair mostly in men.🤔
"Adaptation Is a sigh of Intelligence"... Well, this relationship is more close that I thought.
What is the success rate?
4:29 haha we've been doing that forever..
yes gene-editing is exciting. when the strand is broken or torn apart, as such, much like tearing an arm from your body, no matter how many surgeries you get, you cant "get back" to the "original form". this "tearing" event will always a probably in this process.
Not true in 2002 I was studying how they can regrow your arm or whatever you want as long as you have the DNA from the baby being born you could pay 3000 grand a month and cryogenic the belly button cord blood they pulled me out the room told me to never speak of it again or my son wouldn't be able to be born there. I gave other family's the info and they did it most rich. Js
Man can this fix my hair? or more precisely the absence of hair on my head? i kinda went half bald at 17 (completely bald now) and goddamn did it hurt.
like to know the basics of crispr i m new to this in lay man term
Well this made me less confident in the astraz vac. ...
Where this treatment is available in India
I suspect that Crispr will become so cheap that is can be done on a kitchen table. It just needs one person who believes it is possible. And that person will be backed by the entire human population, and they will make it free and accessible for all and everyone. This is inevitable.
Cas 9 is skin editing system?
"How can we justify wiping out an entire species that we consider harmful to humans, off the face of the Earth?"
You just answered your own question; the species is harmful.
parasites also play a large role within the web of life.. and the food chain, basic science man.. no matter how small it can have a large effect.. chaos theory, butterfly effect, things like that..
at the end of the day its a prey, predator and parasite relationship.. u cant eradicate a whole specie of tigers just coz they are wild and dangerous and can kill humans and other animals.. and that can mean eradicating the whole feline specie..
and humans also harm and threatens other species, we r the only specie that kills for fun.. not for survival
Don’t want to sound edgy butttttt “I am become death, destroyer of worlds” Now........ die despasquitos 😂
Well, that would disturb the environmental cycle or the food chain resulting in some severe consequences...
humans are harmful to so many species and I don't see anyone inventing tech that can wipe us off the face of Earth
@@mitalilal6215 wow?? You must not love yourself. Sad
You don't need a professional lab, you just need the equipment and necessary skill
How much would it cost to set up my own lab?
All I've got to say is Einstein was right. We need to establish common ownership and democratic control of the collective product of our labour. CRISPR is a product of human labour. Turning it into a privately owned/sold commodity will turn its few owners into the rulers of the immense majority, the producers of the wealth of nations.
I saw that in a movie... the end was not good 😂😂😂
while the good people who understand genetics are here I have a question , I hear about modifying genes as a future possibility how can you modify every DNA in every cell in the body of life organism . I understand how it can be done to embryos but how can it even be possible for a living organism ?? thanks
last shadow By using viruses that infect your organism, as she said it's not easy.
Because of cell division the modification spreads. Not a good technique for cells which don't multiple as much, like brain cell, muscles, etc But for those cases, we have just found a way to edit RNA using CRISPR and cas13.
same way, just more cells the virus has to enter, especially the targeted area needing treatment, liver, spine etc... i would imagine. Or even change the edit of our base stem cells so that production will be reflective of the new edited cell. But again im just spitballing.
Now thats crisper for ya
Will this work with genetic mutation that are hereditary and then inhibits certain enzymes to be produced in the body??
Yall I need some gene editing on myself!
@6:29 “The devil is in the details.” Very interesting choice of words.
There are two types of tomatoes. Naturally grown and GMO (genetically modified organism) aka DNA 🧬 edited.
The naturally grown tomato is a product of nature and is not owned by a corporate patent.
However, GMO tomato is owned by a corporate patent. Think Monsanto.
So the question is, if your DNA is edited by CRISPR technology, who will own you?
C19 has allowed 90% of people to be MRNA edited
The quote is just an English proverb used to remind someone to pay attention to the details, used in a lot of poetry and literature.
Regarding the ownership bit, the genetically engineered tomatoes have a patent because they’re commercially sold products, so ofc a company is going to put a patent on tomatoes that were genetically engineered to be better than others, thus potentially outselling any other tomato options available.
If humans were to have diseases treated with CRISPR, then it would be a patent on the certain innovations regarding the technology itself (to prevent other competitive pharma companies from being able to use innovative mechanisms themselves), and not anyone who’s gotten those treatments.
By the same thought thought process, people who have had certain vaccines would be owned by an entity due to certain vaccines, or parts of them being patented.
@@anthonydo9945 Have you researched what’s in these CV-19 vaccines?
There are CRISPR kits you can buy online and do at home ;)
Patent a technology when there are so many unknown consequences ? Seriously 😶
I think that the hall life is compatible and in harmony, you need to change the hall universe genome in order to balance rest and comfort, yes there is a corruption. so, I think that your researches should forwarded to or directed to returning genes to their original way of action, like cleaning people from the corruptions that have evolved through time of being.. here you need to find the first gene and dna. and copy it then edit genome according to it
5:25 Finally fixed her hair during the clip.
Can we reverse aging?
awesome!
@@danishajaib1923 yes but it's hard and will take alotta time
No we cannot. Not significantly but crispr scientist are working on this. Look up David Sinclair he's a geneologist for that study.
gimme imortality.
In my opinion those who desire immortality.. are the very people who should not have it..
Claudeus Gothicus being immortal would be kinda boring eventually.. and it would only be cool if everyone around you was immortal.. and with how the human brain is I don't know how many humans will take pain from trauma that happens over and over again for eternity