It is obvious that this is correct theory otherwise cloning would not work, and it was Robin Holliday that first suggested this theory in 1980s. Also why some cells may not reprogramme in some experiments is something we need to know but should not be guessing to much on.
Have iPS cells been created from senescent cells? For that matter, have they been produced from a differentiated cell of an old senescent animal? If anybody knows the answer, would you please cite the literature. Thanks.
To @: surfreadjumpsleep what you said is interesting. There is something called cell competition. This is where a cell that’s metabolically superior will overtime come to dominate a tissue. Could youre “ex Vivo created cell” be able to overtime rejuvenate a tissue. I wonder!
Even when there is a loss of information past the point of no return, couldn't we ex vivo create a perfect DNA, epigenome cell? Then grow and repopulate. Of course easier said than done.. namely how to replace crucial cell types like neurons, immune, arterial and heart.
Another great conversation, thanks!
It is obvious that this is correct theory otherwise cloning would not work, and it was Robin Holliday that first suggested this theory in 1980s.
Also why some cells may not reprogramme in some experiments is something we need to know but should not be guessing to much on.
Have iPS cells been created from senescent cells? For that matter, have they been produced from a differentiated cell of an old senescent animal? If anybody knows the answer, would you please cite the literature. Thanks.
To @: surfreadjumpsleep what you said is interesting. There is something called cell competition. This is where a cell that’s metabolically superior will overtime come to dominate a tissue. Could youre “ex Vivo created cell” be able to overtime rejuvenate a tissue. I wonder!
Even when there is a loss of information past the point of no return, couldn't we ex vivo create a perfect DNA, epigenome cell? Then grow and repopulate. Of course easier said than done.. namely how to replace crucial cell types like neurons, immune, arterial and heart.