FIRST PASS METABOLISM | BIO-AVAILABILITY | HEPATIC EXTRACTION RATIO
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- Опубликовано: 24 авг 2024
- This lecture is useful for understanding the concept of Bioavailability & Extraction ratio with the help of numerical based approach.
It also includes a clear explanation that how first pass metabolism affects the bioavailability.
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Disclaimer:- This video is for knowledge purpose only. I am not promoting self-medication. I am just making ease the medicine's knowledge. I don't sell or provide any medicine, So don't take medicine by yourself and consult your doctor before taking any medicine. Thank you very much! Wish you all the best!!
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Mam your only one which is. World best cology teacher
Aap jaise mam ko Koti koti naman 🙏🙏🙏🙏🙏🙏
Same to same mere principal sir ki tarah explain karti h aap.
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Providing well concepts salute u mam...
Absolutely amazing ❤❤
Best explanation 🎉
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such a understable video thanks a lot maam
Must say...Ur Teaching skill soo outstanding 😍
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Thanku so much have given a excellent explaination mam😊
Outstanding teaching mam
Very knowledgeable video thank you mam.
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Thank you ma'am I'm totally understand this topic
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nice explain mam
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Mam plzz replied me how first pass metabolism occurs in lungs and intestine how is this possible?? .... mam plzz replied me ...
Mam jaise clg band h to aap kuch important topic padha digea diploma k
Thanks mem 👍👍👍
Thnq ma'am .
Very informative lecture ma'am..
Easy to understand
Thank you so much❤️
Mam,as we read in pharmacokinetics that firstly the drug will be absorbed,then distributed,then metabolism,then excretion..but in first pass metabolism this process is not followed as metabolism in liver happened before distribution.So i have confusion regarding this concept.
First pass metabolism & metabolism both are different phenomenon.There is no such sequence, metabolism and excretion occur simultaneously with distribution.
First pass metabolism is known as presystemic metabolism whereby the concentration of a drug, specifically when administered orally, is greatly reduced before it reaches the systemic circulation.
Whereas Metabolism is a term that is used to describe all chemical reactions involved in maintaining the living state of the cells and the organism by which your body converts what you eat and drink into energy.
@@HEMASELIYA thankyou😄
Same mera bhi doubt tha
Thanks mam🙏
Thanks a lot!
I'm wondering if first pass is part of phase 1 or do first pass and phase 1 happen at the same time for prodrugs?
Thanks a lot
Phase 1and Phase 2 reaction are the reactions involved in drug metabolism whether it is first pass metabolism that takes place in liver and gut or metabolism at any site of the body i.e. lungs, kidney, G.I.T etc
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Thank you ma’am
Bioavailability is the. How much drug effect on body for how long so ….how portal vein come in bioavailability?????
Appreciable.....#distributing_knowledge amongst all 👍🙏
Thank you !!
Thanks Mame 😍
Mam why not that drug get absorbed in arterial blood ?? Stomach amd intestine main to artery hota hey na jo oxygenated blood supply kartey hey ...uss artery ki blood main kyu absorb nahi hota...kyu drug ko portal vein main hi jana hey .?? Love from Nepal💗
Beautiful
mam iv route se bhi drug liver ke dawara blood me phochtee h ya darect blood me phoch kar effect detee h
IV route se direct blood mein drug phuchti h aur effect produce krti h.
@@HEMASELIYA Thank you mam
@Dr. Sadaf prodrug activation ke 3 mechanism available hai-
1) By Cytochrome P 450 enzyme-
occur in liver
2) Enzyme mediated hydrolysis
3)Chemical nonenzymatic
processes
Enzymatic and chemical mediated activation occur in blood and tissues. So prodrug can be given by oral as well as parenteral route.
I hope you got your answer.
Notes chahiye mam plzz mam
Magar mam drug 💊 ka pharmacological action (Except prodrug) before metabolism hota hai na
Aur FPM metabolism diff terms hai kya ??
The goal of Metabolism is to make the drug easier to excrete.
Process involve in First pass metabolism is same as metabolism but the only difference is in case of FPM after oral administration, drug first goes to liver through portal circulation , undergoes metabolism & then enters into systemic circulation.
In case of metabolism drug directly enters into blood, produces its pharmacological action and undergoes metabolism in the liver and other tissues.
Fast dissolving film mai first pass metabolism kaise avoid hota hai
Aur uski effect kaise reduce hoti hai
Mam only orally possible hai ???.. ay any other route me hai ?..
Will the drug not get absorbed in large intestine and enter into systemic circulation? In that case bioavailability of drug will further increase
Highly lipophillic drugs can absorb from the large intestine into inferior mesentric vein which further connects to the portal vein.
So drug absorb via large intestine will also undergo first pass metabolism.
@@HEMASELIYA thank you so much ma'am
Pharmacological action dikhane ke bad drug ka kya hota hy maam??
Drug receptor binding k bad drug & receptor dono mein conformational changes aate h or pharmacological effect produce hota h.
Iske bad drug receptor se dissociate ho jati h (depending on the dissociation constant) or body se excrete ho jati h.
mera liver bs 10% drugs hi aage bhejta hai mam kya bimari hai.muke
muje
It depends on the drug as well as metabolic capacity of individual.
If it happens with only few medications than the cause can be genetics like some individuals are fast acetylators , in this case drug which undergoes the acetylation will enter in the blood circulation in a very less quantity.
If it happens with every drug than it is due to overactive liver. High levels of liver enzymes and other chemicals in the blood might mean that you have hepatitis, liver disease or cirrhosis.
kindly enzymes ky name tu bta dain jo inhein disintegrate karygi??
Cytochrome P450 and UGT (UDP-glucuronosyltransferase) are the major enzymes involve in first pass metabolism.
@@HEMASELIYA kis book ko follow karian ? Katzung K.D triphati or Lippincott
@@naveedakram2295 if you want to get updated information then I would suggest not rely on books only, you can check research articles also.
As far as the book concern for pathology Rang and Dales pharmacology and for mechanism of action and classification KDT is good option.
@@HEMASELIYA i want to be the best in pharmacology
Writting tora sa shaf karna mam
40% kaise bach rha h drug last mei?
Can you translate in english
Yes, but it will take sometime.
60% metabolism ho rha h 70% of orginal amount
You have to consider absorbed drug which is 70 % as 100% while you are looking for metabolism.and in the discussed example out of this 100% 60% gets metabolized and remaining 40% will be available for pharmacological actions.
Toh bach kaise rha h 40%?
Thanks mam
Thanks mam