Cleo Abram: Metformin, the Anti-Aging Drug… or is it?
HTML-код
- Опубликовано: 29 сен 2024
- JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders [Standard Tier]: bit.ly/Physion...
Join the Physionic Insiders [Pro Tier]: bit.ly/Physion...
Standard Tier: Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More
Pro Tier: All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More
HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: bit.ly/healtha...
JOIN THE COMMUNITY
Join my Community [It’s Free!]: bit.ly/Physion...
EMAIL LIST
One Weekly Email of Value: bit.ly/2AXIzK6
HIRE ME FOR CONSULTING:
Consulting: bit.ly/3dmUl2H
DONATIONS FOR A SCIENCE BASED CAUSE
Patreon: bit.ly/Physion...
OTHER SOCIAL MEDIA
Instagram: bit.ly/2OBFe7i
Created with Biorender
References [Copy and Paste DOI into Search]
[1] doi: 10.1111/dom.12354
[2] doi: 10.1093/ije/dyac200
Cleo's Video: • Metformin, the Big New...
*******CRITIQUES, RULES, AND NOTES*******
Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and RUclips is less likely to promote it (these videos cost me a lot of money to produce).
Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:
Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of RUclips comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, RUclips auto-deletes links, so I do not see most comments with links attached.
RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.
If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).
Please use the following link to submit your critique: bit.ly/Physion...
Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.
#metformin #antiaging #hugeiftrue
![Why your Low Carb Diet is hurting your Heart, and How to Improve it. [11 Studies]](http://i.ytimg.com/vi/tla-JrqhhHI/mqdefault.jpg)
![Why your Low Carb Diet is hurting your Heart, and How to Improve it. [11 Studies]](/img/tr.png)
That smudge on your wall is starting to drive me nuts because everytime I watch your videos, I think it's on my screen and can't get it off😂
Oh my goodness! Me too!!!!!!!! 😂 I feel normal now.
Yeah, the background is depressing
It's a water sprinkler
Metformin is obsolete now when we have GLP-1 options like Retatritude etc
Studies presented as science are really not science at all. They just pose a question and whether it merits further investigation as to the actual underlying biologic function. Don't base your living choices on 'conclusions' from studies unless you want to be a statistic.
Did you... supersize your arm in Photoshop for the thumbnail?
No
@@Physionic HUGE if true then, damn. =)
Good one! Thanks!
how can a medicine that messes with mitochondrial compound 1 reducing ATP production be longevity positive?
One word for you ... Hormesis ... Google it ;)
I don't know. Maybe we should all wait for the research before jumping to conclusions based on hypotheticals?
By reducing Reactive Oxygen Species (ROS) primarily producing in complex 1 and 3 in ETC.
I think its because it upregulates AMPK. It's also known to negate the benefits of exercise so I would consider it a net loss. This is all part of the David Sinclair hype train in which everyone lapped of his garbage like mothers milk and he got rich. The next air to the throne is Bryan Johnson. More sales with no robust outcomes.
I went low carb lifestyle. Taking metformin (Dr prescribed) I had hypoglycemic attacks twice a week. I stopped the stuff, still have 3 full bottles.
Problem is it has negative effects on exercise and muscle building ive heared
Studies have shown it inhibits anabolism(muscle building) by about 10%. That’s the reason Peter Attia quit taking it at one point. I don’t know if he’s still off of it or not. Unless you’re doing body building, when you’re younger 10% probably won’t matter much. But as you get older, especially past 65, it becomes more important because it gets so much harder to build muscle.
@@johndoe-gt6gp interesting thnx
I have read it lowers testosterone. So its a No for me.
I took it for awhile however decided to get off of it /p(my choice for both). I didn’t find it made much difference. Also, I’ve heard that it can deplete B12 so I did make sure to supplement B12 and/or B-Complex.
@@wintersprite yes, it does deplete b12.
Metformin lessens the risk of glucose inflammation but does not address or treat the main cause which is addiction to highly processed foods and thus the dietary overconsumption of glucose/fructose the consequences of being chronic tissue damage associated with aging. There are other factors into aging, but a highly processed food diet is a major cause of aging. The natural and more direct way to lessen the damage caused by high glucose blood levels is a more active lifestyle, better sleep habits, PLUS a low carb/starch, lo-Omega6 fat, hi-Omega3 fat, hi fiber diet which in turn would reduce aging and extend the lifespan without medications or expensive surgery. However, most medical doctors are not trained in nutritional/dietary science or in physical therapy or how to handle addiction with highly processed foods.
Thank you
I'm in the TRIIM-X trial and lemme tell-yah. Metformin does not make one feel awesome, even when on all the other stuff lol.
Bet it turns out to be bollocks.
Lol. A few minutes into the video all I could think was "retraction!!!!"
You said it’s not necessarily the researchers’ fault, but the simple fact of him getting so excited with the media attention, as well as all this talk of repurposing based on a study that goes against randomized control trials, shows a handful of redflags…
Man this channel is good for helping people to brush up on critical thinking and analyzing data in general. Can apply these skills to any field. Salute to da Doctor 🫡 👨⚕️
Berberine is supposed to be as good as metformin for those with type 2 diabetes. It would be nice to see the exact same studies done on it for anti-aging.
dihydroberberine showed better results than metformin with 3 patients I know
I took one tablet and didn’t have a stool for 5 days 😬
Compared with metformin, berberine exhibited an identical effect in the regulation of glucose metabolism, such as HbA1c, FBG, PBG, fasting insulin and postprandial insulin. In the regulation of lipid metabolism, berberine activity is better than metformin.
Yes, I switched from metformin (and it was free to me) to berberine and it has helped me lower my a1c and has helped me lose weight.
Maybe, but Berberine (and many other phytosupplements) is by far more expensive than metformin.
From my local pharmacy I can get 30 tablets (1000mg/tbs) metformin with less than 3 euro, this is 60 days supplementation!
@@hristosstrihas4010 You have to do what you have to do, meanwhile, Liposomal Berberine is available, minus the side effects of Metformin for the most part and will blow it away on both counts, A1C and Lipids.
Working out hard doing cardio and strength training 6 days a week makes me feel good and healthy. That is the only supplement I trust. No other snake oil for me.
Good sleep good nutrition good exercise will keep you alive and healthy longer than anything in this world lol
I took metformin to experience if it works after 2 weeks of taking metformin I quit because I wasn't feeling good, I had low energy, I was depressed and confused. short after I learn that metformin destroys the good microbiome and inhibits the absorption of vitamin b12.
I took it for nearly a year, stopped because of explosive diarrhea 😢
Metformin is done. We must move past it and continue the growing longevity research.
Metformin ruined my dad kidneys and did not control his type 2 diabetes as well as Berberine did, which as a bonus reduced his cholesterol and improved liver markers too and its prescription free
Most people wouldn’t have to be on these drugs if they just lost enough body fat and built some muscle. So sad and unnecessary.
Some people who have diabetes have higher risk for kidney issues so not sure how you’d know it was the drug or his diabetes, etc., that ‘ruined’ his kidneys, etc.
@@BlahBlahPoop617 Pretty much hit the nail on the head. Uncontrolled glucose levels (honestly, anything ever over 140) are like little knives to the periphery capillaries. This damage accumulates and is the reason we lose toes, vision, suffer ED, and do organ damage. That said... metformin is not great for kidneys, so if you already have kidney issues, you need to come off metformin (nurse)
Also, I'm 8-10% body fat. Very well muscled, but if I am not insanely strict with my carbs and exercise timing, my glucose stays in the 200s. Shitty genetics are still a thing
Loosing weight is not so easy when your satisfaction center in the brain is out of balance@@BlahBlahPoop617
Berberine is 100 percent the way
There was an Interventions Testing Program (ITP) study that evaluated metformin's effects on mouse lifespan and aging. The results showed that metformin alone did not significantly extend lifespan in these mice.
There are a bunch of subsequent studies that show metformin reduces long covid, improves the microbiom, delays aging through lengthening telemeres, improves cardiovascular disease, and attenuates varios hallmarks of aging. I was pre-diabetic 5 years ago. I changed my diet, added moderate excersise and began metformin. Today , my symptoms of high bloodsugar have all disappeared, and my fasting glucose is always in the mid 80s. I still test every morning. Metformin is cheap as dirt, and safe. Even if you put aside the longevity benifits; just the fact that thru diet, excersise and metformin, my bloodsugar is optimal and i am now at my college weight. 57 years old with my college body back!, makes metformin very well worth it for me.
It's a pity that the TAME trial hasn't started yet, and in fact isn't even fully funded yet.
Could diet and moderate exercise alone have improved you the same amount?
Dr. Osborne made a video, were he points out, that it depletes B12. Folate and coQ10..And the possible consequenses.
it is interesting the similarities in the effects between berberine and metformin, despite the differences between them.
I'm the chart, Prevalence of Chronic Conditions as a Function of Age, the point of Divergence is where Diabetics Begin dying of Cancer and Heart Disease.
i would love to hear your thoughts on Berbrine...which apparently works better than Metformin. :)
The TAME trial has yet to begin due to lack of funding.
Are my headphones broken or is there a very high pitch noise throughout the video? Especially at 0:40 I can very clearly hear it
The pharmaceutical co. Would over charge for it if it works
Be careful of B12 deficiency when taking metformin.
So basically the verdict is still out if metformin is good to take for healthy individuals?
Right
@paulwolf3302 and since it doesn't get you high, it's hard to get it on the street
BTW, lots prescription drugs are safe without a Dr, but are illegal
My preferred supplements are anything that makes me superhuman.
Longevity is not a pill people. It's a skill
... can we profit off of aging? let's throw money at it
@ 06:26 "we believe". Ironic that a researcher should pick this verb phrase since it is what almost all of us also fall under in making our choices. Ask anyone what scientific proof they have and you're likely to get ramblings that amount to nothing more than hearsay. It's a sin we're all guilty of.
One problem is that people don’t necessarily carry a bibliography or list of their references in their heads even if they have read the studies. If you ask me what my evidence for X is, I’d have to get back to you on that after looking everything up (again), which is too much trouble for most folks.
Pure pablum
There are tons and tons of stuidies out there showing the many benefits of Metformin. Not sure why none of those were mentioned.
Because this is focused on longevity?
Metformin an anti-cancer drug???
Berberine is supposed to work similar to metformin and is natural.
Supposedly DiHydroBerberine is better.
metamorfin is natural too, no?
@@iaan81No, but it's supposed to be more bioavailable than berberine. (Might depend on the form of berberine.)
To think....if there was something simple that everyone could do to add health span, for sure, to their life, and almost certainly lifespan.
diet......exercise...other lifestyle choices....anyone....anyone.
I thought Metformin was originally used as an anti-seizure drug, THEN as a diabetic drug. But maybe I’m mistaken
Is berberine actually that similar to it?
Is it Berberin for carnivores?
Inositol does the same thing
Doesn't berberine have similar benefit with fewer side effects than metformin?
That's what I take. Has helped me lose 5 lbs. and reduces carb/sugar cravings too.
Watched an KOL using it for anti aging but he shrivelled like a prune with lots of wrinkles in a couple of years. Frankly he is approaching 60 something but he was a good looking middle aged man. Now he looks fragile and wrinkled
Will done, I was not so luck, always when doctors prescribe one drug you need another to protect from a side of first, am sure that how drug companies made drugs (one drug and by the way you will need other one as will ) also PPI's drug to protect your stomach, from drugs that can damage the lining of your like same blood thinning drugs, also stops you stomach for absorption of B12 🙏🙏🙏🤔
Then, there is Invokana association, which indirectly supports Metformin case...
Do you believe studies?
Would this not mean that metformin would get a new patent for some kind of "anti ageing" BS which would drive its price up as a tyoe 2 diabetes drug?
I know this turns off many people (pandemic fatigue). Interesting study: Metformin reducing chances of long covid. That can be interesting considering many are experiencing multiple unmitigated reinfections with Covid these days
OK, I'm gonna be "that guy". There is no magic pill. You need to make better lifestyle choices. And you need to put in the work. Get to it.
i bet you thought you said something deep
No, I said something that should be basic common sense.
I’m not clear on how metformin is expected to “push back death by age-related diseases” other than type 2 diabetes? Do they already understand its mechanistic contribution to longer life-span in that very specific population?
Nick is enamored with Cleo, I can see it in his eyes. Can't blame him though, she's both Cute and Intelligent. Intelligence is very Sexy.
People have been claiming that for a long while. It doesn't work.
The way she says things, sounds like that discovery will change humankind. Dude get her on the show somehow, date her or something
I can see why the interesting Metformin. Nic the other study you mention on longevity used several drugs to reduce a fatty thymus I think and it used Metformin. When 80% of the risk factors for cardiovascular dies ease and stroke are metabolic including diabetes.It makes sense that if you reduce those risks you will live longer. Metabolic disease and diabetes is sky rocketing most likely due to the food we eat and lack of exercise. This mostly a lifestyle exacerbated by genetics problem., with environmental concerns added.
Metformin ☠️
Berberine entered the chat...
3:20 the two lines converge at the end, the slope seems the same so maybe some few random deaths in the non-diabetic people but it evened out , so just blowing out of proportion a non result
Damn
One group of researchers has been looking at it for yrs as part of a cure or prevention for aging and or life extension. Watched a good doc video on it a few yrs ago and read some articles.
If the MSM was promoting it? I would leave it to the mainstream.😮
Cleo reminds me of Brook Shields
@paulwolf3302 "medical credentials" doesn't always indicate good advice. Thats what i like about Physionic, Nicholas always lets the audience be empowered buy allowing the individual to make their own conclusions by judging his simplified version of the complex info he presents
Or Natalie Portman?
Why your eyes are red on the video? 😅 Sorry for the question 😅
I have seen patients taking dihydroberberine, 100mg after dropping 500mg of metformin, and their results where better. Also, reports shows metformin could cause peripheral neuropathy which from there causes diabetic foot ulcers
This comment is all sorts of backwards and wrong.
If it proves to be an anti-aging drug, you can bet it won't be "cheap and available to everyone" anymore, lol.
Metformin definitely worked not well for my dad's diabetes and kidneys . Berberine worked much better and didn't affect his kidneys. Most doctors know Metformin affects on kidneys hence why l kidney disease people avoid it
It will still be. It’s common domain, so unless the companies change the molecular structure, it will still be very cheap. Even if they do, the current version will still be very cheap.
@Physionic I assume the ability for any lab to manufacture the drug will keep the price down? I suppose so long there's no collusion between companies (which I am aware is illegal) that would hold true.
@@Physionic
What is the definition of "very cheap"?
How does it compare to a bottle of generic aspirin?
@@mballer Metformin is also sold as generic
Just Say No to Drugs.
Metformin very noticeably but reversibly reduced my libido. Anyone know the mechanism? (I am metabolically very healthy, HOMA-IR around 0.5.)
It reduces testosterone. It had devastating effects on my ability to walk and I am female over 60. Imagine what it would do to men's testosterone? I have zero confidence in our so-called medical system and even more skeptical about research professors.
Nick we look to you to restore our faith that there exist honourable scientists who are not easily bought to be shills for big pharma.
I would say, MET down regulates MTOR via upregulation of AMPK.
This move the body into a catabolic state. Such state would naturally be found in a long-term fasting food-deprived situation. I observed the same during a weight loss period. Sex and proliferation is not the priority if there is no food.
But why on earth would you take MET with a HOMO-IR of 0.5?
I was on met for for quite a few years. It causes neuropathy. This is one of the big problems with it. I had the flu like symptoms from it. My doctor told me to push through it and yes, after while I was on met Forman and 70-30. What a shit show made you hungry all the time gained so much weight got so unhealthy then they put me on blood pressure medicine. The fatigue was huge. I walked out last year started getting better. It’s over a year later now no more strokes June was the last month Doing so much better with nothing I didn’t mention the statin, but that gave me swollen legs two weeks after quitting the statin my right leg had gotten pretty normal not so swollen. The other one took about nine months. I don’t believe what Doctor say anymore that’s why I listen to you, trying to find the magic pill that will make me better at some point I won’t need anything yet. Berberine was a big thing for me. It helped so much now I take probably a dozen supplements and doing better getting my energy back slowly very slowly, my doctor keeps wanting to put me on a blood pressure pill, the funny part is they don’t even know what causes your blood pressure to be high yet they wanna put you on. I read about everything would not take a blood pressure pill there’s natural ways to control it yet. It’s still high. The nitric oxide is huge from what I read I eat beats every dayyet still have high blood pressure keep looking for things for that one have the best day ever and keep up the great work Nicolas I watch everything you do you help me very much
I had a stroke as well and I've tried every supplement known to man, yet can't get off blood pressure pills. I'm fit, lift 4 times per week, walk to gym and grocery store and it still rises when I get off the pills.
It seems like you can avoid neuropathy by supplementing B12. Diabetes also causes neuropathy.
It causes neuropathy because it depletes b1 and b,so in general
@@hippopotamusanonymous1580 Just gotta supplement
Met, not even once.
On a side-note, I would love to see a co-lab with you and Chleo tackling methodology and statistics. I think it could reach a lot of people who need an eyeopener.
Hey this babe is the perfect girlfriend for Nick.
We are born 100 years too early, maybe.
Give it 20 years, AI longevity medicine will be ubiquitous
Perhaps the longevity crew should take a look at the research on an even cheaper drug that can't be patented: lithium and its alleged anti dementia affects. Been a while since I've heard anything about that one
And also other mental health benefits. Apparently in regions where the water has more lithium, there are fewer mental health disorders. Even microdoses could help in the medium term, so you could track down the highest concentration water you can regurlarly obtain and drink that daily. If anyone from Portugal is curious, found a study of portuguese waters that analised lithum concentrations and Vidago and Pedras Salgadas had the highest. Vidago has less sodium, so thats what I buy. Just 250ml per day is comparable to a microdose of lithium for some mental health disorders.
@@pedro.almeida Japan was the place I remember having higher concentrations of lithium in the water.
@@anniealexander9911Muh Lithium
Muh Metformin
Muh NAC
lol youtube longevity is a joke
I LOVE your videos! I’m wondering if you’ve ever thought about doing a video on over feeding studies where the subjects do not gain an appreciable amount of weight? And how that comports with the obesity epidemic.
Are prices going to spike?
I've spoken to many centennials. I live in the Caribbean isles of Trinidad and Tobago. Some smoked for decades, they drank soft drinks, ate fry foods, barely took supplements. And they all lived in lightly forested areas. And the secret to their long lives was so simple. All of them were not obese also. People of African/Indian/Mixed decent.
They ate once or twce a day. Small portions. Rice, meats, vegetables. Did some kind of work around the home/yard. Rested during the day in intervals. Made sure to rest early, no meals prior for an hour least. Ate fruits also. Normal small amounts. No candies. Chocolates yeah. Drank tea, bush tea, coffee. All of them also was exposed to sunlight doing little gardening or stuff in the yard/land. When it's extremely hot, they all kept inside. So mostly early morning and evening exposure, when it's cooler, as it's the tropical region.
So my conclusion, the key to long life is what you consume, how much, giving the body time to repair/recover, no strain on the digestive system. One thing, they all ate around 6pm. went to bed 7 to 9. No supplementation, if any, an occasional vitamin if they got from a family member. So through foods, they had to be getting essential nutrients.
I guess your digestive system, not putting to much stress on it, and little exercise.
The elders that lived to their 60s to 80s, they all either smoked heavily, were diabetic, and were not eating as the centennial fully. One had heart problems from birth.
Many individuals on drugs, I've known or do know, eventually developed new syptoms or conditions down the years, sickness never healed and rid of, but masked.
From my own experiences when I was in my 20s to mid 30s, I was muscular, slim, BMI on spot, bodyfat was within 15 to 20 percent. I never used to get sick, even amongst sickly people. Can be in rain and full sunlight, in the bush amongst dirt, creatures. Used to eat twice to three times a day. Small portions. Breakfast was very light. No oily foods, margerine, soft drinks, alcohol, smoking. Vegetables, fruits, meats, rice. Always active, lifting weights, doing martial arts. AND no stress from woman, till recently. Stress is another factor towards aging. Sometimes it ain't woth the expence of your longevity and happiness.
I've slacked off alot. Getting back on track. Can't cheat or skip your progress. It will be harder to go bak on the rails from derailment. Hopefully this comment, can help people. I'm no expert. Just sharing some things off my experiences and self analytics thereof.
They all drink sorrel tea (hibiscus).
@@1980sDude yes, amongst other bush. Fever grass, soursoup, guava, paw paw leaves, a type of grass I don't know the name of, and many others along with tumeric root, like what rasta use in Jamaica.
The life expectancy of someone in Trinidad and Tobago is 74.87 years, which puts it at 96th. This is far below even the US, which is pretty bad for an OECD country. Just saying.
Metformin has a recall in 2022 for containing NDMA a carconogenic ...not good for the stomach also ...the toll on the digestive
system can be quite bad for some people ...dont think i will be taking any ...i,m on Berberine now and its ok .
That recall was about one production facility for a short time.
Agreed Metformin wrecks my stomach even after a month of 250mg ( a low dose) stopped taking it.
I'm also very sensitive to Wegovy as well insane acid reflux.
Life extension is somewhat of an obsession to many. I really don't get it.
I would much prefer studying what kind of death is most pleasant and smooth, and how to get one of those.
Well that's just you, some of us have loved ones that we want to spend more quality time with, life extension means health span extension
edgy
You can have any preference you want but I don't believe you or anyone else is too stupid to understand why someone would want to live longer.
Just say you're depressed and leave the nonsense out of it. You're more likely to get the response you want if you're honest.
@@ericmaclaurin8525
Long life is a chance. Death is a given.
Why wouldn't we study how to die well?
Has nothing to do with depression.
@@ZappyOh edgy boi
if you want to live long...prepare your finances.
who in hell is gonna pay for you being around at over 90?
if you think your medicare or SS is your big plan...or even your union benefits...better stop watching these videos and start investing somewhere.
Whats the poijt being alive at 90
Life ends at 50.
Metformin does nothing that eliminating Plants and Carbs from your Diet can't do. One word: Carnivore!
Eating plants extends a person's life.