For some reason most desert levels kill the bit rate of my videos, sorry about that.
Using headsman's bloodthirster (2nd best weapon after Luci's day imo), gabriel's dauntless vision and drunkard lv. 3, you can keep yourself at ~50% damage reduction, turning you into an unstoppable tank. With potions and ALL of your buffs, that damage reduction goes up to ~63%! Bosses won't be killing you through that anytime soon :)