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O'Kon Parks

I couldn't follow you online as the time of the presentation is late night here in Australia.

Thank you Drug Hunter and all the guest speakers for your great help to the medicinal chemists.

very informative and i did enjoy it!

Excellent overview, providing many insights. Thank you!

great format. looking forward to more discussions

What an amazing review! Thanks Anh.

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Treat infections before the take over the human brain with damage and inflammation infection that’s toxic to any human neuron’s….. my neurologist wouldn’t so bye bye lost soul waste less useless service all to make a coin off anti epileptic drugs or many others lol thanks again for letting the issues cause me brain damage so I can have a life long chronic issue needing neurologist prescribed drugs. Nothing to say here about the non obstructive hydrocephalus deemed dementia a lot of the time LOL AGAIN WOW just ignore infection and physiology of the brain. Let it continue to have occurring damage inflammation neurodegenerative issues that could be attenuated but get ignored. Bye useless health services let me rot then. Been there done that seen neurologists up through the I iverstity network first 2014 then by 2020 my ventricles were so large I endured years of hydrocephalus I assume causing the epilepsy they said had no cause. lol again disappointing people look so highly to these places of fake therapy. I couldn’t get the autoimmune work up even though I told my neurologist steroids had me seizure free for almost 2 years again nothing their stupid anti epileptics could do….. Yes I see through them now after 4 neurologists of not ruling out my ear fullness been there for 14 years now same amount of years the seizures …. Chronic infections present with non acute signs and symptoms. I suppose lvl may have mastoiditis all ignored and not ruled out as causing me infection close or in my brain nor the autoimmune…. So just know they like to diagnose and adios quick to do such without proper work ups. No specialists would make sure I had no infection. The side my ears full hurts can’t sleep on it or it feels horrible the next day, hmmm!? Makes one like me think, RETHINK each thing I’m told. Wow even though an MRI SAID IT WAS INFECTION of MASTOID bilateral, 8 years after it became full one day only one ear. Told it’s not infection not an issue not a cause but it feels different the the other side it’s the side seizures are coming from and I see through all these types of people now after 14 years of studying them and their actions through my treatment and it’s only been a pill. Only thing required was to look for brain tumour in my MRI by them….. lol not safe. That’s not the only way physically a seizure can be produced in the human brain. Neurologists also disregard autoimmune issues and any physical issues like with the spine/nervous system…. Not safe for the patient.

Thank you for the nice presentation. Does this mean that current ABeta targeting therapeutics such as donanemab could lead to increased infections in patients under treatment?

Informative presentation, thank you

Thank you so much Dennis for bringing these great people to share their knowledge.

Simply awesome.

How much AI assistance the team makes use of while writing these super exciting articles and how do you foresee AI contributing further in your journey. Thanks Gagan Kukreja

Super inspiring. Besides compiling and sharing the literature, how important is for the Drug Hunter team to share their own independent insights, expert opinion/readout on the molecule being covered. Thanks Gagan Kukreja

could you list the reference for covalent binding to the backbone amine, it's really interesting! thank you!

This was very well summarized.

Good job nice

RLAY PI3K sucks

Thank you drug for sharing your talent of clear understanding in organized way.

I would love to see more presentations on process stories

Hi Dennis. I think there may be a misunderstanding. The EPSA means "exposed PSA" not experimental PSA. Please refer to the literature ACS Med. Chem. Lett. 2014, 5, 1167−1172; ACS Med. Chem. Lett. 2022, 13, 6, 964-971. As you mentioned, the intramolecular hydrogen bond of RMC-6291 may sheild the polarity of morpholine and amide, which results in a similar EPSA with compound 5

You have to study chemistry for these kind of tasks or is it possible with pharmacy as well?

What would you have chosen, to live with herpes virus, CFS/ME (etc)forever or go for the herpes virus, CFS/ME proven medicine that has worked immensely in curing people from _Dr Madida_ /-/\-\