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- Видео 97
- Просмотров 116 372
WuXi Discovery Services
США
Добавлен 12 май 2020
Delivering our partners preclinical discoveries through world class capabilities, directed by teams with a reputation for collaboration and scientific excellence.
Integrated Solutions & Research Strategies for the Discovery of Targeted Protein Degraders
Using an event-driven pharmacology approach, targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular self-destruction mechanisms. This technology is enabling researchers to pursue targets that were previously considered undruggable and to address the resistance issue of small molecule inhibitors. Since 2016, WuXi AppTec has built a comprehensive TPD discovery service platform to investigate the full functional cycle of protein degraders - from binary/ternary complex formation to target ubiquitination and degradation.
Просмотров: 269
Видео
Paclitaxel-Induced Resistant Tumor Models
Просмотров 141Месяц назад
Despite the excellent clinical response to paclitaxel therapy, drug resistance inevitably develops in subsequent treatments. The development of targeted therapies for overcoming paclitaxel resistance represents an unmet medical need. WuXi Biology has established gastric cancer and breast cancer cell lines that are stably resistant to paclitaxel. We have also established corresponding in vivo tu...
Radionuclide Drug Conjugates
Просмотров 136Месяц назад
Radiopharmaceuticals have proven to be effective agents since they can be successfully applied for both diagnostics and therapy. Radionuclide drug conjugates (RDCs) combine a radioactive compound, a tailored-targeting molecule for specific receptors enriched on diseased cells, and a linker for stable attachment, enabling more effective radiation delivery and significantly reducing side effects ...
Recent Advances in High Throughput Experimentation and Flow Chemistry to Accelerate Drug Discovery
Просмотров 2172 месяца назад
When used in early-stage research, high throughput experimentation (HTE) and flow chemistry can shorten the turnaround time of the ‘design-synthesis-test’ cycle while increasing selectivity and conserving limited materials. In this webinar, we will showcase examples that demonstrate the power of these technologies in filling the gap between innovative design and practical execution for a divers...
Combat Drug Resistance in Cancer Therapy
Просмотров 943 месяца назад
An inevitable challenge emerges over time as tumors develop drug resistance, resulting in treatment failure. To bolster the research of innovative cancer drugs and to emulate real-world clinical scenarios of tumor resistance, WuXi Biology has developed a comprehensive platform of preclinical drug resistance models leveraging in vivo and in vitro methodologies.
Poster Presentations at IMMUNOLOGY2024
Просмотров 324 месяца назад
At IMMUNOLOGY2024™, WuXi Biology has been selected to present five noteworthy posters, showcasing our panel of preclinical models representing urticaria, nephritis, rheumatoid arthritis, gout, and atopic dermatitis.
Discovery, Characterization, and Manufacture of Peptide Radiopharmaceuticals
Просмотров 3264 месяца назад
A new wave of drugs that achieves targeted delivery of radioisotopes is rapidly gaining momentum. One area that is showing considerable promise is the incorporation of an isotope-chelating moiety into a peptide ligand for targeting cell surface receptors on cancer cells. In this webinar, we will discuss strategies for the discovery and optimization of new peptide ligands for such targets, as we...
AACR 2024 Poster Presentations
Просмотров 1755 месяцев назад
Join WuXi AppTec at AACR 2024 as our experts showcase advances in therapeutic strategies tailored toward specific oncology targets. We are proud to be presenting a wide range of posters at this year's annual meeting, highlighting our capabilities in CAR-T cell therapy, tumor models, oncolytic viruses, and drug-resistant animal models.
Why isn't My PROTAC Effective?
Просмотров 2075 месяцев назад
What if a constructed PROTAC with a confirmed high-affinity warhead doesn't work as expected? In this video, our expert from WuXi Biology shares strategies to address such an R&D scenario.
Rare Disease Therapeutics: Accelerating Development and Improving Access
Просмотров 1016 месяцев назад
Advances in the understanding of rare disease biology, coupled with innovative technology and therapeutic platforms, has led to progress in the research and development of drugs for rare diseases. In this webinar, we will discuss important trends in rare disease therapeutics and highlight ways of accelerating the drug discovery and development process.
Trends in Rare Disease Drug Development
Просмотров 636 месяцев назад
Every year, the last day of February marks rare disease day. Across the globe, over 6000 different rare diseases have been identified, impacting approximately 300 million individuals. WuXi Biology offers integrated services for rare disease drug research, from the generation and characterization of animal models to colony management and pre-clinical pharmacology research. Our platform encompass...
Advancing into 2024 with Capabilities in New Modalities and Expanded Capacity
Просмотров 687 месяцев назад
Advancing into 2024 with capabilities in new modalities and expanded capacity
Wishing You a Joyful Holiday Season and a Happy New Year!
Просмотров 1868 месяцев назад
As 2023 comes to an end, I hope you and your family had a wonderful year! On behalf of my colleagues at WuXi AppTec, we deeply appreciate your trust in us. In 2024, we look forward to continuing to support your efforts to bring innovative therapies to patients around the world, and I wish you and your family a joyful holiday season and a Happy New Year.
Novel Approaches to Targeted Protein Degradation
Просмотров 1458 месяцев назад
In the last decade, targeted protein degradation technology has become one of the most promising methods to remove specific disease-related proteins using cellular self-destruction mechanisms. As of now, over 20 targeted protein degraders have advanced into clinical development.
Biophysical and Structural Biology Methods Enable Fragment-based Ligand Discovery
Просмотров 2799 месяцев назад
Join WuXi AppTec as we discuss how powerful biophysical and structural biology tools enable the study of large numbers of fragments and are opening up new possibilities in the treatment of various diseases. Here we report the results of a conventional and a covalent Fragment Screening and show how orthogonal biophysical and structural methods enable rapid identification, characterization, and o...
Accelerating your viral gene therapies through discovery, optimization and beyond
Просмотров 2039 месяцев назад
Accelerating your viral gene therapies through discovery, optimization and beyond
Empowering small molecule drug discovery by automatic DEL screening
Просмотров 48810 месяцев назад
Empowering small molecule drug discovery by automatic DEL screening
Recent Advances in Peptide Drug Discovery
Просмотров 1,6 тыс.11 месяцев назад
Recent Advances in Peptide Drug Discovery
Screening Methods to Identify RNA-Targeting Small Molecules
Просмотров 64611 месяцев назад
Screening Methods to Identify RNA-Targeting Small Molecules
Translational Pharmacology of CNS and Metabolic Disorders for Testing New Modality Therapies
Просмотров 18211 месяцев назад
Translational Pharmacology of CNS and Metabolic Disorders for Testing New Modality Therapies
Emerging Modalities in Drug Discovery - Dr. Tao Guo
Просмотров 375Год назад
Emerging Modalities in Drug Discovery - Dr. Tao Guo
Recent Advances in Library Synthesis to Accelerate Medicinal Chemistry Research - Dr. Yan Xu
Просмотров 538Год назад
Recent Advances in Library Synthesis to Accelerate Medicinal Chemistry Research - Dr. Yan Xu
Drug Discovery as an Exploration of Chemical Spaces
Просмотров 366Год назад
Drug Discovery as an Exploration of Chemical Spaces
Discovery of RNA Targeting Small Molecules - Our Toolbox for RNA Drug Discovery
Просмотров 1,3 тыс.Год назад
Discovery of RNA Targeting Small Molecules - Our Toolbox for RNA Drug Discovery
DNA-Encoded Libraries for the Discovery of Small-Molecule Hits
Просмотров 1,6 тыс.Год назад
DNA-Encoded Libraries for the Discovery of Small-Molecule Hits
Steve Yang, Co-CEO of WuXi AppTec at Biotech Showcase 2023
Просмотров 511Год назад
Steve Yang, Co-CEO of WuXi AppTec at Biotech Showcase 2023
Introduction into Fragment Based Drug Discovery
Просмотров 3,1 тыс.Год назад
Introduction into Fragment Based Drug Discovery
DISCOVERY AND CHARACTERIZATION OF OLIGONUCLEOTIDE THERAPEUTICS
Просмотров 559Год назад
DISCOVERY AND CHARACTERIZATION OF OLIGONUCLEOTIDE THERAPEUTICS
Therapeutic Oligonucleotide Discovery & Development: Discovery Day 1
Просмотров 659Год назад
Therapeutic Oligonucleotide Discovery & Development: Discovery Day 1
Therapeutic Oligonucleotide Discovery & Development: Development Day 2
Просмотров 365Год назад
Therapeutic Oligonucleotide Discovery & Development: Development Day 2
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very fascinating, thank you for sharing!
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Thank you
How can i download this ppt..???
Thank you
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Amazing!
Good one