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A case study in the confusion of correlation versus causation

Probably black Americans and Hispanics

I can confirm that I have an LP(a) value of 109 nmol/L without a statin and LP(a) of 192 nmol/L on 40 mg Rosuvastatin. Same units!

Thank you.appreciate all the information

I am 22 years old. I am diagnosed with LDL of 329. So i have started taking high intensity statins and my ldl reduced to 170 in 15 days. So is it possible to predict that what type of FH i have? I have hearts tests done and they were normal

My doctors refused to test.

I didn't realise this was a bullshit cholesterol lie!

Is the heart foundation looking into the effect of covid vaccine? If not then it's shameful!

Excellent presentation. Very informative.

I have reversed my LPa with Magnesium Glycinate and Liposomal Vitamin C at 10 grams

Why can no one say so far why it’s bad and how it functions in the body? Saying it’s bad to people isn’t right when you don’t have the reasons why

I feel for you and your family ! My daughter was diagnosed with FH at the age of 8 years old and she is now 24 , She has been put on so many different meds and also developed pancreatitis because of one of the statins at the age of 14 and now is also on rosuvastatin and ezitimibe and just got her first injection of inclisiran we lost her farther at the age of 31 to a massive heart attack because of this disease . I know how hard it is to have to see what your child has to go through because of this disease , So my heart goes out to you and your family ! You all are in my prayers God Bless you all ❤️🙏🏻God is good !

I have high LP(a) for many years. I'm 64 and my CAC is 32. I keep low carb/sugar, intermittent fasting paleo/keto eating lifestyle. Low inflammation and healthy blood pressure is the key.

Hi!!I have high chlorestral, ldl and triglycerides should I take a stain and some calcium buildup in all 4 arteries.My doctor says I should im 62 and my brother 65 has a bad heart and diabetes in the family and chlorestral 271,hdl 46,,ldl192 anf and triglycerides 172 and cal culated non hdl 226 and chol/hdl 6.0

This is a fantastic review of the status of LP(a) therapies and why it is so important to get your LP(a) tested. Even though this video is from 2022, it is very relevant today (mid-2024)

my LPa is 486nmol/L at 66. I had given up my statin of 4 years due to knee pain. I won't take a pcsk9 inhibitor but will take an siRNA knock out if its affordable. Having trouble getting a referral approved for CAC here in VT , trying to get it done in NYS. bureaucratic issue.

As someone with High Lp(a), this was the best source of info on the topic I have seen. Thank you for a great presentation

Can it cause pulmonary embolism in lungs?

I have had high cholesterol for many years but haven't been on statins because of breastfeeding. 380 is my cholesterol. I am 42. I have familial heart disease. I am scared of statins though and I have no idea why I am afraid of them..is there nothing else I can do?

Yes, statins increase lip (a) significantly for people with genetic abnormalities, for example - family hipercholesterinemy

My daughter was diagnosed with FH at 8 years old ! Her father had it and died at 31 years old ;( She was put on pravastatin but that caused her to get pancreatitis , so then was put on Repatha and then had really bad side effects like hives , stomach pains ,muscle aches, has been on rosuvastatin and Ezetimibe for 5 years now with no side effects ,they have lowered her numbers but not enough ! Not where her Dr wants it to be ,so now she has just started her first injection of inclisiran . So with Gods Will Inclisiran will be the one for her ! 🙏🙂

Isn't there a lot of subsequent research showing the fundamental flaws of the WHI? Seems outdated to state that estrogen comes with those risk factors.

I was to be in a trial to reduce LPa (mine was in the 245 range). The followup prior to be in the trial my LPa was at 150 which was to low to be in trial. The only thing that changed was I was put on Repatha maybe 3 weeks before the followup. 150 is still high but it's been in that 240..250 range for about 10 years.

What role does ethnicity play in disease risk? Are elevated LP(a) levels as relevant for African Americans, as the Caucasian population?

I have heterozygote familial hyperlipidemia with very high lipoprotein (a). I also have severe advanced atherosclerotic cardiovascular disease. Unfortunately, I am coming into LDL-apheresis treatment rather late in my disease process. I am just beginning to start treatment with Dr. Duell. In the very little time I have gotten to know Dr. Duell, he is a very kind and very knowledgeable expert in this area of medicine. I want to give hope to others with FH whether it is homozygous or heterozygous FH. There is current treatment with LDL-apheresis, and other phase 3 clinical trials of 3 medications that maybe available within the next 1-2 years. There is hope! In the meantime, do your homework! Make sure you are seeking-out medical advice from TRUE experts in this area of medicine like Dr. Duell, and Dr. Eliot Brinton in Salt Lake City.

After rosuvastatin I have lip (a) 517. I will try PCSK9 inhib.

My lpa is 66 should I stop consuming coffee..??? Does it affect??

What if you have both high trig's and low HDL in addition to very high LDL?

There are some old studies showing that androgens (testosterone, anabolic steroid) lower lp(a) by 60-80%. People who take testosterone replacement or anabolic steroids could be benefiting from it. Has anyone studied this?

Fh 8AM was

Wrong. studies and test have shown that the death risk is higher for people under 50 correlated to people over 190!!!

Thank you Dr. very informative.

That’s me

Does a person with type 1 Von Willebrands disease have better outcomes with a very high 297 nmol/l Lpa value

When is America going to become a civilised nation and sort their health care out

Why are we still chasing LDL-C and not LDL-P or apo B

Is Doc wearing pajamas?

I read a study that said Nandrolone decanoate lowers Lipoprotein (a)

I have it -- it is over 1500 so I am doomed sadly - live life

I lowered my Lp a from 147 nmol/L to 45 nmol/L after six weeks with 2000 mg of Niacin

After six weeks of 2000 mg per day Niacin treatment my Lp a dropped from 147 nmol/l to 45. I begun another six week 1000 mg Niacin treatment.

After six weeks with 2000 mg per day my Lp a went down from 147 to 45. I’m on 1000 mg Niacin per day for 6 more weeks.

Yes its how the family cooks!!!!!!!!!!! That's how it runs in the family culture of eating

Best treatment for atherosclerosis: Vitamin C Why do only coronary arteries clog with cholesterol and not veins or small capillaries? Scurvy = No vitamin C in your diet. Symptom: Your blood vessels break and you bleed to death. Think of the sailor of the past. Scurvy of the heart = Just enough vitamin C from food. Symptom: Arteries around the heart are not strong enough to resist high blood pressure. Damage is repaired with cholesterol LP(a) to prevent worse. After years of repair, your arteries become clogged. Enough vitamin C supplement of at least 3000 mg. per day gives strong and flexible arteries. Cholesterol is not needed as a repair agent. Cholesterol in your coronary arteries is broken down and burned in your liver. Source RUclips: Cardiovascular disease and vitamin C (Dr. Rath Foundation) or Breakthrough Towards The Natural Control Of Cardiovascular Disease - Dr. Rath's 2018 Cyprus Lecture

I heard over 30mg/dl was considered high.

Underutilizing PCSK9Inhibiter - its exorbitant cost is a major gactor.

Lp(a) is a risk factor, not an absolute sentence to cardiovascular disease. My doctor says "80% of CVD is environmental." So, as the video says, don't smoke, avoid obesity and diabetes, don't eat junk food, exercise, etc. Plenty of people with high Lp(a) values (which supposedly is inherited in a co-dominant fashion) never develop CVD nor have their parents and other close relatives.

Thanks for your presentation. As far as LP(a) levels it seem that the measured levels can differ when considering either mg/dl or nmol/L, they appear not to be interchangeable although 2.5 is being used as a converting number. Any comment on that? Thanks again

Most say LP(a) doesn't change much. Mine was 94 in Feb-2021 and became 150 in Mar-2024

Dr. Kulkarni, you just said that there are NOT a lot of good ways to monitor heart disease in asymtomatic individuals. Wouldn't you agree that cardiovascular inflammatory biomarkers (hs-CRP, MPO, Lp-PLA2, Alb/Creat) and AI assisted CCTA's are very helpful in MONITORING a patient's plaque burden, plaque composition (hard vs soft plaque) and degree of coronary endothelial dysfunction/inflammation?