AOPs are scientific ‘roadmaps’ that connect the dots between an initial molecular exposure to a substance or a stressor and any eventual harm that may occur to living organisms or ecosystems.
Quantitative AOPs (qAOPs) allow scientists to use numbers and models to make predictions about how a living system will respond to different amounts of a chemical - and so predict how likely, or how severe any adverse outcomes may be.
Toxicologists, biologists, and computational modellers gathered at a workshop organised by ECETOC to discuss how to develop and integrate quantitative Adverse Outcome Pathways (AOP) into EU chemical safety assessments. The workshop focused on three questions on the huma...