The London Digital Twin Research Centre (LDTRC), based in Middlesex University London, focuses on the development of state-of-the-art technology in digital realisation of the physical world. The developments in this centre focus on the digital transformation of physical environments, whether it is industry, infrastructure, healthcare or transportation using concepts and technologies from the notion of a “digital twin”. The current work in the DTRC focuses on three core aspects: Industry 4.0 (I4.0), Structure Health Monitoring (SHM) and Enterprise management.