Cellecta
Cellecta
  • Видео 39
  • Просмотров 15 383

Видео

TCR & BCR Repertoire Analysis, AAI 2024 Presentation by Alex Chenchik, PhD, from Cellecta, Inc
Просмотров 672 месяца назад
TCR & BCR Repertoire Analysis and Other Approaches for the Discovery of Drug Targets, Resistance Mechanisms and Biomarkers Presenter: Alex Chenchik PhD, Cellecta President & CSO
Dissecting the role of T-cell receptors in T-cell large granular lymphocytic leukemias
Просмотров 1955 месяцев назад
Presented by Utpal Davé, MD, Associate Professor of Medicine, Associate Professor of Microbiology and Immunology, Indiana University School of Medicine The etiology of T-LGL (T-cell large granular lymphocytic leukemias) and its accompanying autoimmune disease manifestations are mostly unknown. With the help of Cellecta’s sequencing technologies, we investigated the most abundant TCR clonotypes ...
TCR & BCR Repertoire Analysis for the Discovery of Drug Targets, Resistance Mechanisms & Biomarkers
Просмотров 1185 месяцев назад
Presented by Alex Chenchik, PhD, Cellecta President & CSO at AACR 2024 T-cell receptor (TCR) and B-cell receptor (BCR) repertoire profiling holds great potential for understanding disease mechanisms. We introduce a novel technology for profiling of all human TCR and BCR variable regions together with phenotypic characterization of immune cells in bulk in PBMCs and immune cell fractions. Prelimi...
Cellecta Overview
Просмотров 479 месяцев назад
An overview of Cellecta technologies given by Paul Diehl, Ph.D., COO, Cellecta, Inc.
Improved Adaptive Immune Receptor Repertoire Profiling for Biomarker Discovery
Просмотров 259Год назад
Presented by Alex Chenchik, Ph.D., President, Cellecta We will introduce a number of Cellecta technologies along with relevant data for drug & biomarker discovery and validation, including CRISPR functional screening, cell tracking tools, as well as the recently launched DriverMap™ Adaptive Immune Receptor (AIR) Profiling Assay that enables the identification of more clonotypes and their activa...
TCR and BCR Repertoire Analysis Exhibitor Workshop from Immunology2023
Просмотров 617Год назад
Presented by Paul Diehl, Ph.D., Chief Operating Officer, Cellecta We will introduce a number of Cellecta technologies along with relevant data for drug & biomarker discovery and validation, including CRISPR functional screening, cell tracking tools, as well as the recently launched DriverMap™ Adaptive Immune Receptor (AIR) Profiling Assay that enables the identification of more clonotypes and t...
An integrated approach to identify regulatory mechanisms in breast cancer development & progression
Просмотров 212Год назад
Presented by: Gus Frangou, PhD, Assistant Professor of Oncology and a Member of the Department of Molecular and Cellular Biology at Roswell Park Comprehensive Cancer Center, Buffalo, NY. Large-scale cancer genome sequencing studies have generated an extensive catalog of genes altered in breast cancer (BRCA). While it is generally accepted that highly recurrent somatic alterations signify change...
Adaptive Immune Receptor Profiling for Biomarker Discovery - Alex Chechik
Просмотров 113Год назад
T-cell receptor (TCR) and B-cell receptor (BCR) repertoire profiling holds great potential for understanding disease mechanisms. We introduce a novel technology for profiling of all human TCR and BCR variable regions together with phenotypic characterization of immune cells in bulk in PBMCs and immune cell fractions. Preliminary data shows that TCR/BCR clonotype analysis combined with targeted ...
Immunophenotyping of T- and B-Cell Receptors - Alex Chenchik
Просмотров 80Год назад
Immunophenotyping of T- and B-Cell Receptors - Alex Chenchik
Cellecta Single Cell CRISPR screening; by Paul Diehl, PhD, Cellecta, Inc
Просмотров 932 года назад
Cellecta Single Cell CRISPR screening; by Paul Diehl, PhD, Cellecta, Inc
A functional map of LncRNAs involved in adaptation pathways of breast cancer cells; by Matteo Marzi
Просмотров 5012 года назад
Key points: We identified lncRNAs associated with breast cancer transcriptional plasticity We will share a design of an effective CROP-seq sgRNA library for targeting lncRNAs by CRISPRi We will present a functional map of lncRNA loci involved in cancer plasticity leveraging multiple competitive sgRNA screens
Perturb-seq analysis of TNFalpha-induced transcriptional response; by Donato Tedesco, PhD
Просмотров 4492 года назад
Key points: We identified genes involved in TNFalpha-induced transcriptional response using two methods: a) Perturb-Seq screen and an b) arrayed screen We determined the minimum number of cells per sgRNA needed to cover the full complexity of the pooled library for the Perturb-Seq experiment Analysis was carried out using a transcription profiling assay for the arrayed screen vs CellRanger soft...
Mapping Long Noncoding RNA Dependencies in Tumor Cells; by Eugenio Morelli M.D.
Просмотров 4232 года назад
A fundamental question in cancer biology is to define the key oncogenic features of long non-protein coding RNAs (lncRNAs). These regulatory RNA molecules can exert function at multiple levels, from DNA replication to transcriptional and translational control, affecting all aspects of cellular biology. Remarkably, cancer cells can become dependent on specific lncRNAs for their growth and surviv...
Immunophenotyping of T and B-Cell Receptors; by Alex Chenchik, President, Cellecta, Inc
Просмотров 4802 года назад
T-cell receptor (TCR) and B-cell receptor (BCR) repertoire profiling holds great potential for understanding the disease mechanisms and development of new therapeutics for infectious disease, auto-immunity and immuno-oncology applications. However, this potential could be greatly improved by combining information about receptor clonotypes with immunophenotypes of T and B cells. To facilitate th...
Development of a multitarget therapy for prostate cancer; by Maria J. Ruiz-Echevarria, PhD
Просмотров 1332 года назад
Development of a multitarget therapy for prostate cancer; by Maria J. Ruiz-Echevarria, PhD
Flexible & Scalable Genetic Screens for Novel Therapeutic Target Discovery- Overview of Case Studies
Просмотров 3192 года назад
Flexible & Scalable Genetic Screens for Novel Therapeutic Target Discovery- Overview of Case Studies
Spatial Transcriptomics: Uses and Limitations of a Powerful Technique
Просмотров 4,5 тыс.2 года назад
Spatial Transcriptomics: Uses and Limitations of a Powerful Technique
Immunophenotyping of TCR and BCR Clonotypes
Просмотров 6822 года назад
Immunophenotyping of TCR and BCR Clonotypes
Improving and Optimizing Sequencing Workflows
Просмотров 1493 года назад
Improving and Optimizing Sequencing Workflows
Phenotypic screening hit target deconvolution using CRISPR/Cas9 screening technology | AAPS 2021
Просмотров 8493 года назад
Phenotypic screening hit target deconvolution using CRISPR/Cas9 screening technology | AAPS 2021
CRISPR 2.0-Functional CRISPR screening and Cell Barcoding by Paul Diehl
Просмотров 4043 года назад
CRISPR 2.0-Functional CRISPR screening and Cell Barcoding by Paul Diehl
Functional genomics for insights into intra-tumoral vulnerability-J Rose & S Srinivasan MD Anderson
Просмотров 1453 года назад
Functional genomics for insights into intra-tumoral vulnerability-J Rose & S Srinivasan MD Anderson
Lineage Tracing to Dissect Functional Heterogeneity of Tumor Cells; by Sahil Seth, MD Anderson
Просмотров 4423 года назад
Lineage Tracing to Dissect Functional Heterogeneity of Tumor Cells; by Sahil Seth, MD Anderson
Cell barcoding, genetic screens, and expression profiling at a single-cell level; by Alex Chenchik
Просмотров 1903 года назад
Cell barcoding, genetic screens, and expression profiling at a single-cell level; by Alex Chenchik
CRISPRa Tools for Gain-of-Function Genetic Screens, by Nadya Isachenko
Просмотров 1853 года назад
CRISPRa Tools for Gain-of-Function Genetic Screens, by Nadya Isachenko
ARID1A determines luminal identity & therapeutic response in ER+ breast cancer; by Guotai Xu, MSKCC
Просмотров 3204 года назад
ARID1A determines luminal identity & therapeutic response in ER breast cancer; by Guotai Xu, MSKCC
CRISPR/Cas9 screens to investigate mechanisms of cancer drug resistance; by Guotai Xu, MSKCC
Просмотров 4954 года назад
CRISPR/Cas9 screens to investigate mechanisms of cancer drug resistance; by Guotai Xu, MSKCC
In vivo functional cancer genomics using barcoded CRISPR libraries; by Ian P. Winters, D2G Oncology
Просмотров 3235 лет назад
In vivo functional cancer genomics using barcoded CRISPR libraries; by Ian P. Winters, D2G Oncology
Efficient tools to enable drug target and biomarker discovery, by Paul Diehl
Просмотров 1925 лет назад
Efficient tools to enable drug target and biomarker discovery, by Paul Diehl

Комментарии

  • @alexlu2023
    @alexlu2023 7 месяцев назад

    i like the way he connects slides

  • @hbb21st
    @hbb21st Год назад

    Wow, nice course!

  • @sudipaich7617
    @sudipaich7617 3 года назад

    Can we remove genetic dark circles with crispr

  • @StephenGoodfellow
    @StephenGoodfellow 5 лет назад

    Posted at facebook.com/groups/crisper/ CRISPR Facebook Forum : Articles, Papers, Video, Podcasts, Webinars, Discussion - 5,628 Members

  • @StephenGoodfellow
    @StephenGoodfellow 5 лет назад

    Posted at facebook.com/groups/crisper/ CRISPR Facebook Forum : Articles, Papers, Video, Podcasts, Webinars, Discussion - 5,628 Members