- Видео 115
- Просмотров 28 249
Ketamine International Journal Club and Conference
Великобритания
Добавлен 15 мар 2021
Ketamine & Related Compounds International Journal Club.
Founded November 2020 in Oxford, UK.
Upcoming events:
Oxford Ketamine Conference March 25-27th, 2024 - Programme to be announced in November 2023.
Past events:
Ketamine2022 - International Hybrid Conference, April 4th - 6th, 2022.
Ketamine2021 - Virtual Conference. March 25th-26th, 2021.
Independent of industry funding.
Programmed and run by academic clinicians at Oxford and psychiatric trainees.
Recently published papers on ketamine and related compounds for the treatment of psychiatric disorders.
Intended audience: clinicians, clinical and pre-clinical scientists, industry, policy makers.
Organisers:
Rupert McShane, Consultant Psychiatrist and Associate Professor, Oxford, UK
Sara Costi, Wellcome Trust Doctoral Fellow, Department Psychiatry, University of Oxford, Oxford, UK
Jacek Lindner, Clinical Fellow, Psychiatry Trainee, Oxford Health NHS Foundation Trust, Oxford UK
Founded November 2020 in Oxford, UK.
Upcoming events:
Oxford Ketamine Conference March 25-27th, 2024 - Programme to be announced in November 2023.
Past events:
Ketamine2022 - International Hybrid Conference, April 4th - 6th, 2022.
Ketamine2021 - Virtual Conference. March 25th-26th, 2021.
Independent of industry funding.
Programmed and run by academic clinicians at Oxford and psychiatric trainees.
Recently published papers on ketamine and related compounds for the treatment of psychiatric disorders.
Intended audience: clinicians, clinical and pre-clinical scientists, industry, policy makers.
Organisers:
Rupert McShane, Consultant Psychiatrist and Associate Professor, Oxford, UK
Sara Costi, Wellcome Trust Doctoral Fellow, Department Psychiatry, University of Oxford, Oxford, UK
Jacek Lindner, Clinical Fellow, Psychiatry Trainee, Oxford Health NHS Foundation Trust, Oxford UK
055.Predicting non-response to ketamine for depression: An exploratory symptom-level analysis
Ketamine helps some patients with treatment resistant depression (TRD), but reliable methods for predicting which patients will, or will not, respond to treatment are lacking. Herein, we aim to inform prediction models of non-response to ketamine/esketamine in adults with TRD. This is a retrospective analysis of PHQ-9 item response data from 120 patients with TRD who received repeated doses of intravenous racemic ketamine or intranasal eskatamine in a real-world clinic. Regression models were fit to patients’ symptom trajectories, showing that all symptoms improved on average, but depressed mood improved relatively faster than low energy. Principal component analysis revealed a first prin...
Просмотров: 121
Видео
54.Clinical predictive factors and trajectories of suicidal remission over 6 weeks following intrave
Просмотров 1156 месяцев назад
Ketamine is efficient for short-term reduction of suicidal ideas. Predictive factors and outcome trajectories are poorly characterized. Methods: Secondary analyses were conducted on the KETIS study (Abbar et al. BMJ 2022): 156 suicidal patients were randomized to two intravenous infusions of racemic ketamine (0.5 mg/kg) or placebo. Response or remission was assessed over six weeks based on the ...
53. Exploring Predictors of Ketamine Response in Adolescent Treatment-Resistant Depression
Просмотров 2658 месяцев назад
Ketamine has proved effective as a rapid-acting antidepressant agent, but treatment is not effective for everyone (approximately a quarter to a half of patients). Some adult studies have begun to investigate predictors of ketamine’s antidepressant response, but no studies have examined this in adolescents with depression. Methods: We conducted a secondary data analysis of adolescents who partic...
52. Preliminary evidence that ketamine alters anterior cingulate resting-state functional connectivi
Просмотров 2229 месяцев назад
Activity changes within the anterior cingulate cortex (ACC) are implicated in the antidepressant effects of ketamine, but the ACC is cytoarchitectonically and functionally heterogeneous and ketamine’s effects may be subregion specific. In the context of a double- blind randomized placebo-controlled crossover trial investigating the clinical and resting-state fMRI effects of intravenous ketamine...
51. Three daily intraperitoneal injections of sub-anesthetic ketamine ameliorate activity-based anor
Просмотров 6910 месяцев назад
Objective: To identify ketamine's dosing schedule that ameliorates voluntary food restriction, hyperactivity and body weight loss of adult mice undergoing activitybased anorexia (ABA), an animal model of anorexia nervosa. Method: Female and male C57BL6 mice underwent three cycles of ABA, starting from mid-adolescence. ABA vulnerability was compared within and across two groups of animals: those...
50. Ketamine uropathy: Clinical experience in a high prevalence center
Просмотров 32911 месяцев назад
Ketamine uropathy causes inflammatory changes to the urothelium, manifesting as significant lower urinary tract symptoms, small bladder capacity, and pelvic pain. Upper tract involvement and hydrone- phrosis can occur. Data from UK centers are limited, and no formal treatment guidelines exist. All patients with ketamine uropathy presenting to our unit over an 11‐year period were identified thro...
49. Randomized Trial of Ketamine Masked by Surgical Anesthesia in Depressed Patients
Просмотров 12711 месяцев назад
Ketamine may have antidepressant properties, but its acute psychoactive effects complicate successful masking in placebo-controlled trials. In a triple-masked, randomized, placebo-controlled trial, 40 adult patients with major depressive disorder were randomized to a single infusion of ketamine (0.5 mg/kg) or placebo (saline) during anesthesia as usual for routine surgery. The primary outcome w...
48. Comparative Effectiveness of Intravenous Ketamine and Intranasal Esketamine in Clinical Practice
Просмотров 25711 месяцев назад
Ketamine has been redeveloped as a rapid-acting antidepressant for treatment-resistant depression (TRD). There is a paucity of literature comparing subanesthetic intravenous (IV) ketamine and US Food and Drug Administration (FDA)-approved intranasal (IN) esketamine for TRD in real-world clinical settings. We compared the efficacy and time to achieve remission/response with repeated ketamine and...
47. Assessment of Initial Depressive State and Pain Relief With Ketamine in Patients With Chronic Re
Просмотров 11511 месяцев назад
Drug management of chronic pain with antidepressants, antiepileptics, and opioids remains inconclusive, as 60% of patients show little improvement, experience adverse effects, and often require other treatment options.1,2 Ketamine, a nonselective N-methyl-D-aspartate receptor (NMDAR) antagonist with anesthetic properties, can relieve chronic pain.3-5 A recent clinical study3 in patients with re...
46.Long term structural and functional neural changes following a single infusion of Ketamine in PTS
Просмотров 10411 месяцев назад
NMDA receptor antagonists have a vital role in extinction, learning, and reconsolidation processes. During the reconsolidation window, memories are activated into a labile state and can be reconsolidated in an altered form. This concept might have significant clinical implications in treating PTSD. In this pilot study we tested the potential of a single infusion of ketamine, followed by brief e...
45. IV ketamine for TRD patients who have failed to respond to transcranial magnetic stimulation
Просмотров 132Год назад
Intravenous ketamine for treatment-resistant depression patients who have failed to respond to transcranial magnetic stimulation: A case series Olivier Payette, Paul Lespérance, Véronique Desbeaumes Jodoin, Christophe Longpré-Poirier, Laurent Elkrief, Maxime Richard, Nicolas Garel, Jean-Philippe Miron. J Affect Disord. 2023 Apr 17;333:18-20. doi: 10.1016/j.jad.2023.04.019. Epub ahead of print. ...
44. Changes in white matter microstructure following serial ketamine infusions in TRD
Просмотров 242Год назад
Changes in white matter microstructure following serial ketamine infusions in treatment resistant depression Brandon Taraku, Roger P. Woods, Michael Boucher, Randall Espinoza, Mayank Jog, Noor Al-Sharif, Katherine L. Narr, Artemis Zavaliangos-Petropulu. Hum Brain Mapp. 2023 Apr 15;44(6):2395-2406. doi: 10.1002/hbm.26217. Epub 2023 Jan 30. PMID: 36715291; PMCID: PMC10028677. Presenter: Artemis Z...
43. Delayed changes in glutamate levels & functional connectivity with network effects of S-ketamine
Просмотров 233Год назад
Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine Lena Vera Danyeli, Zümrüt Duygu Sen, Lejla Colic, Lisa Kurzweil, Sabrina Gensberger-Reigl, Tamar Macharadze, Florian Götting, Alexander Refisch, Thomas Liebe, Tara Chand, Moritz Kretzschmar, Gerd Wagner, Nils Opel, Fabrice Jollant, Oliver Speck, Matthias H. J. Munk...
42. Characterizing brain dynamics during ketamine-induced dissociation & interactions with propofol
Просмотров 144Год назад
Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology Fangyun Tian, Laura D Lewis, David W Zhou, Gustavo A Balanza, Angelique C Paulk, Rina Zelmann, Noam Peled, Daniel Soper, Laura A Santa Cruz Mercado, Robert A Peterfreund, Linda S Aglio, Emad N Eskandar, G Rees Cosgrove, Ziv M Williams, R Mark Rich...
41. Sympathetic Blocks as Predictor for Response to Ketamine Infusion in Complex Regional Pain synd
Просмотров 238Год назад
Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study Steven P Cohen, Chachrit Khunsriraksakul, Yongjae Yoo, Evan Parker, Christelle D K Samen-Akinsiku, Nirav Patel, Seffrah J Cohen, Xiaoning Yuan, Jianguo Cheng, Jee Youn Moon. Pain Med. 2023 Mar 1;24(3):316-324. doi: 10.1093/pm/pnac153. PMID: 36269190. Presenter...
40. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder
Просмотров 1,3 тыс.Год назад
40. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder
39. Real-world effectiveness of repeated ketamine infusions for Tx resistant bipolar depression
Просмотров 480Год назад
39. Real-world effectiveness of repeated ketamine infusions for Tx resistant bipolar depression
38. Patients' recovery and non-recovery narratives after IV ketamine for TRD
Просмотров 256Год назад
38. Patients' recovery and non-recovery narratives after IV ketamine for TRD
37. IV ketamine for depression: best practices in acute hypertension management
Просмотров 305Год назад
37. IV ketamine for depression: best practices in acute hypertension management
36. Evaluation of Early Ketamine Effects on Belief-Updating Biases in Patients With TRD
Просмотров 145Год назад
36. Evaluation of Early Ketamine Effects on Belief-Updating Biases in Patients With TRD
35. Intervention to Extend the Antidepressant Effect of a Single Ketamine Infusion
Просмотров 2512 года назад
35. Intervention to Extend the Antidepressant Effect of a Single Ketamine Infusion
34. Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women
Просмотров 9532 года назад
34. Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women
Paolo Manfredi & Marco Pappagallo - REL-1017 (esmethadone hydrochloride) a novel uncompetitive...
Просмотров 1612 года назад
Paolo Manfredi & Marco Pappagallo - REL-1017 (esmethadone hydrochloride) a novel uncompetitive...
Joshua Rosenblat - Do all types of depression respond similarly? Real-world data on complex...
Просмотров 1752 года назад
Joshua Rosenblat - Do all types of depression respond similarly? Real-world data on complex...
Tuuli Hiematies & Alison McInnes - Osmind real-world ketamine analyses
Просмотров 1252 года назад
Tuuli Hiematies & Alison McInnes - Osmind real-world ketamine analyses
David Monks - Ketamine to prevent postpartum depression after planned cesarean delivery under...
Просмотров 562 года назад
David Monks - Ketamine to prevent postpartum depression after planned cesarean delivery under...
Sanne Smith-Apeldoorn & Jolien Veraart - Oral esketamine for TRD: results of a randomized...
Просмотров 1632 года назад
Sanne Smith-Apeldoorn & Jolien Veraart - Oral esketamine for TRD: results of a randomized...
Esther Hagai - CLE-100: an oral esketamine for daily at home administration
Просмотров 1732 года назад
Esther Hagai - CLE-100: an oral esketamine for daily at home administration
Robert Schoevers - Holding on or letting go? A qualitative study into patient experiences of...
Просмотров 932 года назад
Robert Schoevers - Holding on or letting go? A qualitative study into patient experiences of...
Zach Thomas - Rapid antidepressant effects and MADRS symptom improvements with AXS-05, an oral NMDA
Просмотров 2372 года назад
Zach Thomas - Rapid antidepressant effects and MADRS symptom improvements with AXS-05, an oral NMDA