The Antibody Society
The Antibody Society
  • Видео 124
  • Просмотров 54 996
Accelerating Antibody Discovery with the Human Antibody Mouse HUGO-Ab + HTP Single B Cell Screening
In this webinar, Dr. Shun Zhou explores the revolutionary potential of the genome-edited mouse HUGO-Ab, where endogenous VH and VL genes are replaced by fully human VH and VL genes in situ, enabling the generation of fully human antibody molecules. When combined with microfluidic technology-enhanced single B cell screening, this approach allows for the high-throughput and efficient discovery of antibody drug molecules.
About the speaker
Shun Zhou holds a Ph.D. Molecular Biology and Genetics from the Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, and was a Postdoctoral Fellow in the Department of Biomedical Engineering at Tufts University, USA. With over 10 years of...
Просмотров: 115

Видео

Advancing bispecific discovery programs towards clinical success using GS Discovery® and bYlok®
Просмотров 162Месяц назад
In this webinar Dr. Jin Lu shows how Lonza’s novel GS Discovery® transient expression platform can boost transient titers by ~30-fold to enable rapid early material supply, and streamline the transition from discovery to stable production. Dr. Lu will also introduce bYlok® bispecific pairing technology - an innovative solution that drives correct heavy-light chain pairing rates in IgG-like bisp...
Interview with Gabriel Emilio Herrera Oropeza (King’s College London)
Просмотров 812 месяца назад
Gabriel Emilio Herrera Oropeza's image “Structure of an Unpatterned Cerebral Organoid” was a winning entry in our 2023 Imaging Calendar Competition, and included as the April image in the 2024 Society calendar.
Harnessing Divergent Species to Access Difficult and Conserved Antibody Targets
Просмотров 2453 месяца назад
To exploit highly conserved and difficult drug targets, including GPCRs and ion channels, monoclonal antibody discovery efforts are increasingly relying on the advantages offered by divergent species such as rabbits, camelids, and chickens. Divergent host species enable robust immune responses against highly conserved binding sites and yield antibodies capable of penetrating functional pockets ...
Harnessing the power of ADCs: How the Signals™ Research Suite advances multi-modal drug development
Просмотров 1994 месяца назад
Antibody-drug conjugates (ADCs) have emerged as an important class of targeted therapeutics, combining the targeting specificity of antibodies with the potency of cytotoxic drugs. Recent advances in ADC research have led to improved stability, efficacy, and safety. There is a clear trend within Antibody therapeutics towards ADCs with the improvement of novel technologies to address a growing ca...
Interview with Danielle Fails
Просмотров 1194 месяца назад
Danielle Fails' image depicting immune profiling of axillary lymph tissues was a winning entry in our 2023 Imaging Competition, and included as the March image in the 2024 Society calendar. If anyone would like to know more about multiplex panel design, instrumentation available, or even get some ideas on various “starter” panels, they can visit: www.fortislife.com/custom-multiplex-imaging Curi...
3D antibody modeling in Orion
Просмотров 4965 месяцев назад
OpenEye’s suite of antibody modeling tools, accessed via the cloud platform Orion, includes Specifica’s state-of-the-art antibody sequence analysis tool AbXtract and open-source tools such as ImmuneBuilder for antibody structure prediction. In this webinar, Dr. Jesper Sorensen will guide viewers through the process of modeling antibody structure on Orion, which begins with taking sequences from...
Antibodies to watch in 2024
Просмотров 7336 месяцев назад
The ‘Antibodies to Watch’ series provides an annual summary of commercially sponsored monoclonal antibody therapeutics currently in late-stage clinical development, regulatory review, and those recently granted a first approval in any country. In this webinar, we discuss key details for antibody therapeutics granted a first approval in 2023. We briefly review product candidates for which market...
IgE Class Antibody Therapeutics for Cancer
Просмотров 3476 месяцев назад
Monoclonal IgE antibodies targeting tumor-associated antigens may mediate potent immune-activating functions in tissues, resulting in anti-tumor activity. Dr. Bax will present in vitro and in vivo functions of two anti-cancer IgEs, associations with monocyte/macrophage polarisation, macrophage infiltration, and enriched pro-inflammatory signatures within tumors, the absence of preliminary evide...
Interview with Dr Federica Riccio - winner of the Imaging Calendar competition
Просмотров 846 месяцев назад
Interview with Dr Federica Riccio (King's College London, UK) - winner of the Imaging Calendar competition, and scientist behind the cover and January image of the 2024 TAbS Calendar.
Exploring TCR-Epitope Prediction Tools: Insights And Pitfalls
Просмотров 8327 месяцев назад
T cells are at the heart of the immune system's ability to distinguish between self and non-self, playing a critical role in both health and disease. The specificity of the T-cell response is mediated by the T-cell receptor (TCR), a product of the unique V(D)J recombination process, which enables interaction with a wide variety of antigens. Given the sheer scale of potential TCR-epitope interac...
Strategies for Mitigating the Unpredictability of Fc-Mediated Functions in Antibody Development
Просмотров 8428 месяцев назад
Optimization of Fc function can lead to the development of safer and more efficacious therapeutic antibody products, but analyses of Fc function may be underexploited in the antibody design process. We introduce a high-throughput platform for antigen-specific testing of Fc effector activities, empowering enhanced hit-to-lead screening in early stages of antibody development for the treatment of...
Quality Control Pipelines for T cell and B cell AIRR-seq
Просмотров 4658 месяцев назад
Professors Encarnita Mariotti-Ferrandiz and Nina Luning Prak, members of the Adaptive Immune Receptor Repertoire (AIRR) Community Biological Resources Working Group, discuss quality control (QC) procedures for immune repertoire profiling. Dr. Mariotti-Ferrandiz describes QC pipelines for sequencing of T cell receptor gene rearrangements that are in use in her laboratory in the Department of Imm...
Computational developability profiling of antibody repertoire data: Victor Greiff (U. Oslo)
Просмотров 9138 месяцев назад
Computational Antibody Discovery: State of the Art Symposium, June 22, 2023, Computational developability profiling of antibody repertoire data - Victor Greiff Developability, the set of physicochemical properties of an antibody relevant for manufacturing and success in clinical trials, is one of the key determinants for success during clinical testing and any developability parameters can be c...
Versatility of Modular Antibodies: Rapid Format Switch to Fast Screening of Libraries & Bispecifics
Просмотров 4589 месяцев назад
The SpyTag/SpyCatcher protein ligation technology is a versatile method to covalently link two proteins. Addition of the SpyTag protein ligation technology to antibodies creates a modular platform that offers a wide range of new opportunities. In this webinar Dr. Ylera will demonstrate the use of Spytagged antibodies in combination with prefabricated SpyCatcher modules for rapid site-specific l...
Antibody Validation Challenges
Просмотров 1339 месяцев назад
Antibody Validation Challenges
Trends in the commercial development of antibody therapeutics: The early-stage clinical pipeline
Просмотров 7309 месяцев назад
Trends in the commercial development of antibody therapeutics: The early-stage clinical pipeline
Multiple Innovative Technologies & Platforms Empower Antibody Discovery
Просмотров 73410 месяцев назад
Multiple Innovative Technologies & Platforms Empower Antibody Discovery
Comparing Bispecific Antibody Format Feasibility
Просмотров 1,5 тыс.11 месяцев назад
Comparing Bispecific Antibody Format Feasibility
Computational Antibody Discovery Symposium: Panel discussion summary
Просмотров 392Год назад
Computational Antibody Discovery Symposium: Panel discussion summary
Computational Antibody Discovery Symposium: Tzvika Hartman (Biolojic Design)
Просмотров 910Год назад
Computational Antibody Discovery Symposium: Tzvika Hartman (Biolojic Design)
Computational Antibody Discovery Symposium: Introduction, Pietro Sormanni (University of Cambridge).
Просмотров 1,5 тыс.Год назад
Computational Antibody Discovery Symposium: Introduction, Pietro Sormanni (University of Cambridge).
Computational Antibody Discovery Symposium: Closing remarks by Andrew Buchanan (AstraZeneca)
Просмотров 271Год назад
Computational Antibody Discovery Symposium: Closing remarks by Andrew Buchanan (AstraZeneca)
Computational Antibody Discovery Symposium: Ben Holland (CTO, Antiverse)
Просмотров 920Год назад
Computational Antibody Discovery Symposium: Ben Holland (CTO, Antiverse)
Computational Antibody Discovery Symposium: Dr. Sandeep Kumar
Просмотров 585Год назад
Computational Antibody Discovery Symposium: Dr. Sandeep Kumar
IgM Antibodies and Other Alternative Frameworks: Promise and Progress
Просмотров 841Год назад
IgM Antibodies and Other Alternative Frameworks: Promise and Progress
The Antibody Society James S. Huston Winner 2022 - Dr Brandon DeKosky
Просмотров 224Год назад
The Antibody Society James S. Huston Winner 2022 - Dr Brandon DeKosky
Dissecting human B cell responses induced by heterologous SARS-CoV-2 exposure
Просмотров 256Год назад
Dissecting human B cell responses induced by heterologous SARS-CoV-2 exposure
Trends in the early-stage clinical development of antibody therapeutics
Просмотров 555Год назад
Trends in the early-stage clinical development of antibody therapeutics
Setting up Rep-Seq for antibodies: There and back again
Просмотров 375Год назад
Setting up Rep-Seq for antibodies: There and back again