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02. Scott Falci: Novel Approaches to Understanding and Treating Spinal Cord Injury Neuropathic Pain
Neuropathic pain is among the most disabling sequelae of spinal cord injuries (SCIs), with prevalence estimated from 65-80%. Common pain descriptors include “sharp, burning, electrical, stabbing, pins-and-needles, squeezing, pressure” sensations. These pains are always perceived in body regions of partial or complete sensory loss from the SCI. Scientific understanding of these pain perceptions has been perplexing, particularly in individuals experiencing these pains in regions of the body of complete paralysis, who are otherwise unable to detect any painful stimulus-no matter how severe-to that paralyzed body region. Historically, failed attempts to treat this pain through spinal cord tra...
Просмотров: 122
Видео
005: Chris Lunt: Discovery Through Scale. The All of Us Research Program
Просмотров 245 месяцев назад
The NIH All of Us Research Program is working to advance precision medicine by building the largest, most diverse biomedical data resource in the world. Launched in May 2018, All of Us seeks to gather health data from one million or more participants across the United States, representing a wide array of backgrounds, ages, geographic regions, and health statuses. All of Us has more than 750k co...
008: Alex Morgan: Ten Years to Be an Overnight Success: Investing in the Future Takes Time
Просмотров 405 месяцев назад
The path to significant innovation and change can be long, but if you work on major problems creatively and hard enough, you can have a major impact. Khosla Ventures has been actively investing in a number of areas in biology and medicine over the last decade that are now poised to improve the world in a variety of ways. These include efforts in neurotechnology, fetal-maternal medicine, tissue ...
007. Max Bennet: The Evolution of Human Intelligence
Просмотров 1,8 тыс.5 месяцев назад
The Evolution of Human Intelligence: Why it Matters and What It Teaches Us About Ourselves, Neuroscience, and AI In this talk, Bennett will review the research and key conclusions in his new book A Brief History of Intelligence: Evolution, AI, and the Five Breakthroughs That Made Our Brains. Despite centuries of effort, we still do not understand how the human brain works. The brain is full of ...
006. John Wilbanks: A Small Matter of (Scientific) Programming
Просмотров 345 месяцев назад
Why is it so hard for scientists in healthcare and biology to command programming power? Data has dominated the field for decades, and wave after wave of scientists have been exciting graduate students trained in informatics at some level. However, the field has (so far) successfully resisted network effects in data and systemic end-user programming as a day-to-day practice. If we are going to ...
004. Julie Gerberding: Re-Earning Trust in Science: A Health Imperative
Просмотров 405 месяцев назад
The rapid pace of biomedical research insights and their translation into new diagnostics and treatments have enormous potential to improve health and well-being. Yet, despite the promise of these discoveries, preventable mortality is actually increasing, in part because too many people are unwilling or unable to take advantage of them. One major obstacle to uptake is the erosion of trust - tru...
10. Larry Gold: Broad Proteomics and Health Management
Просмотров 615 месяцев назад
More than a decade ago, SomaLogic published the first paper to accurately quantify the concentrations of many human proteins (epitopes really, since we used as binding reagents SOMAmers/aptamers that contacted a small domain of a target protein - about a thousand square angstroms or so). The emphasis since that early paper has been on expanding the number of proteins measured (now at more than ...
002. Colin Hill: Digital Twins and the Discovery of New Drugs for Rare Diseases
Просмотров 885 месяцев назад
The emergence of combined multi-omic and clinical data directly from patient tissue, along with the availability of ultra-scale computing, and recent developments in AI that can reverse-engineer causal mechanisms from observational data, have converged to enable the creation of Gemini Digital Twins, replicas of human disease biology. Gemini Digital Twins are computational representations of hum...
09. Hamilton Oh: Young Blood for Old Brains
Просмотров 345 месяцев назад
Aging leads to the degradation of function and the onset of diseases in nearly all tissues and organs. Our research has been centered on brain aging, which results in cognitive decline and is a major risk factor for sporadic neurodegenerative diseases such as Alzheimer's. While brain cell- and tissue-intrinsic factors are likely essential in driving the aging process, recent studies document a ...
08. Dayna Matthew: What To Do When The Law is Bad For Your Patients’ Health
Просмотров 325 месяцев назад
Access to a good education has empirically been shown to significantly increase one's chances of enjoying good health. Conversely, a poor education virtually guarantees poor health outcomes. Yet, over the past half-century, the United States Supreme Court has steadily marched away from the guarantees of equal educational opportunity for underrepresented children, and thus marched deliberately t...
07. Duey Freeman: Exploring Attachment: The Foundation of Our Relational Lives
Просмотров 1245 месяцев назад
The pervasiveness and effects of trauma are well represented in many helping and scientific professions. In fact, these professions are currently expected to be ‘trauma-informed.’ What is under-represented and more foundational to the emotional health of individuals, families, and communities is the quality of our early, original attachment. This bond provides the blueprint for all relationship...
003. Keolu Fox: Guns, Germs, and Alleles
Просмотров 455 месяцев назад
In the following lecture, we will explore three key topics related to Oceania, using genomic data and modeling studies to illuminate historical migrations, disease origins, and health trends in the Pacific region. 1. Peopling of Polynesia: Genomic Insights: This segment examines the migration pathways to Polynesia, leveraging genomic networks to delineate the timing and routes of these ancient ...
000: Larry Hunter: Day 2 Opening Remarks
Просмотров 45 месяцев назад
This symposium is always one of my favorite events of the year. Time with old friends, learning interesting new things, and the opportunity to work closely with Meredith and Larry to organize these events brings me such joy. One of the things that makes this meeting so unusual is the fact that previous speakers keep coming back, sometimes as moderators, and sometimes just to listen and join the...
06. Session 1 Roundtable Discussion of Pain
Просмотров 135 месяцев назад
06. Session 1 Roundtable Discussion of Pain
05. Adina Michael-Titus: Omega-3 Fatty Acids for Treatment of Spinal Cord & Traumatic Brain Injuries
Просмотров 325 месяцев назад
Traumatic neurological injury can be an event with life-changing consequences. When injury occurs in the central nervous system, there are major obstacles to regenerative processes, therefore, recovery of function is limited. At present, there are no clinical interventions that support the patient by providing neuroprotection in the immediate aftermath of injury, or specific treatments in the c...
04. Ru Rong Ji: Using Omega-3 Fatty Acid Molecular Pathways to Block Inflammatory & Neuropathic Pain
Просмотров 485 месяцев назад
04. Ru Rong Ji: Using Omega-3 Fatty Acid Molecular Pathways to Block Inflammatory & Neuropathic Pain
03. Richard Deckelbaum: Omega-3 Fatty Acids: New Frontiers
Просмотров 1025 месяцев назад
03. Richard Deckelbaum: Omega-3 Fatty Acids: New Frontiers
01. Glenn Treisman: Chronic Pain and Pain Amplification: Seeing the Whole Elephant
Просмотров 1675 месяцев назад
01. Glenn Treisman: Chronic Pain and Pain Amplification: Seeing the Whole Elephant
00. Larry Gold: Day 1 Opening Remarks
Просмотров 135 месяцев назад
00. Larry Gold: Day 1 Opening Remarks
09 Andreas Beyer & Argyris Papantonis: Living in the Fast Lane + Closing Remarks - Larry Hunter
Просмотров 379Год назад
09 Andreas Beyer & Argyris Papantonis: Living in the Fast Lane Closing Remarks - Larry Hunter
08. Karolin Luger: Genomes Packaged to Perfection, in All Domains of Life
Просмотров 206Год назад
08. Karolin Luger: Genomes Packaged to Perfection, in All Domains of Life
07 Nicholas Tatonetti: AI-Driven Biomedical Discoveries Using Observational Data
Просмотров 245Год назад
07 Nicholas Tatonetti: AI-Driven Biomedical Discoveries Using Observational Data
06 Larry Hunter: Five Questions About Generative AI and Health
Просмотров 246Год назад
06 Larry Hunter: Five Questions About Generative AI and Health
05. Lex Van der PloegThe Language of Song: AI-Powered RIFFIT Enhances Communication and Learning
Просмотров 70Год назад
05. Lex Van der PloegThe Language of Song: AI-Powered RIFFIT Enhances Communication and Learning
04. Jack Gallant: Decoding Brains - Imaging to Advance Mental Health
Просмотров 368Год назад
04. Jack Gallant: Decoding Brains - Imaging to Advance Mental Health
03. Michelle Holko: Wearable Sensors and the Future of Heath
Просмотров 135Год назад
03. Michelle Holko: Wearable Sensors and the Future of Heath
Opening Remarks + Phil Fernbach GLS2023 Day 2
Просмотров 90Год назад
Opening Remarks Phil Fernbach GLS2023 Day 2
08. Roland Baron: From Rare Diseases of the Skeleton to Treatment for All, and Back.
Просмотров 212Год назад
08. Roland Baron: From Rare Diseases of the Skeleton to Treatment for All, and Back.
09 Lauren Rosenberg: The Story of Sophie’s Neighborhood: Moving Mountains for MCTO.
Просмотров 106Год назад
09 Lauren Rosenberg: The Story of Sophie’s Neighborhood: Moving Mountains for MCTO.
07. Peter McGraw: Living Single in a World Built for Two
Просмотров 409Год назад
07. Peter McGraw: Living Single in a World Built for Two