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CoskunLabGT
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Добавлен 9 дек 2019
Spatial Biology of Tumor Microenvironments for Clinical Biomarker Development and Therapy Prediction
Alex is currently an Instructor at Cedars-Sinai Medical Center and an incoming Assistant Professor of Bioengineering at the University of Maryland. He is also the Associate Director of the Spatial Molecular Profiling Core Facility at Cedars-Sinai. His research focuses on studying the spatial biology of the tumor immune microenvironment in order to propose novel biomarkers to predict clinical outcomes, and novel therapies to improve clinical outcomes.
Cancer, once thought to be a disease defined by simple oncogenes, has shown itself to carry an incredible amount of baggage. Baggage such as immune dysregulation, stromal signaling, metabolic reprogramming, and other "hallmarks" that make canc...
Cancer, once thought to be a disease defined by simple oncogenes, has shown itself to carry an incredible amount of baggage. Baggage such as immune dysregulation, stromal signaling, metabolic reprogramming, and other "hallmarks" that make canc...
Просмотров: 386
Видео
Illuminating transcriptomic dark matter with new spatial technologies
Просмотров 1023 месяца назад
Spatial transcriptomics reveals the histological context of gene expression, but most methods only capture poly(A)-tailed transcripts. This limits detection to a narrow slice of the transcriptome. Undetected transcriptomic dark matter contains a wide variety of RNA molecules which play important roles in gene regulation. Capturing the entire transcriptome, including both coding and noncoding RN...
Visual-language model for digital pathology and clinical decision-making
Просмотров 4193 месяца назад
Zhi Huang is a postdoc at Stanford University. In August 2021, he received his Ph.D. degree from Purdue University, majoring in Electrical and Computer Engineering (ECE). Prior to that, he received his Bachelor of Science degree in Electronic and Information Engineering (BS-MS direct entry class) from Xi’an Jiaotong University. His background is in the area of Artificial Intelligence, Human-AI ...
SPACEc: A Streamlined, Interactive Python Workflow for Multiplexed Image Processing and Analysis
Просмотров 5384 месяца назад
Spatially resolved multiplexed imaging data analysis unveils insights into intricate spatially organized niches and tissue architectures. Existing hurdles in this field encompass software fragmentation, processing bottlenecks for large images, and a dearth of computational workflows for comparing experimental setups. To tackle these challenges, we introduce SPACEc, a Python-based end-to-end wor...
MorphLink: Bridging Cellular Morphological Behaviors and Molecular Dynamics in Spatial Omics
Просмотров 5624 месяца назад
Jian Hu, PhD, is an Assistant Professor at the Department of Human Genetics with a joint appointment in the Department of Biostatistics and Bioinformatics at Emory University. He is also a member of Emory’s AI Humanity initiative. Hu’s research program involves two synergistic components: 1) a methodological component focuses on developing novel statistical methods for biomedical data, includin...
Spatial Omics Mapping of Human Brain Disorders
Просмотров 5055 месяцев назад
Dr. Yang Xiao is a postdoctoral researcher in Biomedical Engineering at Columbia University. She earned her Bachelor’s degree in Molecular Biology at McGill University and pursued her Ph.D. in Biomedical Engineering at Yale University. Under the mentorship of Prof. Rong Fan, Dr. Xiao conducted her doctoral research on brain tumor invasion in the perivascular niche. Employing advanced techniques...
From Bedside to Bench Using Spatial Analysis
Просмотров 1325 месяцев назад
Dr. Camilla (Margaroli) Bell received her master degree in Medical Biology at the University of Lausanne (Switzerland) in 2015, and her PhD in Immunology and Molecular Pathogenesis in 2019 from the Graduate Division of Biological and Biomedical Sciences at Emory University (Atlanta, GA). During her thesis in Dr. Tirouvanziam’s group, Dr. Bell studied the mechanisms leading to neutrophil plastic...
From Molecules to Multicell Modules: Immune-Mediated Tissue Restructuring
Просмотров 1 тыс.6 месяцев назад
Speaker: John Wirthlin Hickey, PhD Advancements in single-cell multiplexed imaging coupled with sophisticated computational algorithms have greatly augmented our views into complex tissue microenvironments. In this talk, I will present the approaches we have developed to deconstruct intricate tissue datasets and connect them across scales from molecular to multicell modules. Particularly, I wil...
Imaging-based genetic recording of developmental history
Просмотров 3842 года назад
Speaker: Amjad Askary, Molecular, Cell and Developmental Biology, University of California, Los Angeles Virtual seminar series for Spatial Omics, organized by Prof. Rong Fan and Prof. Ahmet Coskun To know more, check: spatialomics.net/
Computational approaches to mapping structure in tissues
Просмотров 6682 года назад
Speaker: Dana Pe'er, Sloan Kettering Institute Virtual seminar series for Spatial Omics, organized by Prof. Rong Fan and Prof. Ahmet Coskun To know more, check: spatialomics.net/
Spying on microbial populations via transcriptome imaging
Просмотров 2622 года назад
Speaker: Daniel Dar, Dept. Plant & Environmental sciences, Weizmann Institute of Science Virtual seminar series for Spatial Omics, organized by Prof. Rong Fan and Prof. Ahmet Coskun To know more, check: spatialomics.net/
Finding Order in Chaos: Advancements in Tumor Heterogeneity using Spatial Proteomics
Просмотров 4832 года назад
Speaker: Fiona Ginty, Biology & Applied Physics, GE Research Virtual seminar series for Spatial Omics, organized by Prof. Rong Fan and Prof. Ahmet Coskun To know more, check: spatialomics.net/
Generating a spatial atlas of the healthy and obese liver across species
Просмотров 6152 года назад
Speaker: Charlotte Scott, VIB and Univ of Gent Virtual seminar series for Spatial Omics, organized by Prof. Rong Fan and Prof. Ahmet Coskun To know more, check: spatialomics.net/
Multimodal in situ analysis of single-cell transcriptional states
Просмотров 2,7 тыс.2 года назад
Speaker: Xiao Wang, MIT Chemistry and Broad Institute Virtual seminar series for Spatial Omics, organized by Prof. Rong Fan and Prof. Ahmet Coskun To know more, check: spatialomics.net/
Learning spatial components of molecular tissue biology
Просмотров 5502 года назад
Speaker: Fabian Theis, Helmholtz Munich, TU Munich and Wellcome Trust Sanger Institute Virtual seminar series for Spatial Omics, organized by Prof. Rong Fan and Prof. Ahmet Coskun To know more, check: spatialomics.net/
Level up immune profiling of the tumor microenvironment - deep phenotyping and target discovery
Просмотров 7392 года назад
Level up immune profiling of the tumor microenvironment - deep phenotyping and target discovery
Spatially resolved proteogenomic characterization of the tumor micro-environment in FFPE tissues
Просмотров 3692 года назад
Spatially resolved proteogenomic characterization of the tumor micro-environment in FFPE tissues
SPICEMIX: Integrative single-cell spatial modeling for inferring cell identity
Просмотров 5862 года назад
SPICEMIX: Integrative single-cell spatial modeling for inferring cell identity
Neural Network Physiology + Spatial Transcriptomics (Speaker: Jerry Chen)
Просмотров 4232 года назад
Neural Network Physiology Spatial Transcriptomics (Speaker: Jerry Chen)
Enhanced Electric FISH (Speaker: Sten Linnarsson, Karolinska Institutet)
Просмотров 8082 года назад
Enhanced Electric FISH (Speaker: Sten Linnarsson, Karolinska Institutet)
High-resolution multiplexed chemical imaging in cells and tissues (Speaker: Lu Wei, Caltech)
Просмотров 1,1 тыс.2 года назад
High-resolution multiplexed chemical imaging in cells and tissues (Speaker: Lu Wei, Caltech)
Integration of Single Cell Spatial Technologies enables Granular Characterization of COVID-19
Просмотров 5172 года назад
Integration of Single Cell Spatial Technologies enables Granular Characterization of COVID-19
Regulation of the immune response through microanatomy and cellular patterning
Просмотров 9142 года назад
Regulation of the immune response through microanatomy and cellular patterning
NanoPOTS technologies for single-cell and spatial proteomics (Speaker: Ying Zhu, PNNL)
Просмотров 1 тыс.2 года назад
NanoPOTS technologies for single-cell and spatial proteomics (Speaker: Ying Zhu, PNNL)
Advancing Biology with Spatial Genomics (Speaker: Brian R. Fritz, Spatial Genomics)
Просмотров 8752 года назад
Advancing Biology with Spatial Genomics (Speaker: Brian R. Fritz, Spatial Genomics)
Multimodal Imaging Mass Spectrometry: Advanced Technologies for Molecular Mapping of Tissues
Просмотров 7112 года назад
Multimodal Imaging Mass Spectrometry: Advanced Technologies for Molecular Mapping of Tissues
Genome origami: differentiating cells by bending the blueprints (Speaker: Alistair Boettiger)
Просмотров 5912 года назад
Genome origami: differentiating cells by bending the blueprints (Speaker: Alistair Boettiger)
Single cell & spatial multiplex profiling of immune cell markers in FFPE tumors - RNAscope HiPlex v2
Просмотров 8303 года назад
Single cell & spatial multiplex profiling of immune cell markers in FFPE tumors - RNAscope HiPlex v2
Every Cell Matters! Molecular Cartography, a versatile platform for in situ mRNA quantification
Просмотров 1,3 тыс.3 года назад
Every Cell Matters! Molecular Cartography, a versatile platform for in situ mRNA quantification
Versatile, high-resolution & large field-of-view single molecule imaging by oblique plane microscopy
Просмотров 8923 года назад
Versatile, high-resolution & large field-of-view single molecule imaging by oblique plane microscopy
Nice talk!
wow+
the explanation for seqFISH+ is a little confusing. what are the number 0-20 for each color?
9
Is this the only video of Xiao Wang that's available? her work is wayy more important than to deserve a single video on theinternets
Thanks for sharing!
Do you have instructions on how to build an oplique plane light sheet microscope or is there a commercial one that you can buy?
2:25 instruction manual, environment; senses, umwelt
This was a fascinating talk. I wish we could hear the speaker better.
Very bad that the presentation is obstructed so much. Otherwise its very informational and cool.
20yeas old idea which apply geographic information system to cells. Now it is feasible to implement with single technology and spatial transcriptome.
Very interesting talk. Thank you very much!
This is cool and all but I just beat Malenia in elden ring without using a mimic 😤
OK THIS IS DEFINITELY ONE OF THE BETTER BIOLOGY VIDEOS IN A SEA OF BORING AF VIDEOS
Sk you think that this can be used to detect what hiv rna is doing to different cells in the body?
Huang Qiusheng led me here
What a wonderful introduction to Spatial Transcriptome! Thanks for the speaker who introduce 10X ST, cell2location. But the speaker is using Seurat V3 rather than V4 as an example, I wondering that the V4 would have a better way (WNN) to implement multi-omics integration.
This a specials tool
Absolutely fantastic instrument. Is there any catalogue of imaging that has been done so far available publicly?