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Daniel S.
США
Добавлен 17 май 2013
Hi everyone, my name is Daniel and I am a chemist in the pharmaceutical industry. I decided to create this channel to teach some basic chemistry and science related to drug discovery and pharmaceutical science. I found that the best way to relearn a concept is through teaching.
Feel free to leave any suggestions and questions in the comment section and I will get back to you.
Feel free to leave any suggestions and questions in the comment section and I will get back to you.
Ion Channels as Drug Targets - Medicinal Chemistry 1.18
The ion channel protein family is involved in almost all aspects of life. And because of how important the ion channels are in human physiology, they are related to many diseases and being able to control and regulate the channels become really important. Currently, the ion channel family represents one of the largest target classes for existing drugs.
--About me--
I am a computational chemist in the pharmaceutical industry. I created the Mole Man Chem channel to explain some basic medicinal and biochemistry concepts because I believe the best way to relearn a concept is through teaching.
Feel free to email me with any questions at molemanchem@gmail.com
--Video lists--
Medicinal chemistry pl...
--About me--
I am a computational chemist in the pharmaceutical industry. I created the Mole Man Chem channel to explain some basic medicinal and biochemistry concepts because I believe the best way to relearn a concept is through teaching.
Feel free to email me with any questions at molemanchem@gmail.com
--Video lists--
Medicinal chemistry pl...
Просмотров: 4 322
Видео
G protein-coupled receptors (GPCRs) as Drug Targets - Medicinal Chemistry 1.17
Просмотров 4,9 тыс.Год назад
Drugs that target G-protein coupled receptors or GPCR account for near 30% of the global market share of therapeutic drugs. The high interest and large market share are because of how important GPCRs are in many diseases. Right now, there are over 2000 different mutations in 55 GPCR genes that have been characterized and linked to over 60 human diseases. Based on how those mutations can change ...
Receptors as Drug Targets (An Intro) - Medicinal Chemistry 1.16
Просмотров 6 тыс.2 года назад
Receptors are proteins, that by far, the most important drug targets in medicine. Because of the receptor's role in signal transduction, they are very valuable drug targets for treatment such as pain, depression, and even Parkinson’s disease and many other problems. If we can regulate the receptors, we can potentially regulate the downstream domino effect, or the downstream biological effects t...
Orthosteric Drugs And Allosteric Drugs - Medicinal Chemistry 1.15
Просмотров 3,7 тыс.2 года назад
There are two types of drugs on the market: orthosteric drugs and allosteric drugs. Orthosteric drugs bind at the active site of the target and directly compete with the endogeneous substrate. One example is the ATP competitive inhibitors that directly compete with the binding of ATP. Allosteric drugs bind elsewhere other than the active site or the orthosteric site, and they don’t directly com...
Suicide Substrates/Mechanism-based Inhibitors - Medicinal Chemistry 1.14
Просмотров 10 тыс.2 года назад
Suicide inhibitors or mechanism-based inhibitors are a type of highly-specific irreversible inhibitors that targets and hijacks the normal enzymatic reaction mechanism to inactivate the enzymes. They are relatively unreactive in cells or solution until they bind to the enzyme active site. For most of the irreversible inhibitors, the reactive functional groups are already present when the molecu...
What is medicinal chemistry - Medicinal Chemistry 0.0
Просмотров 28 тыс.2 года назад
Medicinal chemistry focuses on designing, creating and refining molecules and output drug-like agents that can be tested for their abilities to reduce disease-like symptoms in a preclinical and clinical setting. The interdisciplinary subject spans chemistry, biology and pharmacology. The two most important subjects are synthetic organic chemistry and pharmacology. Synthetic chemistry and modern...
Pfizer's NEW COVID-19 antiviral Paxlovid: mechanism of actions, side effects and precautions
Просмотров 18 тыс.2 года назад
The US FDA issued an emergency use authorization for Pfizer’s Covid-19 antiviral, Paxlovid, which is the first COVID-19 antiviral authorized for emergency use in the United States. According to Pfizer's press release, Paxlovid cuts the risk of hospitalization or death for high-risk patients by 89%, based on the clinical trial data. In Paxlovid, there are two antiviral medications: nirmatrelvir ...
Transition State Analogues/Inhibitors - Medicinal Chemistry 1.13
Просмотров 8 тыс.2 года назад
A chemical reaction will go through a high-energy intermediate state called the transition state. One strategy that drug discovery scientists came up with is designing an inhibitor that resembles the structure of the transition state. Also, this inhibitor could potentially bind strongly to the active site, even much stronger than the substrate or the products. This type of inhibitors is called ...
Enzyme Inhibitors (Reversibility and Inhibition Mode) - Medicinal Chemistry 1.12
Просмотров 4,3 тыс.2 года назад
Based on the reversibility, enzyme inhibitors can be categorized into irreversible and reversible inhibitors. Irreversible inhibitors would bind to the enzymes by forming much stronger interactions and “permanently” modify the enzyme. Reversible inhibitor binds to the enzymes by forming relatively weaker interactions or reversible covalent bond. When the inhibition is reversed, often times the ...
How did Pfizer/BioNTech win the COVID-19 vaccine race?
Просмотров 1,1 тыс.2 года назад
As of the beginning of 2022, only three Covid-19 vaccines are authorized or approved for use in the United States. They are from Pfizer/BioNTech, Moderna and Janssen Pharmaceuticals of Johnson&Johnson. As of December 28th, 2021, according to WHO, there are more than 300 COVID-19 vaccines in pre-clinical and clinical development. So, how did those three pull ahead and become the leaders in the r...
Enzymes as Drug Targets (An Intro) - Medicinal Chemistry 1.11
Просмотров 9 тыс.2 года назад
Enzymes are essential for life, and dysregulated or mutated enzymes could lead to diseases. Enzyme-targeting drugs make up about 47% of marketed small-molecule drugs. Besides how important the catalytic activity of enzyme is, another reason that they are frequently targeted for therapeutics is that they are relatively easy to target or they are more druggable compared to other biomolecules. Mos...
Conformational Selection Model vs. Induced Fit Model - Medicinal Chemistry 1.10
Просмотров 3,5 тыс.2 года назад
Both induced fit model and conformational selection model describe a flexible ligand-binding pocket. But the key difference between these two models is when the conformational changes happen. In induced fit model, the pocket conformational change happens after the ligand binding. In conformation selection model, the conformational change happens before the binding and the ligand selects which c...
What is the controversy over Aducanumab/Aduhelm for Alzheimer's?
Просмотров 1,8 тыс.2 года назад
In June 2021, the FDA approved Aducanumab/Aduhelm as the first new drug for Alzheimer’s disease in 18 years. It sparked controversies, surprises and even disappointment among scientific communities. Upon approval, three FDA advisers resigned due to the lack of evidence that the drug is effective. One month later, FDA Acting Commissioner Dr. Janet Woodcock requested an investigation to look into...
Proteins as Drug Targets: Microtubule Inhibitors - Medicinal Chemistry 1.9
Просмотров 3,6 тыс.2 года назад
Microtubule is an attractive target for anticancer drugs because of its important role in mitosis. In fact, it has been one of the most successful chemotherapeutic targets. Mitotic or microtubule inhibitors would disrupt microtubules and inhibit mitosis of cancer cells because cancer cells are able to grow and eventually spread through the body through non-stop mitosis. Cancer cells tend to div...
NEW COVID-19 antiviral Molnupiravir: mechanism of action, effectiveness and safety concerns
Просмотров 10 тыс.2 года назад
What is the new Covid-19 antiviral Molnupiravir? In November 2021, UK approved the first Covid antiviral drug that can be taken orally, called molnupiravir and branded as Lageviro. This could be a huge milestone in fighting against Covid because orally available antivirals are much more accessible and can be taken at home. When the coronavirus enters our body, it inserts its genetic information...
Quaternary Structure of Protein - Medicinal Chemistry 1.8
Просмотров 2,5 тыс.2 года назад
Quaternary Structure of Protein - Medicinal Chemistry 1.8
Tertiary Structure of Protein - Medicinal Chemistry 1.7
Просмотров 1,5 тыс.2 года назад
Tertiary Structure of Protein - Medicinal Chemistry 1.7
Beta Sheet, Protein Secondary Structure - Medicinal Chemistry 1.6
Просмотров 4,3 тыс.2 года назад
Beta Sheet, Protein Secondary Structure - Medicinal Chemistry 1.6
Alpha Helix, Protein Secondary Structure - Medicinal Chemistry 1.5
Просмотров 4,5 тыс.2 года назад
Alpha Helix, Protein Secondary Structure - Medicinal Chemistry 1.5
Amino Acids Classification and Protein Primary Structure - Medicinal Chemistry 1.4
Просмотров 1,9 тыс.2 года назад
Amino Acids Classification and Protein Primary Structure - Medicinal Chemistry 1.4
First Nobel Prize in Chemistry 1901 - Jacobus H. van't Hoff
Просмотров 1,9 тыс.2 года назад
First Nobel Prize in Chemistry 1901 - Jacobus H. van't Hoff
10 Types of Drug Discovery Scientists
Просмотров 9 тыс.2 года назад
10 Types of Drug Discovery Scientists
Lock-and-key, Induced Fit, Conformational Selection, and Protein Dynamics - Medicinal Chemistry 1.3
Просмотров 2,6 тыс.2 года назад
Lock-and-key, Induced Fit, Conformational Selection, and Protein Dynamics - Medicinal Chemistry 1.3
Drug Targets: DNA, RNA and Protein - Medicinal Chemistry 1.2
Просмотров 5 тыс.2 года назад
Drug Targets: DNA, RNA and Protein - Medicinal Chemistry 1.2
What Is a Drug, Therapeutic Index, Selective Toxicity - Medicinal Chemistry 1.1
Просмотров 3,3 тыс.2 года назад
What Is a Drug, Therapeutic Index, Selective Toxicity - Medicinal Chemistry 1.1
Can irreversible inhibitors side effects be permanent?
tghis pill gave a a boner that lasted 48 hours. Thank god i was in thailand
Even though this is 2 years old, it's very interesting, and should be a "special topic" in a molecular biology class (IMO). Good job explaining the science, as well as potential risks.
Simple and Short and actually what you titled in the Video! THANK YOU
Thank you for this valuable work 😊
Thank you! good illustrations
I liked the explanation very much it's great
Thank u
Can you please share the reference for the last picture shown in the video? (30% ...),
Is it possible to tell me what the difference between a pharmaceutical chemistry and medicinal chemistry?
There the same exact thing. “Pharmaceutical” and “medicinal” are used interchangeably.
Excellent
Where does formulation chemist fall?
1:45 compound/inhibitor= TS-ANALOG
0:50 smh modern beauty standards
Can you recommend me a book which covers this topic in detail
Thank you for posting this! Something I'm a little confused about: you stated around 1:04 that a peptide bond is formed via "a dehydrogenation or condensation reaction". Isn't dehydrogenation the removal of JUST hydrogen? So, it wouldn't actually be a dehydrogenation reaction in the case of a peptide bond forming?
The video is great. But speak louder..you voice comes out as a muffle
This is soo helpful, thank you soo much Daniel for going into the details without overcomplicating things. Keep up the excellent work
Why they are called beta
By the way generally only pharmacist do medicinal chemistry
Early day scientifics sometimes consisted of 1 person. A team is best, but its possible with less people. Thanks for this information.
I am currently in pharmacy school and I hope to continue in the field of medicinal chemistry,But in Iraq we only have a pharmaceutical chemistry program. The question is whether pharmaceutical chemistry and medicinal chemistry have the same focus in work and research.
There the same exact thing
Hello! Thank you for great video! I am 4th year undergraduate student, and i am choosing between bioinformatics and experimental biology now. Could you please answer do computational biologists/chemists in addition to data analysis, plan experiments and make hypotheses? That is, how much biology/chemistry are there in bioinformatics? Can computational scientist, for example, suggest some new experimental technology?
Thanks you sir your videos are helping me to get some knowledge about medicinal chemistry... 🎉❤
I need that drug
My Doctor forgot to give me this drug period AMEN.
Thank you for such clear informative videos.
This was extremely helpful! Thank you, good sir.
D stands for distribution. 🙂
my husband recovered within 3 days of beginning paxlovid but immediately began experiencing high blood pressure and despite high blood pressure meds within one month suffered a stroke. if I had know this I would have insisted he take one baby aspirin a day.
Perfect 👌🏻 ❤
id say both are likely and are not mutually exclusive, in fact id say that it is absurd to assume that selection can occur without the degree of variation (of one at least) still being capable of performing the necessary catalyses. Id also say that over time selection would move towards a lock and key level of fit. But ive been wrong before :) 10/10
how is this video so small this is such a good video man seriously
Hello, I am an Organic Chemistry post-graduate student, and even at this point understanding the drug discovery process can be chaotic. Even though I like Organic Chemistry I am very curious about other disciplines and I would like to get involved in other fields in the future. Your video provides great insights, thank you!
Thank you!
This made me break out on a neck rash. And it made me feel like I was in the fight of my life. After 3 days I had to discontinue.
This was really helpful :) I'm a new PhD student starting a project about targeting GPCR-mediated extracellular acid sensing by tumor cells and I'm just starting to learn why GPCRs are such common targets of drugs. In the future, maybe the exact GPCRs responsible for binding protons can be identified and targeting them can limit tumor cells from positively responding to the low acidity conditions they generate!
Great stuff man, currently doing my VCE Yr12 biology and I've watched many videos however this one explains everything very clearly others try to keep it simple or too complicated.
This video is so helpful for me, thank you so much.
Thank you for the information.
Last virus I was in ICU and step-down for 7 days. Recently got Covid...J and J primary and Moderna.booster....got Paxlovid ...was only sick for 3 days...minor temp of 99.1..... the metallic taste was terrible....tired with a slight headache......better than full blown Covid I say!
This is a miracle dose of pills. Started feeling better after first dose of 3 pills after suffering from fever for 2 days straight. Took 3 pills the evening I got the prescription, and I was finally able to sleep that night. Fever came down considerably. I didn't care about the after taste, I just needed relief from the pain and fever.
Pos
Sir I am doing bachelor degree in chemistry and want to be in pharmaceutical industry in future. I planed to go for masters in drug discovery but I am confused that in which field in the drug discovery I should go for?medicinal chemist , analytical chemist, computational chemist. Please guide me sir about it?
Decently explained🥰 sir please share your email address I have some queries which I want to discuss with you?
where would chemical biologists fall under or are they the same as medicinal chemists ?
I am an Analytical chemists and have always liked the computation in the pharmaceutical industry. we go we go.