Extracellular RNA Communication Consortium
Extracellular RNA Communication Consortium
  • Видео 78
  • Просмотров 52 206
Common Fund Data Ecosystem (CFDE) GTEx ERCC Virtual Workshop Sept 12, 2024
Workshop title: Biomarker discovery from extracellular (cell-free) RNA-seq and tissue of origin from GTEx RNA-seq profiles. The workshop describes how to download data from GTEx and ERCC data centers and conduct integrative analysis.
Просмотров: 193

Видео

Cellular Function of Y-RNA - Sandra Wolin
Просмотров 207Год назад
In lecture 2.3 of the Extracellular RNA Online Course, Sandra Wolin from the National Cancer Institute provides an overview of what is known about the role of Y-RNA inside the cell.
Case Study: Which exRNA carriers in plasma contain Y-RNA? - Esther Nolte-'t Hoen & Tom Driedonks
Просмотров 55Год назад
In this lecture from Week 4 of the Extracellular RNA Online Course, Esther Nolte-'t Hoen from Utrecht University and Tom Driedonks from University Medical Center Utrecht expand on their earlier introduction to extracellular Y-RNA, showing how to use different experimental methods to study Y-RNA carriers. Chapter Markers 01:17 Different RNA Carriers in Plasma 02:07 Why do we care? 02:51 Lecture ...
Extracellular Y-RNA - Esther Nolte-'t Hoen & Tom Driedonks
Просмотров 94Год назад
In this lecture from Week 2 of the Extracellular RNA Online Course, Esther Nolte-'t Hoen from Utrecht University and Tom Driedonks from University Medical Center Utrecht give a focused lecture on what is known about extracellular Y-RNA. Chapter Markers 00:12 Lecture Contents 00:37 Discovery of Extracellular Y-RNA 01:14 Discovery of Extracellular Y-RNA in EVs 02:07 Main Questions 03:07 Y-RNA in ...
PCR for Extracellular RNA - Julie Saugstad
Просмотров 82Год назад
In this lecture from Week 4 of the Extracellular RNA Online Course, Julie Saugstad from Oregon Health & Science University discusses methods for studying and quantitating extracellular RNAs via Polymerase Chain Reaction (PCR). Chapter Markers 00:22 DNA Biochemistry 01:24 The Polymerase Chain Reaction 02:49 Template DNA 03:54 Primers 05:11 DNA Polymerase 05:55 Specificity 06:47 DNA Polymerase Fi...
ERCC webinar July 2023: Jennifer Petersen & Joshua Zimmerberg
Просмотров 201Год назад
Jennifer Petersen from the National Institute of Neurological Disorders and Stroke (NINDS) and Joshua Zimmerberg from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) present their finding that some microvesicles themselves contain multivesicular bodies and secrete exosomes. The means of discovery was electron microscopy of endothelial cells preserved ...
ERCC webinar April 2023: Juan Pablo Tosar
Просмотров 148Год назад
Juan Pablo Tosar from the University of the Republic of Uruguay and Institute Montevideo discusses his group's latest work on extracellular transfer RNAs. The presentation was given as part of the Extracellular RNA Communication Consortium (ERCC) webinar series on April 13th, 2023.
ERCC Webinar: Edgar Gonzalez-Kozlova - Novel approaches to characterizing EVP transcriptomes
Просмотров 145Год назад
Edgar Gonzalez-Kozlova from the Precision Immunology Institute at the Icahn School of Medicine at Mt. Sinai discusses the problem of small unannotated RNA fragments in extracellular vesicle and particle samples, outlining different methods for mapping small RNA sequencing reads onto the genome. The presentation was given as part of the Extracellular RNA Communication Consortium (ERCC) webinar s...
ERCC Webinar: Guoping Li - tRNA-derived small RNAs (tDRs) in stress
Просмотров 2882 года назад
Guoping Li from the Cardiovascular Research Center at Mass General and Harvard Medical School discusses the expression of tRNA-derived small RNAs (tDRs) in different stress conditions. The presentation was given as part of the Extracellular RNA Communication Consortium (ERCC) webinar series on October 6th, 2022.
Medical Uses of mRNA-based Directed Gene Delivery
Просмотров 9212 года назад
In this lecture from Week 5 of the Extracellular RNA Online Course, A.C. Matin from Stanford University discusses the use of EVs for targeted delivery of mRNA to cancer cells. Gene-directed enzyme prodrug therapy (GDEPT) is a strategy to kill cancer cells by delivering to them an enzyme that activates a benign prodrug into a cell-killing drug. Dr. Matin's EXO-DEPT strategy delivers the mRNA cod...
Lipoprotein Transport of Extracellular RNA - Kasey Vickers
Просмотров 1912 года назад
In lecture 3.3 of the Extracellular RNA Online Course, Kasey Vickers of Vanderbilt University discusses lipoproteins and their transport of extracellular RNA in circulation. Angela Zivkovic of University of California Davis contributed to the development of the lecture. 00:00 Lipoprotein Transport of Extracellular RNA 00:13 Objectives 00:53 Two Flavors of Lipoproteins 01:58 Physico-chemical Pro...
What makes a good biomarker? - Ravi Shah
Просмотров 3942 года назад
In lecture 5.1 of the Extracellular RNA Online Course, Ravi Shah from Massachusetts General Hospital and Harvard Medical School discusses what makes a useful biomarker of disease, with particular attention paid to the new classes of exRNA and extracellular vesicle biomarkers. Venkatesh Murthy from University of Michigan Ann Arbor contributed to the development of the lecture. We acknowledge all...
Biogenesis and Intercellular Transfer of exRNA via Extracellular Vesicles - Alissa Weaver
Просмотров 6532 года назад
In this lecture from Week 3 of the Extracellular RNA Online Course, Alissa Weaver, Director of the Center for Extracellular Vesicle Research at Vanderbilt University, discusses biogenesis and intercellular transfer of exRNA via extracellular vesicles. Chapters 00:00 Biogenesis and Intercellular Transfer of exRNA via EVs 00:09 Extracellular RNA carried in Vesicles 01:43 Two Major Classes of EVs ...
ERCC Webinar: Sanjay Tyagi - Molecular beacons to visualize mRNA traffic and dynamics in live cells
Просмотров 2762 года назад
Sanjay Tyagi from the Rutgers New Jersey School of Medicine Public Health Research Institute discusses the molecular beacon technology he developed and its application to visualizing mRNA traffic and dynamics in live cells. The presentation was given as part of the Extracellular RNA Communication Consortium (ERCC) webinar series on June 2nd, 2022.
History of Extracellular Vesicle RNA - Xandra Breakefield
Просмотров 1,1 тыс.2 года назад
In lecture 1.2 of the Extracellular RNA Online Course, Xandra Breakefield from Massachusetts General Hospital discusses the history of research into exRNAs bound in extracellular vesicles. Chapters 00:00:00 History of EV RNA Research 00:00:39 Overview 00:01:46 First Came the EVs 00:04:11 EVs are Functional 00:04:53 Paths to Vesicle Biogenesis 00:05:45 Interaction with Target Cells 00:06:59 Vesi...
ERCC Webinar: Alissa Weaver - Biogenesis of RNA-containing EVs at ER membrane contact sites
Просмотров 4832 года назад
ERCC Webinar: Alissa Weaver - Biogenesis of RNA-containing EVs at ER membrane contact sites
ERCC Webinar: Dimitris Lagos - Non-coding RNA in COVID-19
Просмотров 812 года назад
ERCC Webinar: Dimitris Lagos - Non-coding RNA in COVID-19
ERCC Webinar: Ryan Flynn - Small RNAs modified with N-glycans on the surface of living cells
Просмотров 1,9 тыс.2 года назад
ERCC Webinar: Ryan Flynn - Small RNAs modified with N-glycans on the surface of living cells
ERCC Webinar: Michael Segel - Harnessing endogenous retroviral-like proteins for RNA delivery
Просмотров 3792 года назад
ERCC Webinar: Michael Segel - Harnessing endogenous retroviral-like proteins for RNA delivery
ERCC Webinar: Juan Pablo Tosar - DIE HARD: Non-vesicular exRNA metabolism
Просмотров 2013 года назад
ERCC Webinar: Juan Pablo Tosar - DIE HARD: Non-vesicular exRNA metabolism
ERCC Webinar: Steven Jay-Tackling challenges of extracellular vesicle-based therapeutic development
Просмотров 3943 года назад
ERCC Webinar: Steven Jay-Tackling challenges of extracellular vesicle-based therapeutic development
Nanomaterials and RNA engineering for mRNA therapeutics, genome editing, and cell therapy
Просмотров 4623 года назад
Nanomaterials and RNA engineering for mRNA therapeutics, genome editing, and cell therapy
Eric Van Nostrand - ENCORE: The ENCODE RNA regulatory element project
Просмотров 5063 года назад
Eric Van Nostrand - ENCORE: The ENCODE RNA regulatory element project
Brian White - The CIBERSORTx deconvolution algorithm
Просмотров 7 тыс.3 года назад
Brian White - The CIBERSORTx deconvolution algorithm
exRNAdata2021 - Formulating an exRNA Data Analysis Challenge
Просмотров 973 года назад
exRNAdata2021 - Formulating an exRNA Data Analysis Challenge
exRNAdata2021 - Discussion Panel / Question & Answer Session from Day 2
Просмотров 723 года назад
exRNAdata2021 - Discussion Panel / Question & Answer Session from Day 2
Bojan Losic - Small RNA clusters in circulating extracellular vesicles in liver and prostate cancer
Просмотров 2243 года назад
Bojan Losic - Small RNA clusters in circulating extracellular vesicles in liver and prostate cancer
Leonora Balaj - Discovery and validation of novel mRNA signatures in gliomas
Просмотров 1373 года назад
Leonora Balaj - Discovery and validation of novel mRNA signatures in gliomas
Emily LaPlante - A look at the exRNA Atlas from the RBP perspective
Просмотров 1103 года назад
Emily LaPlante - A look at the exRNA Atlas from the RBP perspective
Bogdan Mateescu - RNA binding proteins and exRNAs
Просмотров 2723 года назад
Bogdan Mateescu - RNA binding proteins and exRNAs

Комментарии

  • @rafaelandres9728
    @rafaelandres9728 Год назад

    'promosm' 😔

  • @System35191
    @System35191 Год назад

    Do you know which particle of these go throoough the blood brain barrier?

  • @abhisek175
    @abhisek175 Год назад

    Why is the video and audio not in sync? The slides moves ahead and the audio is lagging behind.

  • @tamrinimelda
    @tamrinimelda Год назад

    Tolong kepada DINKES atau DLH untuk menutup bagian atas saluran got yang berada di depan pesantren ekonomi darul uchwah, kedoya, jakarta barat #salamTAMRINgantenk

  • @SanjayTyagiNY
    @SanjayTyagiNY Год назад

    Great talk

  • @StochasticCockatoo
    @StochasticCockatoo Год назад

    was that referenced almeida the one who arranged the european brain conference?

  • @StochasticCockatoo
    @StochasticCockatoo Год назад

    If we can deliver intelligence genes into the brain.. (maybe it's possible and urgent - even eliezer says it's important for AI risk) => more resources

  • @StochasticCockatoo
    @StochasticCockatoo Год назад

    there's a chance this may be important for intelligence enhancement (which even now Eliezer says is urgent => more resources!)

  • @sebastianstewart6894
    @sebastianstewart6894 Год назад

    What is the difference between this and viruses?

  • @kipling1957
    @kipling1957 2 года назад

    “Ejaculate from a person who has given birth to children” what?

  • @tauras3108
    @tauras3108 2 года назад

    Just stop now . Messing around with genes and DNA is the highest folly and the consequences could be catastrophic for humanity.

    • @acmatin6211
      @acmatin6211 2 года назад

      Nature itself messes with genes - this is an attempt to right a wrong!

    • @CompBioQuest
      @CompBioQuest Год назад

      This comment makes no sense. Thanks to this technologies we, humans, are very close to eradicate many diseases and world hunger.

  • @sanriodovan9092
    @sanriodovan9092 2 года назад

    I'm very lucky to have met #drekpen who cured me from HIV and Tinnitus completely. Visit #drekpen

    • @acmatin6211
      @acmatin6211 2 года назад

      Great - Nature’s wrong put right! So happy for you.

  • @StochasticCockatoo
    @StochasticCockatoo 2 года назад

    17:58 is b est

  • @StochasticCockatoo
    @StochasticCockatoo 2 года назад

    why are exosomes so immune-tolerant?

  • @nadiaprasad3425
    @nadiaprasad3425 2 года назад

    This guy is so cool!

  • @SanjayTyagiNY
    @SanjayTyagiNY 2 года назад

    Great talk on very nice work - Sanjay Tyagi

  • @edwardidara2631
    @edwardidara2631 2 года назад

    Thank God I’m cured from Herpes virus after I used Dr Ozuka Herbal supplements, which he sent me after I contacted him for help.

  • @jaboris2536
    @jaboris2536 2 года назад

    Viruses are mistaken exosomes and viral spread has no replicable data to show

  • @lejlasvajger5600
    @lejlasvajger5600 3 года назад

    ❤️❤️❤️

  • @ezzovonachalm7534
    @ezzovonachalm7534 3 года назад

    This is not a very informative presentation.what interests people is, if the analysis e.g. of the RNA contained in such vescicles can reveal the presence of a determinate genetic disease or of determinated cancer cells, and if those markers appear long before the patient notices particular symptomes suspect of cancer origin.

    • @extracellularrnacommunicat5827
      @extracellularrnacommunicat5827 3 года назад

      You might want to take a look at these other webinars from the series. They address, for particular diseases, research to identify exRNA in vesicles that act as early biomarkers of disease. ruclips.net/video/mJJKTp5NEbQ/видео.html ruclips.net/video/tmkEB8YBHBQ/видео.html ruclips.net/video/EA1gV9iTQto/видео.html ruclips.net/video/-VJj1tkJOsE/видео.html

  • @garvintimmann
    @garvintimmann 3 года назад

    frozen will last up to 6 months

  • @thomaselster8629
    @thomaselster8629 3 года назад

    Nice upload, keep up the good work. Have you heard of Promosm?! I’ve been using it on my main channel and now my videos are ranking much better!!

  • @angeldevilleheavenly4009
    @angeldevilleheavenly4009 4 года назад

    So rh- has no antugens on tge red blood cell, si no msn made virus can attach/attack any rh-. But alk rh+ have antigens on rbc, so a man made virus can attach/attack. This is know as genocide depopulation of the rh+ bloodgroups.

  • @InfiniteUniverse88
    @InfiniteUniverse88 4 года назад

    25% of cancers are caused by Kirsten Sarcoma Virus, which is responsible for KRAS mutations. Therefore, creating a vaccine for KSV is of utmost importance.

  • @InfiniteUniverse88
    @InfiniteUniverse88 4 года назад

    I'm going to have to look up some of the proteins in this video on the pdb, and other protein databases when I get the chance. I'm mostly looking for hydrophobic interactions for a protein prediction program I'm working on.

  • @JohnDoe-dx7bu
    @JohnDoe-dx7bu 4 года назад

    Is covid-19 one in the same as an exosome? Asking for a friend.

    • @nikhillondhe369
      @nikhillondhe369 4 года назад

      Is it??

    • @extracellularrnacommunicat5827
      @extracellularrnacommunicat5827 4 года назад

      SARS-CoV-2 and other enveloped viruses are in fact extracellular vesicles. They borrow the host cell's machinery to wrap themselves in a lipid membrane, which protects them in circulation and hides them to an extent from the immune system.

    • @extracellularrnacommunicat5827
      @extracellularrnacommunicat5827 4 года назад

      It does have proteins in its surface, though, which interact with proteins on the surface of target cells and allow it to get in. Fighting off Covid-19 involves the immune system recognizing those surface proteins and making antibodies to block them. And then the immune system can kill the viruses tagged with those antibodies.

    • @extracellularrnacommunicat5827
      @extracellularrnacommunicat5827 4 года назад

      (SARS-CoV-2 is the virus and Covid-19 is the disease it causes, like HIV causes AIDS.)

    • @sebastian7052
      @sebastian7052 4 года назад

      @@extracellularrnacommunicat5827 That sounds interesting. Can you do an informative video to that specific topic please?

  • @yougotmefeelinglikeapsycho6046
    @yougotmefeelinglikeapsycho6046 5 лет назад

    I feel so proud of him. He's my cousin

  • @feliskeviticus
    @feliskeviticus 5 лет назад

    What if the vesicles are shedding the cell? Could it be the other way around? I think its worth considering. Awesome presentation--Thank You!

  • @99harshini
    @99harshini 6 лет назад

    Simply brilliant!

  • @dennisfink2619
    @dennisfink2619 6 лет назад

    Very interesting!

  • @ionicguy4919
    @ionicguy4919 8 лет назад

    Emily, first, thank you for a great talk. I'm writing my bachelor's on extracellular RNA as a biomarker for disease. It's going to be a review. Do you have any suggestions on an interesting area that I could write about in this topic?