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Pharmechanics
Добавлен 5 ноя 2018
The Operational Model Explained Part 2
Interested in GPCR signaling pharmacology? Check out this video, which explains why the data look the way they do in our GPCR signaling assays.
This is Part 2 of a series explaining the operational model of agonism, which beautifully describes why our GPCR signaling data looks the way it does (pubmed.ncbi.nlm.nih.gov/6141562/). See ruclips.net/video/EQS0_pQ61PQ/видео.html for Part 1, which introduced the model in simple terms that can be understood by drug discovery scientists and receptor researchers.
In Part 2 here we take a deeper dive into operational model. The goal here is to provide a foundation for using the operational model to explore and analyze our data, and to engage with the f...
This is Part 2 of a series explaining the operational model of agonism, which beautifully describes why our GPCR signaling data looks the way it does (pubmed.ncbi.nlm.nih.gov/6141562/). See ruclips.net/video/EQS0_pQ61PQ/видео.html for Part 1, which introduced the model in simple terms that can be understood by drug discovery scientists and receptor researchers.
In Part 2 here we take a deeper dive into operational model. The goal here is to provide a foundation for using the operational model to explore and analyze our data, and to engage with the f...
Просмотров: 151
Видео
The Operational Model Explained Part 1
Просмотров 40512 часов назад
Interested in GPCR signaling pharmacology? Check out this video, which explains why the data look the way they do in our GPCR signaling assays. Signaling data is beautifully explained by the operational model of agonism (pubmed.ncbi.nlm.nih.gov/6141562/). However this model was presented 40 years ago, before we understood how GPCR signaling works, and so is written in a form that is difficult f...
Curve fitting workshop for analyzing GPCR signaling kinetics in GraphPad Prism
Просмотров 262Месяц назад
Measuring GPCR signaling over time tells us about mechanisms of signal transduction, and quantifies the duration of signaling in the development of agonist therapeutics. In this video we describe how to analyze time course data by curve fitting in GraphPad Prism using a free plugin of custom equations. For file downloads and instructions see: drive.google.com/drive/folders/1F5Qlyi30a3VNu9ZzCTKu...
The Problems of Applying Classical Pharmacology to Modern Drug Discovery
Просмотров 2,6 тыс.Год назад
Pharmacology data analysis was developed a century ago and is used by default in modern drug discovery to quantify ligand potency for drug targets. This video describes the problems that can result when largely forgotten assumptions of classical pharmacology are infringed, by modern assay technology and very high affinity drugs and drug candidates. These assumptions are: 1) The target concentra...
Kinetics of Drug-Target Binding
Просмотров 3,8 тыс.3 года назад
Here we present a deep dive on drug-target binding kinetics in drug discovery. Topics include: Binding kinetics and pharmacodynamics In vitro potency distortion by slow dissociation Methods for measuring binding kinetics Real-world case study on binding kinetics in drug discovery For more information please contact sam.hoare@pharmechanics.com or visit www.pharmechanics.com Slides available at: ...
Kinase inhibitor residence time analysis
Просмотров 924 года назад
Kinase inhibitor residence time analysis in GraphPad Prism: A new template from Pharmechanics. To get started, please watch and listen to the video. Then download the template and instructions from: www.graphpad.com/support/faqid/2102/
Biased agonism made simple using signaling kinetics
Просмотров 4625 лет назад
A Pharmechanics and Montana Molecular collaboration. www.pharmechanics.com www.montanamolecular.com Video promo for Society for Laboratory Automation and Screening meeting 2019.
Kinetic efficacy - a new way to measure drug effect
Просмотров 5145 лет назад
It turns out analyzing time course data provides more bang for your pharmacology buck - this video shows why. Biosensor and calcium data can be analyzed this way, and we can help you do this. There may be data you've already generated that we can apply this to. For more information, check out www.pharmechanics.com/ Contact me at sam.hoare@pharmechanics.com Check out the Dropbox "Kinetic efficac...