MRC IEU at University of Bristol
MRC IEU at University of Bristol
  • Видео 120
  • Просмотров 40 391
IEU Seminar: Siana Jones
Title: Physical activity in childhood and adolescence to promote cardiovascular health in adulthood
Abstract: Physical activity (PA), particularly exercise training, is beneficial for cardiovascular (CV) health but the long-term benefits of undertaking PA throughout childhood and adolescence on adult CV health are poorly understood. In this presentation I aim to describe the rationale, methods and pilot analyses from a recently submitted research proposal that incudes analyses using longitudinal PA data and CV health outcomes measured in G1 ALSPAC participants.
Biography: I am a Senior Post-doctoral Research Fellow at UCL in the MRC Unit of Lifelong Health and Ageing. I have a background in...
Просмотров: 11

Видео

IEU seminar: Mary Schubauer-Berigan
Просмотров 10День назад
Title: Evidence synthesis and integration for cancer hazard identification: the approach of the IARC Monographs programme Abstract: For over 50 years, the Monographs programme of the International Agency for Research on Cancer (IARC) has evaluated the carcinogenic hazard posed by more than 1000 agents, bringing together international expert working groups in cancer epidemiology, animal cancer b...
IEU Seminar: Andrew Mumford and Daniel Greene
Просмотров 32День назад
Title: Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders. Abstract: The genetic aetiologies of more than half of rare diseases remain unknown. Standardized genome sequencing and phenotyping of large patient cohorts provide an opportunity for discovering the unknown etiologies. Here we demonstrate our computational approach to rare disea...
Triangulation of evidence in aetiological epidemiology: principles, prospects, limitations
Просмотров 8914 дней назад
Prof George Davey Smith spoke on "Triangulation of evidence in aetiological epidemiology: principles, prospects, limitations". He was giving the Sharwaree Gokhale Memorial Lecture at the Centre for Brain Research (CBR) Indian Institute of Science, Bangalore, India on 5th December 2023.
Fundamentals of Mendelian randomization in 2024
Просмотров 2153 месяца назад
Professor George Davey Smith spoke at NTNU, Trondheim on 17th June 2024.
Everywhere and nowhere: will we ever identify the missing environmental causes of disease?
Просмотров 5423 месяца назад
Professor George Davey Smith spoke at NTNU, Trondheim on 17th June 2024.
Introduction to Molecular drivers & predictors of pregnancy complications & future health programme
Просмотров 975 месяцев назад
Deborah Lawlor and Caroline Borges give an introduction to the Molecular drivers & predictors of pregnancy complications & future health programme at the MRC Integrative Epidemiology Unit, University of Bristol. This programme undertakes translational research aimed at improving antenatal and postnatal care and inequalities in this care. For more information see: www.bristol.ac.uk/integrative-e...
Mendelian Randomization - what it was, what it is, and what it should become.
Просмотров 6125 месяцев назад
Recorded by UCL London on 25th April 2024.
Mendel’s randomness: from allowing complex life to facilitating causal inference
Просмотров 1366 месяцев назад
A talk by George Davey Smith at UCL on 13 February.
IEU Seminar: Vittal Katikireddi
Просмотров 3487 месяцев назад
Title: Developing evidence to address the economic determinants of health inequalities: Attempting to move from description to a policy response Abstract: The economic determinants of health are potentially of fundamental importance for population health and health inequalities. At the individual level, experiences of poverty, unemployment and financial insecurity have all been linked to poor h...
IEU Seminar: Matt Tudball
Просмотров 5248 месяцев назад
Title: Genetics-based drug discovery: Some stories from the frontline. Brief abstract: Human genetics has become an increasingly popular means of identifying modifiable therapeutic targets for disease. For the last 16 months, I have been working at a start-up that partners with biotech, venture capital and pharma companies to interrogate their drug candidates and identify new ones using human g...
ICEP research into cancer progression and novel treatments
Просмотров 4710 месяцев назад
Research in the Integrative Cancer Epidemiology Programme (bristol.ac.uk/icep) falls into six themes. In this video, Philip Haycock of University of Bristol discusses the theme of cancer progression and novel treatments. This theme considers the most promising molecular targets for new and repurposed chemoprevention and therapeutic drugs.
IEU Invited Lecture: Michael Inouye
Просмотров 24811 месяцев назад
Title: Systems genomics for population health: From risk prediction to aetiology Brief abstract: Over the past 15 years, the generation of high-dimensional omics data in population research has become common place. In this talk, I’ll cover challenges and recent advances in using genomics, metabolomics, proteomics and other modalities for the purposes of disease risk prediction and understanding...
ICEP research on smoking cessation
Просмотров 4211 месяцев назад
Research in the Integrative Cancer Epidemiology Programme (bristol.ac.uk/icep) falls into six themes. In this video, Jasmine Khouja of University of Bristol discusses the theme of smoking cessation. This theme looks at the causal effects of nicotine (including in e-cigarettes) on cancer risk and outcomes.
ICEP research into somatic genomics
Просмотров 6711 месяцев назад
Research in the Integrative Cancer Epidemiology Programme (bristol.ac.uk/icep) falls into six themes. In this video, Amy Francis of University of Bristol discusses the theme of somatic genomics. This theme looks at how exogeneous and endogenous factors influence the cancer-causing molecular aberrations that occur in body cells.
ICEP research into physical activity and sleep
Просмотров 15511 месяцев назад
ICEP research into physical activity and sleep
ICEP research on systemic responses
Просмотров 8111 месяцев назад
ICEP research on systemic responses
Noodles, No Nulls and Numb Skulls: Threats to the future of Mendelian Randomization - G. Davey Smith
Просмотров 2,9 тыс.11 месяцев назад
Noodles, No Nulls and Numb Skulls: Threats to the future of Mendelian Randomization - G. Davey Smith
Taking the "neurodevelopmental" part of "neurodevelopmental disorders" - Kevin Mitchell
Просмотров 56311 месяцев назад
Taking the "neurodevelopmental" part of "neurodevelopmental disorders" - Kevin Mitchell
From evolution at synonymous sites to improve gene therapy and diagnostics by Laurence Hurst
Просмотров 15011 месяцев назад
From evolution at synonymous sites to improve gene therapy and diagnostics by Laurence Hurst
ICEP research into metabolic health
Просмотров 53Год назад
ICEP research into metabolic health
George Davey Smith
Просмотров 372Год назад
George Davey Smith
IEU Seminar: David Ray
Просмотров 366Год назад
IEU Seminar: David Ray
IEU seminar: Hiroki Ueda
Просмотров 411Год назад
IEU seminar: Hiroki Ueda
Using Mendelian Randomization to model the causal effect of cancer on health economic outcomes
Просмотров 2,9 тыс.Год назад
Using Mendelian Randomization to model the causal effect of cancer on health economic outcomes
The changing paradigm in the pharmacological treatment of elevated blood pressure
Просмотров 176Год назад
The changing paradigm in the pharmacological treatment of elevated blood pressure
Investigating the Development Origins of Health and Disease Using Statistical Genetics Methods
Просмотров 211Год назад
Investigating the Development Origins of Health and Disease Using Statistical Genetics Methods
Trying to be a more useful epidemiologist: From heart disease to child maltreatment
Просмотров 154Год назад
Trying to be a more useful epidemiologist: From heart disease to child maltreatment
Disputed inheritance: The battle over Mendel and the future of biology - Professor Gregory Radick
Просмотров 628Год назад
Disputed inheritance: The battle over Mendel and the future of biology - Professor Gregory Radick
Integrative Cancer Epidemiology Programme (ICEP) Lab Tour
Просмотров 397Год назад
Integrative Cancer Epidemiology Programme (ICEP) Lab Tour

Комментарии

  • @bpath60
    @bpath60 5 месяцев назад

    Thank you

  • @yiminzhao330
    @yiminzhao330 5 месяцев назад

    nice talk!

  • @InquilineKea
    @InquilineKea 7 месяцев назад

    What does residual vs ranked mean

  • @InquilineKea
    @InquilineKea 7 месяцев назад

    Can PRS scores be used for MR

  • @InquilineKea
    @InquilineKea 7 месяцев назад

    Why are genetic interventions more potent than pharmaceutical for cholesterol and hcy risk?

  • @MesutErzurumluoglu
    @MesutErzurumluoglu 8 месяцев назад

    A great talk as always!

  • @santiagocastillo9391
    @santiagocastillo9391 8 месяцев назад

    BRILLANT AND POWERFUL..

  • @maskaliki
    @maskaliki Год назад

    Once you learn Mendelian randomization, all the hottest chicks in the world are yours!

  • @Orteaz
    @Orteaz Год назад

    I’m worried about my baby developing autism because of anti depressants. To me it sounds like a no brainier. You shouldn’t be messing with the cerebral cortex of a developing baby. But this chick stated she was focusing on the miscarriage side of the side effects. Does anyone know or can recommend another talk that would have 30 yrs worth of evidence to help me out?? Thanx in advance

  • @arneywillett4198
    @arneywillett4198 Год назад

    😳 *Promo sm*

  • @poldertalk
    @poldertalk Год назад

    Before Focke, in 1881, Mendel’s pea paper was cited four times (in 15 years since its publication); after Focke, not a single time. The so-called references are just catalog listings and mainly concern the hawkweed paper. De Vries’ reprint is no evidence for the “circulation of the 40 reprints”. Pea breeders like Rimpau and Giltay were unaware of Mendel’s work. Mendel’s contemporaries Wichura, Nägeli, and Caspary were cited many times. My conclusion: yes, Mendel’s work was neglected.

  • @poldertalk
    @poldertalk Год назад

    Mendel's work on peas was obscure and misunderstood before 1900. Most references were to his hawkweed hybrids or appeared in catalogs. Schmalhausen (1874) only found Mendel's pea paper when he already had his thesis at the printer and added an endnote. Focke (1882) also did not find Mendel until his book was almost finished. This shows that Mendel's pea work was little known. Schmalhausen wrote in Russian and Blomberg (1872) in Swedish, both internationally not widely spoken languages. Their publications were not rediscovered until well after 1900 and had no impact at their time. Hoffmann (1869) and Focke understood little of Mendel's pea paper. Four "real" references in almost 35 years is not a lot.

  • @georgesdelatour
    @georgesdelatour Год назад

    Rutherford notes that the great early opponent of eugenic sterilisation was G.K. Chesterton, but he doesn’t want to connect it too directly to Chesterton’s non-progressive, Catholic sanctity-of-life views; the same views which cause Catholics to oppose abortion. Rutherford supports abortion-on-demand. Yet today, the world’s single most extensive and successful eugenic program is the abortion of foetuses who test positive for Down’s Syndrome. In Europe, 92% of pregnant women who test positive choose to abort. High screening rates in Denmark and Iceland have resulted in there now being almost no one with Down’s Syndrome in either country.

  • @landinnes5925
    @landinnes5925 Год назад

    🌹 "promo sm"

  • @phaseholographicimaging5648
    @phaseholographicimaging5648 Год назад

    How exciting to see your HoloMonitor M4 live cell analysis system in action 😊 Greetings from your PHI team

  • @benitoteehankee3014
    @benitoteehankee3014 Год назад

    Very insightful and incisive. These are long overdue needed reforms in statistical practice.

  • @islamsalah4314
    @islamsalah4314 Год назад

    Wonderful

  • @SubAnima
    @SubAnima 2 года назад

    Great talk!

  • @whatislifebro
    @whatislifebro 2 года назад

    man i thought we were better than this, everyday i see the decay and devolution of humans to becoming controlled sheep slaves and incels, repeating garbage just like this. Question everything. Especially if theres a women talking about testosterone, and she is wrong, completely wrong. WE NEED STRONG MEN FOR FUCKS SAKE.

  • @Pynss
    @Pynss 2 года назад

    clicked off when i saw it was a WOMAN talking about testosterone and success

  • @APHS-B
    @APHS-B 2 года назад

    Yes, but we're just not that far back in human evolution. Phenotypic characteristics have been augmented by also behavioral observable characteristics, and performance observable characteristics, akin to human realm, that justify or refute the first. We do not need to re-discover anthropology, or reduce it to zoologia specialis, but naturally advance from that stand to anthropo-sociological natural selection parameters. If, then, that is already done, why discuss a subject leading to inferior, discriminatory, geno-puristic approaches?

  • @ducaalea1918
    @ducaalea1918 2 года назад

    It seems like she has an agenda against the theory that correlates testosterone to let's say successes. She is also complicating the matter by throwing the ' born with T Vs day circulating T." It doesn't matter to me were the T comes from. There is no doubt that T level and successes in men is correlated. It maybe bit exaggerated but there is a correlation. Instead of dismissing the link, the focus should be why certain men suffer from low T and how to remedy this. In the modern 'science' there is a lot of energy in dismissing certain realities to somehow ' comfort' those who lack these said attributes. I never used T enhancements and not a gung-ho about it, but denying there is a link between T level's in men and successes in sports, leadership and other avenues of life is a total rubbish!

  • @philipscott6256
    @philipscott6256 2 года назад

    𝖕𝖗𝖔𝖒𝖔𝖘𝖒 🔥

  • @ash.r9k
    @ash.r9k 2 года назад

    Personal success ≠ success on paper

  • @jack-wu4pd
    @jack-wu4pd 2 года назад

    so touching for an excellent video

  • @nancecunning6608
    @nancecunning6608 3 года назад

    Here is a link to the second half that he mentions: Sander Greenland: Advancing Statistics Reform, Part II mediaserver.unige.ch/play/151325 given at the University of Geneva Global Studies Institute