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Laboratory and Analytics New technologies in analytics, automation and big data analysis are revolutionising research and laboratories are changing faster than ever before. The lab of the future is modular, highly automated and can work with tiny sample quantities down to the single cell. Digital lab twins, machine learning and artificial intelligence enable the evaluation of huge amounts of data. Fields of application are, for example, modelling and simulation and new approaches to experimental design. The interaction of digitalisation, miniaturization and automation is fundamentally changing workflows and thus also how researchers in biotechnology and life sciences work. What role will robots and artificial intelligence play in the laboratory of the future, and where will human creativity and expertise come into play? Unlike the conventional measurement method of total cell density, where only the transmitted light is measured, Hamilton has taken the measurement technology to the next level and combined the advantages of transmission and reflection measurement into its Dencytee Arc sensor. By upgrading to two detectors, higher measurement resolution can be achieved. This results in higher reliability that can be used in both low and high-cell concentrations. The perfect linearity over the entire measuring range from 0 to 200 g/l and accuracy of ±1 % allows almost complete process monitoring and the establishment of process control, both in real time. “Until now, over 85 % of customers have measured cell density offline,” explains Katharina Dahlmann, product manager Cell Density. “This means a lot of laboratory work, high contamination risk, and inconsistent data quality due to handling errors and/or different operators. As there was no satisfactory alternative so far, users accepted these limitations,” she says. As a result, optimizing the process and process control previously required a lot of time and a precise understanding of the process. In a 24-hour fermentation, for example, 30 samples, including night samples, are taken over the entire process. Regular process monitoring should ensure that the induction point is not missed, but the process is very labor-intensive for laboratory personnel. In addition, long working days, as well as shift changes, can influence the results. The outcome is fluctuations in product yield and quality because the process cannot be controlled. All these challenges are now a thing of the past, thanks to the Dencytee Arc Sensor. The use of the probes reduces the number of offline samples, saving both time and money. The industry is ready for a new level of process control. Dencytee Arc takes advantage of Hamilton‘s Arc Intelligent sensor technology. Arc products offer direct communication with the process control system using common standards, such as Modbus digital protocol and 4-20-mA output signals and further more coming soon. The sensor not only sends a compensated measured value for controlling processes. It also offers a wide range of diagnostic functions, which are recorded automatically and in compliance with GMP. The total cell density (TCD) can thus be determined quickly and accurately and used for control and documentation.

Fossil free Production The chemical industry is more dependent on fossil fuels and raw materials than almost any other sector and the shortages here are likely to become even more acute as a result of the Ukraine war. That will further increase the pressure to decarbonize the chemical industry. Fossil-free production is an important and ambitious goal for reducing greenhouse gas emissions in the process industry and a promising way to become largely independent of fossil raw materials. Electrification, the use of alternative carbon sources such as CO2 or biogas, and the establishment of a circular economy remain major challenges on the process industries’’ climate agenda. Gas shortage! Energy crisis! Hardly a day goes by without such headlines. In view of current developments, the transformation of the process industry has gained enormous momentum. Doing without fossil fuels and raw materials is one of the most important goals here and a decisive milestone on the path to greater sustainability. But achieving this goal is easier said than done. What are the challenges to be overcome? What is the role of low-emission energy sources, the sustainability of raw materials and their recycling, as in the case of “circular carbon”? Where will the resources and raw materials of the future come from? And what is already available today? Separation Technology For Sustainable Production and Circularity Sulzer Chemtech is showcasing its cutting-edge processing solutions for chemical engineering, environmental protection and bio-based production at ACHEMA 2022. Attendees will be able to interact with the company’s leading experts and explore the separation and mixing technologies that can help businesses drive efficiency, sustainability and competitiveness, the company says. As a premier processing technology provider, Sulzer Chemtech will showcase its process plants and mass transfer solutions, placing a particular focus on sustainable production and circular strategies. During the event, the company’s specialists will hold a technical presentation on current challenges in plastic recycling and upcycling, as well as how innovative purification technologies are helping to address these and support plastic circularity. In particular, the presenters will showcase how Sulzer Chemtech’s innovative separation technologies can be used to develop ground-breaking chemical recycling facilities to process a wide range of polymers, including textiles. Sulzer Chemtech will also display its comprehensive mass transfer portfolio, process technology solutions, technology Sulzer Chemtech key process technologies Source: Sulzer Chemtech licensing and engineering capabilities at its stand. This will feature a virtual reality (VR) area, where visitors will be able to explore full-scale photorealistic reproductions of realworld processing and manufacturing facilities that leverage Sulzer Chemtech’s equipment. Users will be able to learn how plants can maximize throughput, product quality and energy efficiency, driving their productivity and sustainability. Anyone interested in learning more about Sulzer Chemtech’s offerings will also be able to discuss how to advance their operations and optimize their carbon footprint with leading experts available at the Sulzer stand throughout the event. Decentralized Production of Pure Oxygen Fraunhofer IKTS is one of the leading research institutions in the field of separation techniques using ceramic materials. In the area of O2 separation from air using mixed ionic-electronic conducting ceramic membranes, IKTS is the only supplier of commercially available membrane modules and pilot plants with technically relevant capacities. The device concept and the patented process management are aimed at minimum operating costs and a long service-life. The ceramic membranes are based on readily available raw materials. By using thin-walled membranes, the required material quantities have already been minimized and the oxygen output increased. The manufacturing process used is extrusion, which has a high potential for further cost reduction for large quantities. Any residual material resulting from the production process is completely recycled. The membranes incorporated tolerate high heating and cooling rates or thermal stresses, so that membrane systems can be implemented with short startup times. If required, stand-by operation and a variation of oxygen output of approx. 10 to 200 % compared to normal operation is possible. While established processes require all energy as electricity, MIEC membranes can be heated by burning of gas or by waste heat from high-temperature processes. The electricity requirement is then only 40 % of a large industrial air separation plant. In addition, there are further significant operating cost savings as the gas price is often only a quarter of the electricity price. Another advantage is the reduction of CO2 emissions. Conventional electricity production generates significantly more CO2 per kWh than gas combustion. Bucher Unipektin is acquiring 100 % of the German vacuum drying system supplier Merk Process GmbH. With the acquisition, Bucher Unipektin further strengthens its vacuumand freeze-drying capabilities. Merk Process, founded in 1994 by Dieter Merk, is privately owned and located in Laufenburg (Germany). The company supplies vacuum drying systems for the food, pharmaceutical and chemical industries and generated net sales of EUR 4 million in 2020. Its expertise is based on many years of practical experience in plant construction combined with efficient, innovative engineering skills, the company says. After the acquisition of Merk Process, Bucher Unipektin is in a position to supply a broader range of innovative and sound drying technologies and to provide an enhanced customer service offering to the vacuum and freeze drying customers of the two companies on a global basis, Bucher says. Following the transaction, the drying activities of both companies will be concentrated at Merk Process’ site in Laufenburg (Germany). Dieter Merk will actively contribute and assist the combining of the two companies’ technologies and knowhow as a consultant in the next years. Bucher Unipektin, a Swissbased business unit of Bucher Industries AG, is a globally leading manufacturer of plants and components for juice and beer production, as well as vacuum and freeze drying for the food industry. The business unit operates globally, with production sites in Switzerland, Spain and China supported by a global distribution network and its own sales and service organizations in Poland, Ukraine, Russia, New Zealand and Mexico.