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Biochemistry for Health Sciences
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Добавлен 8 ноя 2022
This channel is for healthcare students and professionals to learn and apply medically relevant biochemistry.
6.6 Isozymes
In this video, we explain what are isozymes and how they help the body regulate metabolism. Lactate dehydrogenase and hexokinase isozymes are used to explain the differences and similarities between isozymes and why different isozymes work better in different tissue environments, and why a certain isozyme may be more suited for the organ's function (example , why glucokinase is better for liver function than other HK isozymes). Clinical applications of isozymes is discussed next using examples of LDH and creatine kinase (CK) for myocardial infarction, phosphodiesterase for treatment of erectile dysfunction by the drug Viagra, cytochrome P450 isozymes for drug metabolism, and importance of...
Просмотров: 8
Видео
6.5 Zymogens
Просмотров 4День назад
This video explains the nature of zymogens such as trypsinogen, chymotrypsinogen and other pancreatic proteases, pepsinogen, several blood clotting proteins and complements. The activation of chymotrypsinogen into active chymotrypsin is discussed showing the steps involved in this process. Zymogen formation for powerful proteolytic enzymes is necessary so that the active enzyme is active only a...
6.4 Regulation of metabolism: Covalent modification
Просмотров 2321 день назад
Previous videos discussed regulation of metabolism (enzymes) by sequestering enzymes in specific compartments, availability of cofactors and allosteric regulation. This video discusses regulation of enzymes by covalent modification. The basic concept is explained with a focus on phosphorylation. Regulation of glycogen metabolism by insulin is used as an example to show how covalent modification...
6.3 Allosteric Regulation
Просмотров 1221 день назад
This video discusses the basic concept of allosteric regulation of enzymes in order to regulate metabolism. Enzymes, especially allosteric enzymes, are not only designed to catalyze reactions in metabolism, but also have properties that enable their regulation by binding of modulator chemicals, which could be activators (increasing enzyme activity) or inhibitors (decreasing enzyme activity). Th...
6.2 Regulation of Metabolism: Availability of Cofactors
Просмотров 22Месяц назад
In the previous video, we discussed how metabolism can be regulated by sequestering enzymes within specific compartments. In this video, we discuss how the availability of cofactors affect the rate of a metabolic pathway. We discuss two examples of this concept. The first is the inhibitory effect of NADH on the electron transport chain, TCA, PDH and glycolysis when a cell is in a high energy st...
6.1 Regulation of Metabolism: Sequestering enzymes within compartments
Просмотров 12Месяц назад
Metabolism can be regulated by several different strategies including controlling the amount of blood flow to a tissue and controlling the function or amount of transport proteins and/or enzymes involved in a metabolic pathway. In this video, we discuss how metabolism is regulated by sequestering enzymes within specific compartments such as cytoplasm, mitochondria, endoplasmic reticulum and per...
6.0 How is metabolism regulated?
Просмотров 58Месяц назад
In the previous section 5.0-5.30, we discussed important concepts relating to human metabolism. In this section 6.0 onwards, we shall discuss various ways by which metabolism is regulated in the body. This video provides an overview of the various strategies that the body utilizes in regulating metabolism.
5.30 Summary of human metabolism
Просмотров 162 месяца назад
The last thirty or so videos from 5.0 to 5.29 discussed various aspects of human metabolism. Understanding and applying metabolism rather than memorizing metabolism is important for the healthcare professional. This video summarizes the most important points on human metabolism and emphasizes the importance of maintaining blood glucose concentration above 40-50 mg/dL in order to supply sufficie...
5.29 Understand not memorize metabolism: Amino acids for Gluconeogenesis
Просмотров 532 месяца назад
One of the major sources of carbon skeletons (building blocks) for gluconeogenesis are amino acids, predominantly from skeletal muscles, where proteins are abundant. This video discusses how skeletal muscles makes and sends their amino acids from protein breakdown mainly as alanine and glutamine to the gluconeogenesis organs (liver, kidneys and small intestine). We next discuss how the gluconeo...
5.28 Understand not memorize metabolism: Ubiquitin Proteasome System and Autophagy
Просмотров 403 месяца назад
This video discusses how proteins in the muscle are degraded into amino acids during starvation in order to provide more building blocks for gluconeogenesis. The two systems discussed are the ubiquitin proteasome system (UPS) and the lysosomal autophagic pathways (macroautophagy, chaperone-mediated autophagy and microautophagy). The components of each system as well as the steps involved in bre...
5,27 Understand not memorize metabolism: Metabolism during starvation
Просмотров 553 месяца назад
In this video, we shall answer the question: What happens if you do not eat for several days after a meal? We discuss the key metabolic events that occur as we progress from the post-prandial state to early starvation and then enter the proteolysis stage of late starvation and eventually into the protein conservation phase of late starvation. We shall see how blood glucose is maintained by diet...
5.26 Understand not memorize metabolism: Gluconeogenesis
Просмотров 734 месяца назад
What is the gluconeogenesis pathway that is carried out by the liver, kidneys and small intestine during the starvation state? Why is this pathway important for our survival? Gluconeogenesis requires four special enzymes as well as building blocks, energy (ATP and GTP) and reducing agent (NADH). What are the building blocks for this synthesis (anabolic) pathway and where does the energy and red...
5.25 Understand not memorize metabolism: Early starvation: FA breakdown in peroxisomes
Просмотров 304 месяца назад
This video discusses how various fatty acids are broken down in peroxisomes. We discuss alpha-oxidation of branched chain fatty acids such as phytol and phytanic acid into pristanic acid. The beta-oxidation of pristanic acid, together with very long chain fatty acids, long chain dicarboxylic fatty acids (formed from omega-oxidation) and bile acid intermediates are then discussed, showing the pr...
5.24 Understand not memorize metabolism: Early Starvation: Fatty acid breakdown 2
Просмотров 474 месяца назад
In this video, we discuss beta-oxidation of monounsaturated and polyunsaturated fatty acids. The key steps involved in another type of oxidation, known as omega-oxidation, are also discussed. Why do we need omega-oxidation when we have beta-oxidation? The importance of omega-oxidation is discussed, including providing an alternate pathway if beta-oxidation is blocked, providing water barrier fo...
5 23 Understand not memorize metabolism: Early starvation: Fatty acid breakdown
Просмотров 515 месяцев назад
In a previous video, we discussed the importance of liver glycogen breakdown by glycogenolysis to maintain our blood glucose so that RBCs and brain cells have enough glucose for their survival, during early starvation. At the beginning of early starvation, liver glycogen also provides enough glucose in the bloodstream for other cells in the body to generate energy (ATP). However, as early starv...
5.22 Understand not memorize metabolism: Early starvation: Glycogenolysis
Просмотров 365 месяцев назад
5.22 Understand not memorize metabolism: Early starvation: Glycogenolysis
5.21 Understand not memorize metabolism: Postprandial: Protein digestion and absorption
Просмотров 145 месяцев назад
5.21 Understand not memorize metabolism: Postprandial: Protein digestion and absorption
5.20 Understand not memorize metabolism: Postprandial: Amino acid synthesis
Просмотров 195 месяцев назад
5.20 Understand not memorize metabolism: Postprandial: Amino acid synthesis
5.19 Understand not memorize metabolism: Postprandial: Lipid transport
Просмотров 165 месяцев назад
5.19 Understand not memorize metabolism: Postprandial: Lipid transport
5.18 Understand, not memorize metabolism: Postprandial: Lipid digestion and absorption
Просмотров 255 месяцев назад
5.18 Understand, not memorize metabolism: Postprandial: Lipid digestion and absorption
5.17 Understand not memorize metabolism: Postprandial: Pentose phosphate pathway
Просмотров 5365 месяцев назад
5.17 Understand not memorize metabolism: Postprandial: Pentose phosphate pathway
5.16 Understand not memorize metabolism: Postprandial: Cholesterol synthesis
Просмотров 5485 месяцев назад
5.16 Understand not memorize metabolism: Postprandial: Cholesterol synthesis
515 Understand not memorize metabolism: Postprandial: Amphiphilic lipid synthesis
Просмотров 246 месяцев назад
515 Understand not memorize metabolism: Postprandial: Amphiphilic lipid synthesis
514 Understand not memorize metabolism: Postprandial: Triglyceride synthesis
Просмотров 446 месяцев назад
514 Understand not memorize metabolism: Postprandial: Triglyceride synthesis
5.13 Understand not memorize metabolism: Postprandial: Fatty acid synthesis
Просмотров 766 месяцев назад
5.13 Understand not memorize metabolism: Postprandial: Fatty acid synthesis
5.12 Understand not memorize metabolism: Postprandial: Glycogen synthesis
Просмотров 376 месяцев назад
5.12 Understand not memorize metabolism: Postprandial: Glycogen synthesis
5.11 Understand, not memorize metabolism: Postprandial, fasting and starvation states
Просмотров 646 месяцев назад
5.11 Understand, not memorize metabolism: Postprandial, fasting and starvation states
5.10 Understand, not memorize metabolism: Inhibitors and uncouplers of ETC/OP
Просмотров 496 месяцев назад
5.10 Understand, not memorize metabolism: Inhibitors and uncouplers of ETC/OP
5.9 Understand, not memorize metabolism: PDH, TCA, ETC/OP pathway defects
Просмотров 277 месяцев назад
5.9 Understand, not memorize metabolism: PDH, TCA, ETC/OP pathway defects
5.8 Understand, not memorize metabolism: Oxidative phosphorylation
Просмотров 437 месяцев назад
5.8 Understand, not memorize metabolism: Oxidative phosphorylation
I like the slide with the fox eating popcorn :D
Thanks!
Thank you!
You're welcome!
U should make a video on thermodynamics basics for Biochem!! Thanks for your work im a fan Ps: Sorry for my english
Thanks for the idea!
Thank you for these videos! They have been one of the best resources for learning & reviewing biochemistry.
Glad you enjoy the videos!
As a dietetic student this channel looks amazing, i always thought biochemistry is an essential subject to understand the human body and nutrition but is usually teached the wrong way, only memory learning and zero understanding, i have high expectations about this channel!
Glad you enjoy the videos!
Keep the knowledge flowing, whoop whoop!
Will do-thanks for your support!
This is fantastic! You are an incredible communicator, thank you for making these!
Glad you like them!
I love these videos, they help me preparing for my BC exam as BC bachelor because they take the students perspective in consideration (what is important? why is it important?/negative examples) and highlight the specifics to improve understanding, rather than dumping a lot of information 💛
Glad to know the videos are helpful and thank you for your support. Appreciate it!
thank you for the great content!
nice
Glad you liked it!
Thank you very much. I really liked the interactive part with the pause to think! And love the real life example with DNP, I will definately remember that! Same with CN and complex IV +1 sub
Glad you enjoyed it!
🎉🎉🥳
Thanks!
great video! maybe a vid on biilrubin and heme next?
Yes, in the near future-thank you
Really good video doctor..thank you
Glad you liked it
really good videos, kepp them coming man
Thanks, will do!
Congratulations!!!!!! I am a student of Microbiology. First of all if this questions "Why are we here, what is the purpose of life.....what is the difference between an animal and us(we human beings)" are haunting you...and if you are genuinely looking for its answers then congratulations 😊. Firstly , You are not this body which is made up of some biochemical.You are beyond your body..... beyond your mind(You are beyond matter).You are internal Soul(a spiritual entity).And you have a higher purpose in you human life rather than Eating- Sleeping- Mating- Defending . If you wanted to know (genuinely)about this answer then you should read(atleast once in your lifetime......so that you don't have any regret in the time of your Death) "Srimad Bhagavad Gita as it is " by HDG AC Bhakti Vedanta Swami Prabhupada , Founder acharya of international society for Krishna consciousness, ISKCON ....popularly known as Hare Krishna Movement.Then, you will get all of your answer. Disclaimer :This message is for those who GENUINELY looking for this answer. Hare krishna🌸
Thank you for your support of this channel and comments about the wisdom of eastern philosophies
Thank you
Welcome!
P r o m o S M 😣
Excellent introduction to the fascinating world of glycocalyx.
Glad you enjoyed it. Thank you for your feedback.