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Behavioural Genomics
Добавлен 19 июн 2018
These are the PROBLEMS in Human Trait Genetics
Open Challenges in Human Trait Genomics: genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02697-9
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Видео
Do you have the warrior or the worrier gene? Effect of mutation in the COMT gene on personality.
Просмотров 6 тыс.11 месяцев назад
Do you perform at your best under pressure? Or do you prefer to environments where you have time think? A little of both? This gene may influence how you respond to stimulation.
Twin and Adoption Studies - Nature and Nurture in Personality and Behaviour
Просмотров 3,5 тыс.2 года назад
The cause of individual differences in behaviour and personality is one of the most hotly debated subjects in the history of psychology. This video gives and overview of the history and impact of twin and adoption studies and what they tell us about the source of individual differences in behaviour and personality.
Polygenic Scores - Genome-Wide Association Studies Explained Simply Part 5
Просмотров 4,1 тыс.4 года назад
One of the uses of Genome-Wide Association Studies is the development of polygenic scores. This video describes how they are produced, what they can tell us and how they are used.
Linear and Logistic Regression - Genome-Wide Association Studies (GWAS) Explained Simply Part 4
Просмотров 7 тыс.4 года назад
In this video we discuss how to find associations between continuous and dichotomous traits and genetic variants.
P-values and Multiple Testing - Genome-Wide Association Studies (GWAS) Explained Simply Part 3
Просмотров 4,5 тыс.4 года назад
Part 3 of this series on Genome-Wide Association Studies. Here we look at P-Values and the issue of multiple testing. I'm looking for a job btw, so if you know anyone who is hiring bioinformaticians/statisticians please drop me an email at paulcraig545@gmail.com And of course, if you have any questions or suggestions for future videos please leave a comment below.
Linkage Disequilibrium - Genome-Wide Association Studies (GWAS) Explained Simply Part 2
Просмотров 9 тыс.4 года назад
Part two if this video series on Genome-Wide Association Studies (GWAS). Here we look at linkage disequilibrium and the advantages and challenges it poses to detecting genetic variants associated with complex traits such as predispositions to certain behaviours. Read this video as a blog post: behaviouralgenomics.blogspot.com/2020/05/genome-wide-association-studies-part-2.html Article which exp...
Genetic Variation and Traits - Genome-Wide Association Studies (GWAS) Explained Simply Part 1
Просмотров 3,6 тыс.4 года назад
This video explains how genome wide association studies are used to identify genetic variants associated with different biological and behavioural traits.
Introduction to Behavioural Genomics
Просмотров 8794 года назад
Short introduction to the field of behavioural genomics. You can view the contents of this video as an article here: behaviouralgenomics.blogspot.com/2020/05/introduction-to-behavioural-genomics.html
Where do you test for this?
Awesome and insightful video.👏
What is the test that determines the genes of the warrior?
On a side note, isn't it somewhat unhelpful to put personality connotations to this as hero vs philosopher. I mean afterall at the end of the day it is about stimulation, and I am sure a lot of famous philosophers could've been both (worriers and warriers and in between). I think Philosophy, if going by the card sorting analogy, requires both kind of people.
I'm not going to lie... your pronunciation of 'warrior' and 'worrier'... a bit confusing...
I have the warrior gene 2x more according to promethease. I was a soldier in Iraq for several years & while I hate disorganized leadership, I prefered to be in the frontline bec I have a feeling that the job wilk get done quicker than somebody who is scared & lazy. I love martial arts & combat sports. I don't mind a messy room & have more success in business than in the classroom.
If you think you have the warrior gene cause you're lazy, you don't
Wouldn't epistatic effects create a non "Gaussian distribution" of complex traits in populations? Not to mention they'd be the easiest to drive into fixation.
@@Voidapparate Interesting. Why would that be?
Warrior/ worrier isn’t the greatest phrase to follow with a Scottish presenter
So I have come to understand :(
great explaination
Y theory is that Europe's rise is also given due the relative balance of warrior and worrier with a light dominance of worrier
@@MichaTheLight I'd advise against speculating anything which could be interpreted as genetic superiority of one group of people over another. I think it is more likely that the geographic factors which led to Europe's economic success also created an environment which selects for the worrier variant.
@@behaviouralgenomics438 Why must always the woke reflex come by just an argument. I didn't even say superiority. I didn't even say it would be true and I didn't even say it could be the sole reason.
@@MichaTheLight I know you didn't say superiority which is why I said "could be interpreted as...". No woke moralising intended. In any case that wouldn't explain why Europeans have this ratio to begin with so it would again push the problem back to environment.
@@behaviouralgenomics438 okay a misunderstanding. I was sometimes judged for just bringing an argument forward which wasn't connected to any political stuff. I think it's both environment forms ppl but ppl also form environment.I studied Anthropology and it was taboo to make rational arguments based on genetics I'am aware that the national or ethnic character is produced by the combination of many genes. There are constantly tiny changes which amount to evolution over long time spans.
I'm just erect
Great presentation! I appreciate how clearly and concisely you covered the topic. Thank you for sharing it.
Thank you, I am glad you enjoyed it
Very interesting😊
Thank you
I find the assumption of additive dominating a bit strange. Whenever I studied specific genes whose mechanism of action is known (e.g. that protect plants from drought) their effect is massively dependent on other genes and the environment. I fear that scientists assume interactions don't matter because it'd be almost impossible to study this if they did, so it's convenient to pretend they don't matter.
For polygenic traits it is simply not feasible to do so. Especially when you are dealing with associated SNPs and not a known causal mechanism.
@@behaviouralgenomics438 - agreed. But I suspect knowing that it can't be tested, has led scientists to want it to not matter that it can't be tested. I read a paper ages ago (sadly forget the title) about how the desire for things to be mathematically or empirically tractable leads scientists astray sometimes. I hope additive influence dominants though, i want it to be testable !
I'm a homozygous worrier and I feel like I have more "patience" with monotonous and mundane activities. I can even feel a slight pleasure in doing repetitive activities, how crazy is that! Even though I'm homozygous, I feel like I can react well to mild or moderate stress situations. However, at the same time I have had Post Traumatic Stress at work, I have anxiety and depression. I take the antidepressant venlafaxine and it has helped me a lot with my anxiety, my psychiatrist said that it regulates Dopamine.
Had a pretty hard time distinguishing if you were saying worrier vs warrior while I was listening at work. I'll have to watch it again with subtitles. Best presentation of the subject I've seen on RUclips yet.
@@aic-gz3rz It's one of the downsides with a Scottish accent. That and "purple burglar alarm"
I think worrier has more dopamine
Fighter & Entrepreneur here. I only feel good whenever I do something hard, stressful or entertaining. I also tend to have ADHD symptoms. Didn't know genetics played such a big role. Awesome video.
i have the warrior variant of the gene and on my days off i never get anything i wanted to accomplish done just procrastinate endlessly but at work as a line cook when there is food orders streaming down the the floor from the printer i run circles around everyone like a tasmanian devil from loony toons
a interest contrast is there is one co-worker who def has the worrier variant and the pros is he never forgets anything that needs to be done throughout the day while ill miss things like making gravy as an example, nothing like that gets passed him. but when it gets busy he does shutdown and goes into a quiet support role like taking care of putting bread for a clubhouse into the toaster and filling up sauce cups for the next order coming up, its actually nice combo we got going on line when together
@@Joule_Frog This was my first thought as well; are the warriors procrastinators? I haven't tested yet, but I know for a fact that back in university I needed to delay tasks to build up pressure for me to get locked in before a deadline and perform well. It was like starting early writing didn't stimulate me enough.
@@LG-bi1srRaid. Sleep on a pile of corpses and riches. Exhaust resources. Raid.
I don’t relate to either of these. I was diagnosed with adhd pretty late in life, always had low executive function and was disorganized, got in trouble in school for being too talkative, typical adhd treats. However, I always excelled in more boring tasks. I did well in school and went to an Ivy League school, and have sucked at warrior tasks, like sports and anything physical
Incredibly informative video. I am a homozygous warrior, and it makes complete sense as I am simply unable to concentrate on mundane tasks such as assignments
Excellent presentation! Loved it. Based on the knowledge and expriences i have about myself, i am heterozygous. I love to move around and live in expanded steppes and mountains and do martial art and horseriding and sharpshooting, and at the same time i enjoy sitting and spending countless hours on math and physics as im studying physics and philosophy at uni. + i love scottish teachers they are the best teachers i ever had in my life, learned faster with them. Keep up the great work!
Thank you for sharing this!
I have both.
Awesome! I am homozygous worrier.
Very fair and thorough explanation!
It's a little confusing that warrior and worrier nearly sound identical haha. Need a different name for worrier.
Disadvantages of the Scottish accent 😅
How does gender fit into this? the pathologies table could easily map into a list of standard gender differences
Since this gene is not on the X or Y chromosome, sex and/or gender does not fit into this.
There is a large literature about the moderating effect of gender on the associations between COMT polymorphisms and behaviour. To include it would have made the video too long. Oestrogen also regulates prefrontal cortical dopamine so there is certainly an interaction between sex and COMT status.
“As mortals, we're ruled by conditions, not by ourselves.” ― Bodhidharma
That's a great quote.
We are ruled by conditions and by ourselves. We can also change conditions.
we are part of the conditions
LOL, total BS
I was adopted. I ended up on drugs for ten years. My adopted family has zero history, and i had unconditional love. I swear there is something to this.
Thank you for your personal perspective on this topic
I am sorry for your trials and I hope things are better for you now. You may enjoy reading The Neuroscience of Addiction and Blueprint How DNA Makes Us Who We Are. The common thread of both texts is that genetics build more of our basis than many people are comfortable admitting. The second book states that genes are probabilistic, not deterministic. However, such probabilistic genes can push people towards certain behaviors and outcomes.
My biological parents unconditionally love me and have zero history with drugs. But I've struggled with it. I attribute it to my dumb choices instead of my genetics.
Wow! Just exactly what I was looking for! Thanks for the very clear explanation.
🌻
👍👍👍
THANK YOU THANK YOU
5e-8 is lenient if you say it's 3.3mio independent common SNPs.. should be p-values less than 1.5e-8 if so.. what is the explanation for this? It's even more lenient if you consider how many researchers are using the same UK biobank data to tests probably thousands of different hypothesis...
Beautifully introduced. Thanks
Thank you! Great video.
Great video...concepts are introduced and explained with amazing clarity..thank you
That’s a very helpful, clear and interesting video, thank you! It should be shared with psychology undergrads at the very least!
Thank you!
A good summary. The university of Minnesota course on this has a really good explanation of the logic behind twin studies if you haven't seen it. I wish heritabiliy was easier to interpret.
I'll check it out, thank you!
Perfectly explained! Thank you!!
Extremely helpful! Thank you!
Very nice introduction!
Excellent video.
Amazing explanation.. hope you can do more videos
This is great! Thank you so much for preparing this video. I found it extremely helpful :o)
Phenomenal video!!! Thank you for drawing the connection between linkage disequilibrium and haplotypes. The absence of this connection increases confusion when texts explain LD blocks (haplotypes) that ARE associated with diseased alleles. It’s easy to question “just because two alleles are linked doesn’t mean a diseased allele is nearby, right?”, but the fact that linkage disequilibrium creates haplotypes/LD Blocks makes this much more reasonable to understand how these haplotypes can indicate diseased states. Having this said, without actually genotyping the intervening exons and introns… how can we say for certainty the haplotype is pure to the reference and isn’t experiencing an alternative mutation?
Thank you so much. The video was clear and precise and helped me understand the concepts 🔥
can you do walk through of GWAS analysis using plink or and R?
Very good, I like your accent.