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Interestingly, mutations in the exon 1-3 in IL12RB2 could lead to upregulation of stemness and a lack of differentation due to defective JMJD3-dependent demathylase of H3K27me3/2 as well as defective JMJD3-dependent Brg1 in the SWI/SNF complex while cooperating with T-bet-mediated H3K4me3. The time point for the upregulation of IL12RB2 mRNA and protein expression, which takes place upon IL-2-induced STAT5 activation before the clonal expansion of T-cells and differentiation of TH1, could be an important interface for epigenetic mechanisms regulating chromatin accessability during T-cell differentiation and T-cell mediated maturation/priming of DCs,- possibly regulating both T-cell lineage commitment, APC maturation and the final exit from innate to adaptive immunity. Furthermore, IL12RB2 is expressed in both neuronal and epithelial (including thymic) cells, which could be interesting to study due to potential crosstalk mechanisms between T-cells and cancer cells with a stem-like gene signature. In T-cell/DC crosstalk, the early expression of IL12RB2 mRNA seems connected to activation of p38 mapk phosphorylation (H3S10ser), which is positioned in the important CD40L-CD40 axis and leads to finalisation of the innate type 1 IFN response and correct transition into the adaptive,- even controling the confirmational switch between early TGF-beta-dependent IL-12p70 production and p38 mapk-dependent IL-12p70 via mediating the full transcription of the IL-12p35 subunit. The dynamics of T-bet-defecient cells as well as IL12RB2-defecient cells (if defecient in the first exons,- exon 1-3 and intragenic regions), show a prolonged IFN-alpha production and a defective negative regulation of the type 1 IFN gene signature which suggest a delayed transition to adaptive immunity, as seen in TLR9 stimulation...

MDS/AML with mutated TP53 is in the ICC

SOMATIC MUTATION THEORY IS FRAUD CANCER IS A METABOLIC DISEASE OTTO WARBURG

Thank you Cancer Genomics Consortium. Greetings from Molecular Biology, Env. and Cancer Research Group, universidad del Cauca, Colombia.

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Thank you CGC.

youtube.com/@hironyarabha1959?sub_confirmation=1

Thank you so much. Greetings from Molecular Biology, Env. and Cancer Research Group (Bimac) at Universidad del Cauca, Colombia.

One quick question that have you used hybrid capture probes for this work?

Bionano Genomics? Hello?

Hello plz i really need your help what if i have to elaborate on the qualities that a biochemical change should posses for it to be used as an ideal biomarker

Can I get your email ID please, my wife's age 35yrs has been diagnosed with AML, with normal female karyotype and NGS showing an ETV6 mutation with amino acid change p.(N405Afs) *19

I couldn't agree more. Great Video 💎! You are late to the party > P-R-O-M-O-S-M!

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Nice presentation.