ProImmune thinkpeptides
ProImmune thinkpeptides
  • Видео 223
  • Просмотров 139 800
ProImmune T cell Proliferation Assays
ProImmune boasts a wealth of experience and expertise in conducting ultra-sensitive CFSE T cell proliferation assays.
Our repertoire includes the routinely applied ProMap® T cell proliferation assays , engineered to exquisitely discern peptide epitopes that elicit helper T cell proliferation. Furthermore, the sophisticated ProScern® DC-T cell proliferation assay is tailored to enable meticulous comparisons of whole protein to identify immunogenicity risks. Complementing these techniques is the Mixed Lymphocyte Reaction (MLR) assay a cornerstone in assessing immune modulation.
With ProImmune’s precision and rigor, alongside industry-leading customer service, unraveling the intricacies of imm...
Просмотров: 406

Видео

ProPresent Antigen Presentation Assay Webcast
Просмотров 1715 месяцев назад
Join our Senior Immunology Sales Specialist, Dr. Emilee Knowlton in this webinar as she describes ProImmune’s experience in evaluating therapeutics, enzyme replacements, gene therapy vectors, cancer antigens and much more. In this webinar she shares several case studies highlighting groundbreaking advancements in the field of immunology using the ProImmune Antigen Presentation Assay. ProImmune’...
Ashley Curran: Citrullination alters antigen processing and presentation by revealing epitopes in RA
Просмотров 1795 месяцев назад
Full title: Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis. Ashley Curran recently received her PhD in Immunology from the Johns Hopkins University School of Medicine and is now a Postdoctoral Fellow at the Medical University of Vienna. Her doctoral research focused on the molecular mechanisms underlying the pathogenesis of cit...
Alexander Nicols: Understanding the Impact of Hybrid Immunity on SARS-CoV-2 T Cell Memory
Просмотров 1445 месяцев назад
Alex Nicols obtained a BSc in Medical Microbiology and an MSc in Molecular Medicine from the University of Sheffield Medical School where he studied the virulence factors of Burkholderia pseudomallei. He obtained a PhD in Translational Immunology from the Newcastle University Translational and Clinical Research Institute where he worked closely with the Great North Childrens Hospital investigat...
Genevieve Clutton: CD3 downregulation identifies high-avidity human CD8 T cells
Просмотров 1555 месяцев назад
Genevieve Clutton is a Research Associate at the University of North Carolina at Chapel Hill. She received her doctorate from the University of Oxford, where she studied the role of T cell-derived IL-10 in HIV-1 pathogenesis. In 2014, she moved to Chapel Hill, initially joining the University’s HIV cure program and elucidating the effects of putative HIV latency-reversing agents on HIV-specific...
Emilee Knowlton: MHC Class I Pentamers and MHC Class II Tetramers to track antigen-specific T cells
Просмотров 1025 месяцев назад
Successful immune monitoring programs are dependent on reliable research tools for tracking antigen specific T cell responses. The Pro5® Pentamers are the most published commercial Class I tool for measuring antigen specific CD8 T cells with over 700 catalog specificities available. The ProT2® Tetramers for enumerating antigen specific CD4 T cells are pre-labelled or available as biotinylated m...
Máté Manczinger: Neoantigen repertoire in the context of HLA class I shapes antitumor immunity
Просмотров 655 месяцев назад
Full title: Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity. The HLA-I molecules help our immune system fight off diseases and cancer by recognizing specific peptides. Some HLA-I variants can bind a wide variety of peptides, which could be helpful against viruses but its implications on cancer immune response are unknown....
Kevin Maringer: Role of mosquito NF-κB-mediated innate immunity in control of virus transmission
Просмотров 1105 месяцев назад
Full title: The role of mosquito NF-κB-mediated innate immunity in controlling vector-borne virus transmission and emergence Despite their evolutionary divergence, insects share many (but not all) immune responses with humans and other vertebrates. Many major breakthroughs in the field of immunology were first made or built upon in insects, particularly the fruit fly Drosophila melanogaster. Th...
Peter Eggenhuizen: Autoantigen-specific T regulatory cells halt the progression of lupus nephritis
Просмотров 1725 месяцев назад
Regulatory T cells (Tregs) are crucial for maintaining immune homeostasis and preventing autoimmunity. Autoantigen-specific Tregs are known to potently and specifically suppress autoimmunity, indicating their potential to be engineered as a cell-based therapy for autoimmune diseases. Systemic lupus erythematosus (SLE) and its more severe manifestation, lupus nephritis (LN) are associated with a...
Sam Benton: Ankyrons™: Next-generation target-binding reagents beyond antibodies
Просмотров 1575 месяцев назад
Ankyrons™ are a novel class of small target binders based on an ankyrin-repeat scaffold. In this talk we discuss how Ankyrons™ break free from the limitations of traditional antibodies. These highly stable, recombinant single-domain proteins offer a fresh perspective for researchers seeking precise target binding solutions. Real-world case studies are shared, where Ankyrons™ stepped in to bridg...
ProImmune Ankyron Webinar 29Jan2024
Просмотров 2987 месяцев назад
In this webcast, we explore the next generation of target binding reagents, moving beyond the conventional antibody-centric paradigm of target binders. Dr. Louise Johnson, and Ankyron product specialist Sam Benton, introduce participants to Ankyrons™, a novel class of small target binders based on an ankyrin-repeat scaffold. During the session, we discuss how Ankyrons™ break free from the limit...
Koen Venken: Modulatory roles of Tregs in gut vs joint inflammation in TNF-driven spondyloarthritis
Просмотров 10211 месяцев назад
Full title: Understanding the role of T cells in SpA: Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis Gut and joint inflammation commonly co-occur in spondyloarthritis (SpA) which strongly restricts therapeutic modalities. The immunobiology underlying differences between gut and joint immune regulation, however, is poorly u...
Mastering Immunity 2023: Experts Panel Discussion Session 2
Просмотров 8311 месяцев назад
With Prof. Koen Venken, Dr. Joshua Blight, Noor Zayanah Hamis, Georgia Stavrakis Prof. Koen Venken has a longstanding interest in T cell biology with a primary focus on translational research. He completed his PhD at the Biomedical Research Institute of the University of Hasselt (Belgium) and Maastricht (The Netherlands), looking into the role of human Tregs in multiple sclerosis. For his post-...
Charlotte Thompson: Ankyrons: The future of target-binding reagents beyond antibodies
Просмотров 10211 месяцев назад
Ankyrons™ are next-generation target binding reagents provided by ProImmune that overcome many of the current constraints of research antibodies. They are highly stable recombinant single-domain binders that can be directly labelled or detected via an epitope or biotin tag. Ankyrons can be engineered to combine them with further Ankyron or other domains much more easily than even recombinant An...
Edmund Neo: Application of ProPresent® Antigen Presentation Assay to Assess Immunogenicity
Просмотров 8711 месяцев назад
ProPresent® is ProImmune’s MHC-associated peptide proteomics (MAPPS) assay. It lets you directly identify the peptides which are presented by antigen-presenting cells to T cells. Our core assay has a turnaround time of just 3-4 weeks. ProPresent® tells you exactly which epitopes from your biotherapeutic drug or other protein of interest are presented by HLA molecules to T cells. Peptides are id...
Mastering Immunity 2023: Experts Panel Discussion Session 1
Просмотров 7111 месяцев назад
Mastering Immunity 2023: Experts Panel Discussion Session 1
Georgia Stavrakis: Pre-conjugation of MHC Pentamers for simultaneous analysis of ag-specific T cells
Просмотров 5511 месяцев назад
Georgia Stavrakis: Pre-conjugation of MHC Pentamers for simultaneous analysis of ag-specific T cells
Noor Zayanah Hamis: Role of skin-based T cell immunity in acute dengue infection
Просмотров 7211 месяцев назад
Noor Zayanah Hamis: Role of skin-based T cell immunity in acute dengue infection
Jennifer Malcolm: C-term citrullinated peptide alters APC-CD4 T cells leading to breach of tolerance
Просмотров 5511 месяцев назад
Jennifer Malcolm: C-term citrullinated peptide alters APC-CD4 T cells leading to breach of tolerance
Peng Li: Immunogenicity Assessment during the development of antibody therapeutics
Просмотров 14311 месяцев назад
Peng Li: Immunogenicity Assessment during the development of antibody therapeutics
Narasimha Rao: FDA recommendations on immunogenicity risk assessment for synthetic peptide drugs
Просмотров 74411 месяцев назад
Narasimha Rao: FDA recommendations on immunogenicity risk assessment for synthetic peptide drugs
Yoonjoo Choi: Protein deimmunization by T cell epitope deletion
Просмотров 12711 месяцев назад
Yoonjoo Choi: Protein deimmunization by T cell epitope deletion
An Integrated Approach and Strategies to Mitigate Immunogenicity Risk
Просмотров 284Год назад
An Integrated Approach and Strategies to Mitigate Immunogenicity Risk
Evaluating immunogenicity risk of complex peptide products
Просмотров 507Год назад
Evaluating immunogenicity risk of complex peptide products
Pro5 MHC Class I Pentamers
Просмотров 425Год назад
Pro5 MHC Class I Pentamers
Ankyrons: the future of target-binding reagents beyond antibodies
Просмотров 514Год назад
Ankyrons: the future of target-binding reagents beyond antibodies
Jeremy Fry: Ankyrons: The future of target-binding reagents beyond antibodies
Просмотров 245Год назад
Jeremy Fry: Ankyrons: The future of target-binding reagents beyond antibodies
Akshay Binayke: Proinflammatory cytokines & metabolomic signatures shape T cell response in COVID-19
Просмотров 133Год назад
Akshay Binayke: Proinflammatory cytokines & metabolomic signatures shape T cell response in COVID-19
Daniela Weiskopf: Immune responses induced by SARS-CoV-2 vaccination
Просмотров 84Год назад
Daniela Weiskopf: Immune responses induced by SARS-CoV-2 vaccination
Helen Wagstaffe: Kinetics & phenotype of T cells after SARS-CoV-2 challenge of seronegative adults
Просмотров 62Год назад
Helen Wagstaffe: Kinetics & phenotype of T cells after SARS-CoV-2 challenge of seronegative adults

Комментарии

  • @warningsigns4526
    @warningsigns4526 23 дня назад

    what Phd compiled these stupid charts?

  • @warningsigns4526
    @warningsigns4526 23 дня назад

    THESE DRUG COMPANIES ARE PSYCHOPATHS

  • @warningsigns4526
    @warningsigns4526 23 дня назад

    IS THT A REAL PERSON GIVING YOU LIP SERVICE?

  • @user-be2zk7xx4n
    @user-be2zk7xx4n 2 месяца назад

    Great , but still waiting for a complete way to cure taupathy 😢

  • @lane5480
    @lane5480 3 месяца назад

    *promosm*

  • @SophiaTheAll-Knowing
    @SophiaTheAll-Knowing 4 месяца назад

    When you smoke a cigarette it citrullinates your lungs, so it definitely tracks that citrullination would have the effect on RA you described :)

  • @minouagah8280
    @minouagah8280 5 месяцев назад

    Hello i am suffering from some infection is your clinic offers doctor visit and treatment virtually?

  • @minouagah8280
    @minouagah8280 5 месяцев назад

    Please let me know thanks

  • @minouagah8280
    @minouagah8280 5 месяцев назад

    Do you have testing too

  • @minouagah8280
    @minouagah8280 5 месяцев назад

    Still is this treatment available

  • @EffYouMan
    @EffYouMan 6 месяцев назад

    Cellular science is a joke

  • @ajaylale1579
    @ajaylale1579 7 месяцев назад

    Thank you for the detailed presentation. As mentioned in the presentation, we need to perform the studies for each strength. But, for comparative PK studies such as bioavailability bioequivalence study, we can get biowaiver for lower strength based on the results of higher strength study and linearity in the PK profile. Is it possible to waive the innate immunogenicity study for lower strength based on the results of immunogenicity study at higher strength?? Which parameters will play role here for comparison. If the study cannot be exempted, why??

    • @tatrajuramchandra6909
      @tatrajuramchandra6909 Месяц назад

      It's my point of view.... I think it is not possible because innate immune response is completely depends on how the impurities provoke the immune response, whether it is low strength or higher strength (may be high strength getting more impurities but we cannot ensure that lower concentrations getting less impurities)

  • @il3mendo
    @il3mendo 9 месяцев назад

    Doctor what if il 15 needs to elaborate antibodies, such IgA, with DN CD 4, DN CD 8 and positive cd3 ? Does TCR beta gamma+ support the production ? A double negative t Cell in the duodenum means that the t Cell are naive ? Do we see these type of situation with some immunodeficiencies ? NK should express IgG and IgE, are then IgM and IgA needs TCR reception to binds the Memory Cell ? Can also Il 15 ( Active in celiac disease, i know the tipic Is different), loose his ability to generate antibodies ? Thanks

  • @caliguy1260
    @caliguy1260 Год назад

    The density of “uh” instances is really distracting.

  • @thethinker8473
    @thethinker8473 Год назад

    Katie Ewer, your ego of knowing it all is bigger than a house, when real scientist and real evidence is silenced, someone like YOU, should never be allowed to work again!!!

  • @rittenbrake1613
    @rittenbrake1613 Год назад

    Thank you ! very helpful !

  • @SURVIVE_JUL52073
    @SURVIVE_JUL52073 Год назад

    I JUST DONT UNDERSTAND WHY THAT THERE IS SO MANY SMART PEOPLE OUT THERE BECAUSE OF CURIOSITY ... BUT TELL ME WHY ARE THESE SMART PEOPLE NOT CREATING A UNIVERSAL PROTEIN THE REJECTS ANY AND ALL SPIKE PROTEINS OR FOREIGN PROTEINS ... SO YEAH THIS COVID IS ABOUT MONEY AND CONTROL AND OVER WHELMING AMOUNT OF DOCTORS WANTING MORE SICO PEOPLE. ... CREATING A PROTEIN THAT WILL REJECT ALL FOREIGN PROTEINS SUCH LIKE SPIKE PROTEIN WOULD ERADICATE COVID, FLU, RSA, AND ALL VIRUSES EFFECTING HUMANS. DID THE INTELLIGENCE UNIT THINK THAT WE MAY BE INVADED NY ADVANCED LIFE (ALIENS) SO THEY CREATED MAN MADE VIRUSES SUCH LIKE COVID AND THE ALIENS WONT ATTACK!!! LOL SERIOUSLY CREATING A SINGLE SEQUENCE PROTEIN TO REJECT SPIKE PROTEINS IS THE KEY TO ERADICATING ALL VIRUSES TO THE HUMAN BODY AND THAT IS ALSO THE ANTI AGING PROTEIN WHICH REJECTS FOREIGN PROTEIN AND RETAINS NATURALLY HIGH ANTI OXIDANTS. WAIT UNTIL THE WORLD READS KR HEARS THIS WHAT I SAY!!! THE WEALTHY WILL PAY TO BLOCK IT OR DESTROY IT!!!

  • @chiefwakanda2889
    @chiefwakanda2889 Год назад

    Would you be able to work out some examples of how to determine who is more at risk for a disease based on looking at their HLA type? Thank you

  • @nikolai8850
    @nikolai8850 Год назад

    քʀօʍօֆʍ 😭

  • @iceshcratiote3635
    @iceshcratiote3635 Год назад

    really think

  • @samsungsarsamsungsar7792
    @samsungsarsamsungsar7792 2 года назад

    آنتی‌بادی خنثی کننده واکسن در برابر سویه‌های مختلف 11:17 عوارض واکسن 12:29

  • @samsungsarsamsungsar7792
    @samsungsarsamsungsar7792 2 года назад

    Iran forbids importing vaccines made by U.S companies like Pfizer. So many people died.

  • @michelebarnett718
    @michelebarnett718 2 года назад

    When can we have this vaccine in Australia? Please 🥹

    • @craigwelch8916
      @craigwelch8916 8 месяцев назад

      "When can we have this vaccine in Australia? " When Professor Petrovsky has sufficient data to support an application for approval to the TGA. He has not yet done so.

  • @user-kh1fn8qe8k
    @user-kh1fn8qe8k 2 года назад

    Many Australians are cheering you on Professor, and wishing you success with Spikogen.

  • @Updogg3000
    @Updogg3000 2 года назад

    The people in the crowd must be living on a prayer to stay awake during this humdinger of a performance!

  • @topperharley9182
    @topperharley9182 2 года назад

    Love me some Petrovsky!

  • @julzee111
    @julzee111 2 года назад

    The spike protein is a damn bioweapon. So are we supposed to be happy about this. Take your spike protein and …

  • @LAMBOTRAGIC
    @LAMBOTRAGIC 2 года назад

    Any joy with the WA government in relation to approval for the trial in this state?

  • @sharifhammaseyoumar415
    @sharifhammaseyoumar415 2 года назад

    Great experience I had with u dr ajhe RUclips channel. After using ur herbal medications as Prescribed by you ,my herpes disease became a thing Of the past . All thanks to you Dr ajhe channel…….

  • @gedionkyng3413
    @gedionkyng3413 2 года назад

    Meeting #Droziengbe on RUclips has really change my life, after many years of suffering I have finally been cured from Genital Herpes thanks #Droziengbe God bless you🌿..

  • @ebrelus7687
    @ebrelus7687 2 года назад

    Stop authoritarian sanitarism open access to cheap anticovid drugs without patent monopoly.

  • @mrnji415
    @mrnji415 2 года назад

    Man this guy wow

  • @anaherpes2501
    @anaherpes2501 2 года назад

    Herpes total cure thanksgiving to #Doctorojie Channel for helping me cure my herpes

  • @esrakayikci934
    @esrakayikci934 2 года назад

    His accent is really hard to understand and he speaks very fast. I was very curious about the subject, I listened twice, but I couldn't understand clearly. I wisch it was spoken in an understandable way.

  • @johnseltzer7735
    @johnseltzer7735 2 года назад

    More bull shit from Kim and Kate or Humpty Dumpty and Crew

  • @BlazingBigJointz
    @BlazingBigJointz 2 года назад

    Merck, those nazis never were defeated...

  • @govindasharma5122
    @govindasharma5122 2 года назад

    Here's a link to a talk I gave early 2021 with some updates and new perspectives: ruclips.net/video/776qAB_9YuU/видео.html

  • @surnbe
    @surnbe 2 года назад

    24:58 "Cells have drastically different CODON usage in their transcriptome and also they may have different tRNA levels. So, figuring out the translational kinetics of a protein in one tissue..that tells you nothing about the translational kinetic seen at different tissues"

    • @zacparatore296
      @zacparatore296 2 года назад

      I know nothing about this stuff but is it safe to say that this type of science and the different buffers they use in the vaccines which they say have no affect is what causing all these new variants with crazy mutations. Not to mention the potential genetic diseases in people down the road?

  • @surnbe
    @surnbe 2 года назад

    5:30 is a very interesting point

  • @leonluis1041
    @leonluis1041 2 года назад

    I appreciate Dr. Gbenga for his herbal medicine which cured me of hepatitis B since may 2, 2021 after series of medication , am happy finally am free from hepatitis B.

  • @mimimimi-ls7po
    @mimimimi-ls7po 3 года назад

    Think natural medicine for human beings

  • @emadbagheri
    @emadbagheri 3 года назад

    The mark

  • @hasiburrahman200
    @hasiburrahman200 3 года назад

    hla b 27 positive and ankylosing spondylitis how can i do

  • @ThekiBoran
    @ThekiBoran 3 года назад

    If Kate downloaded from Chinese computers the genetic sequence for the spike protein used in their jab, how does she know that what they have is the correct sequence? It would seem the actual bug has not yet been properly purified and isolated, even as of mid August, 2021. The only available sequence is in silco isolations which is a crap shoot.

  • @rab-cnesbit4181
    @rab-cnesbit4181 3 года назад

    Has anyone watched "I AM LEGEND " movie , they thought their vaccine from chimps cured cancer......they all turned to zombies

  • @Merovigne
    @Merovigne 3 года назад

    My favorite part is when she skips over the world wide HIV research extended follow up that conclusively showed significant increase in using adenoviral vectors AD1 thru AD56. Since it only increases HIV1 infection for every ethnicity on the planet except .....guess who...this adenoviral vectors target Africans 32 base pair gene ccr5. Only pure caucasians are hetero and homozygous immune to these vaccine vectors. Coincidence? Right? www.ncbi.nlm.nih.gov/pmc/articles/PMC7571904/

  • @edwardtodd98
    @edwardtodd98 3 года назад

    6 weeks later No ex USA phase 3 No delta variant news Hmmmmmmmmmmm another lie from INOVIO ?

  • @johnseltzer7735
    @johnseltzer7735 3 года назад

    Hey Kim and Kate, get on every news outlets and ask why the CDC and FDA will not approve 4800 or 4802 .. Don't hide in the closet get out and expose the FDA and CDC pulling funding on INO..

  • @mordecaigabael673
    @mordecaigabael673 3 года назад

    this what you put in AZ vaccines?its a big concerned you know..we not animal.You says its harmless in the AZ vaccines..but the evidence shows of blood cloth risk...

  • @johnseltzer7735
    @johnseltzer7735 3 года назад

    Kate is not being honest , neither is Kim , there PR or news isn't even relatable.. No P3, no news,no sales , no approved P3.. Nothing ...