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Apellis Pharmaceuticals
США
Добавлен 1 ноя 2018
Apellis is a clinical-stage biopharmaceutical company pioneering the development of novel therapeutic compounds to treat disease by inhibiting the complement system at the level of C3, the central protein in the complement cascade. We are currently conducting clinical trials around the world with our lead candidate APL-2, a complement C3 inhibitor. Our current clinical programs include ongoing phase 2 trials in autoimmune hemolytic anemia (AIHA) and complement-dependent nephropathies, and phase 3 trials in geographic atrophy (GA) and paroxysmal nocturnal hemoglobinuria (PNH).
Find Apellis online and on social media:
Website: apellis.com/
Twitter: apellispharma
LinkedIn: www.linkedin.com/company/apellis
Find Apellis online and on social media:
Website: apellis.com/
Twitter: apellispharma
LinkedIn: www.linkedin.com/company/apellis
PNH, The Role of Complement in PNH, and The Potential of Inhibiting Complement C3
The complement system is an essential and powerful part of our immune defense system. Its main function is to coordinate the destruction and removal of infectious organisms, known and pathogens, or damaged cells in our body that need to be replaced.1 The complement system may be activated by three different pathways - the alternative, classical and lectin pathways that all run through Complement C3, the central protein in the cascade.1 C3 serves as the master switch controlling all downstream effectors that ultimately cause destruction of the cell. In situations where the complement system becomes over activated, it results in immune attack, the destruction of healthy cells, and ultimatel...
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Видео
About Autoimmune Hemolytic Anemia (AIHA)
Просмотров 16 тыс.5 лет назад
Autoimmune hemolytic anemia (AIHA) is a group of rare autoimmune disorders characterized by the premature destruction (hemolysis) of red blood cells (RBCs) by autoantibodies at a rate faster than they can be replaced.1 Most cases of AIHA are classified as either warm antibody (wAIHA, 60% to 70% of cases) or cold agglutinin disease (CAD, 20% to 25% of cases), depending upon the temperature at wh...
AIHA, The Role of Complement in AIHA and The Potential for C3 Inhibition
Просмотров 9 тыс.5 лет назад
The complement system is an essential and powerful part of our immune defense system. Its main function is to coordinate the destruction and removal of infectious organisms, known and pathogets, or damaged cells in our body that need to be replaced.1 The complement system may be activated by three different pathways - the alternative, classical and lectin pathways that all run through Complemen...
APL-2 and C3 Inhibition
Просмотров 1,1 тыс.5 лет назад
When the complement system becomes overactivated, medical treatment is required to regain control and protect the body from immune attacks. APL-2 is a PEGylated cyclic peptide inhibitor of complement C3. PEGylation helps keep APL-2 in the body longer, reducing dosing frequency. The peptide portion of APL-2 binds to C3, exerting broad inhibition of the complement cascade and helping to prevent e...
About Paroxysmal Nocturnal Hemoglobinuria (PNH)
Просмотров 23 тыс.5 лет назад
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, and potentially life-threating blood disorder that occurs when unregulated complement activity causes the destruction of red blood cells (hemolysis) and the formation of life-threatening blood clots (thrombosis).1,2 PNH can affect people of any age, race, or gender.1,2 In PNH, the body’s stem cells acquire a gene mutation which resul...
The Complement System
Просмотров 34 тыс.5 лет назад
The complement system is an important part of the immune system. It is a set of proteins that acts (sometimes in concert with antibodies and white blood cells) to kill germs, destroy unnecessary cells that need to be removed, and to clean up the debris afterward. Through these normal processes, the complement system promotes inflammation.1 The complement system consists of more than 40 proteins...