CTech™ Analytical Solutions
CTech™ Analytical Solutions
  • Видео 59
  • Просмотров 34 325
LIVE from the LAB: FlowVPX + KR2i Connected Systems Showcase
See the FlowVPX® System in action with the KrosFlo KR2i TFF System to monitor and control UFDF by concentration, not weight.
The FlowVPX System harnesses the power of Slope Spectroscopy, which has been a proven technology for over 14 years in the biopharmaceutical industry for accurate and reliable quantification, with global adoption by major biopharma companies.
The FlowVPX system allows in-line process analytics (PAT) which complements the KR2i and larger-scale TFF systems. Rather than using UV sensors simply to monitor filter integrity, the FlowVPX can measure real-time concentration in the retentate line and control the entire process by connecting with the KR2i. Many target analytes c...
Просмотров: 147

Видео

Dilution-free Analytics Tech for Reduced Deviations in Mfg Floor and Multi-site Method (German)25:50Dilution-free Analytics Tech for Reduced Deviations in Mfg Floor and Multi-site Method (German)
Dilution-free Analytics Tech for Reduced Deviations in Mfg Floor and Multi-site Method (German)
Просмотров 115 месяцев назад
Dilution-free Analytics Technology for Reduced Deviations in Manufacturing Floor Analysis and Multi-site Method Alignment - German
Dilution-free Analytics Tech for Reduced Deviations in Mfg Floor and Multi-site Method (Spanish)22:03Dilution-free Analytics Tech for Reduced Deviations in Mfg Floor and Multi-site Method (Spanish)
Dilution-free Analytics Tech for Reduced Deviations in Mfg Floor and Multi-site Method (Spanish)
Просмотров 165 месяцев назад
Dilution-free Analytics Technology for Reduced Deviations in Manufacturing Floor Analysis and Multi-site Method Alignment - Spanish
Dilution-free Analytics Tech for Reduced Deviations in Mfg Floor and Multi-site Method (French)17:01Dilution-free Analytics Tech for Reduced Deviations in Mfg Floor and Multi-site Method (French)
Dilution-free Analytics Tech for Reduced Deviations in Mfg Floor and Multi-site Method (French)
Просмотров 195 месяцев назад
SoloVPE: Dilution-free Analytics Technology for Reduced Deviations in Manufacturing Floor Analysis and Multi-site Method Alignment - French
Realization of PAT inline using Variable Pathlength Spectroscopy-DS mAbs & viral vector purification42:00Realization of PAT inline using Variable Pathlength Spectroscopy-DS mAbs & viral vector purification
Realization of PAT inline using Variable Pathlength Spectroscopy-DS mAbs & viral vector purification
Просмотров 275 месяцев назад
The first and only variable pathlength analysis technology has been integrated in-line with flow paths for PAT use in downstream unit operations. Rapid and accurate real-time results were acquired on the widest range of samples and concentrations (from less than 1 mg/mL to over 300 mg/mL), revealing previously unrecognized process characteristics.
Determination of bacterial growth curve using OD600 and the SoloVPE® Device31:10Determination of bacterial growth curve using OD600 and the SoloVPE® Device
Determination of bacterial growth curve using OD600 and the SoloVPE® Device
Просмотров 825 месяцев назад
Microorganism, such as bacteria like E. coli, have several applications in the biopharma, food, and agriculture industry. Process monitoring and control are of the highest importance in the manufacturing of such microorganisms to allow good product quality when monitoring the growth kinetics of the cells. This limited linear range of traditional UV brings a challenge when adapting optical densi...
How is Variable Pathlength Technology different from traditional UV-Vis analysis?2:47How is Variable Pathlength Technology different from traditional UV-Vis analysis?
How is Variable Pathlength Technology different from traditional UV-Vis analysis?
Просмотров 2447 месяцев назад
Traditionally, photometric analysis relies on a fixed pathlength at a single data point. Locking the pathlength forces us to “unlock” or change the concentration to an acceptable level. This depends on an error-prone process: Transfer of samples offline to the QC lab, dilution of the sample for GMP processing, and resultant manual calculations. Dilutions also vary from analyst to analyst, requi...
What is the difference between SoloVPE and FlowVPX Systems?1:45What is the difference between SoloVPE and FlowVPX Systems?
What is the difference between SoloVPE and FlowVPX Systems?
Просмотров 2097 месяцев назад
Concentration measurement is a key -critical quality attribute at almost every stage of the downstream process either as batch release test or for in-process control. Many functional groups within the biopharma company are dependent on this key measurement to ensure quality and safety through the process, including Quality Control, Analytical Development, Process Development and especially in G...
What is Variable Pathlength Technology (VPT)?2:11What is Variable Pathlength Technology (VPT)?
What is Variable Pathlength Technology (VPT)?
Просмотров 3637 месяцев назад
This UV-Visible-based technology provides more efficient analysis methods for both at-line and in-line concentration measurement processes. The Beer-Lambert's law is reimagined, taking multiple Absorbances at different distances from the detector versus a single Absorbance with traditional UV-Vis spectrophotometer. We omit dilution, estimation, and all manual calculations. The patented Slope Sp...
Accelerating Analytical Testing for GMP Plasmid Production | Variable Pathlength Technology (VPT)26:45Accelerating Analytical Testing for GMP Plasmid Production | Variable Pathlength Technology (VPT)
Accelerating Analytical Testing for GMP Plasmid Production | Variable Pathlength Technology (VPT)
Просмотров 397 месяцев назад
Learn more at www.repligen.com/ The challenges associated with gene therapy bioprocessing are numerous and burdensome, from scalability to Cost of Goods control, and from ensuring quality/consistency to accessing sufficient capacity and expertise. The consensus of opinion in the field is that a largely or fully automated process based upon a single, easy-to-use platform would be optimal, as wou...
Automating UFDF Process w/ In-Line Conc Measurement to Reduce Cycling Time & Accelerate Process Dev32:57Automating UFDF Process w/ In-Line Conc Measurement to Reduce Cycling Time & Accelerate Process Dev
Automating UFDF Process w/ In-Line Conc Measurement to Reduce Cycling Time & Accelerate Process Dev
Просмотров 447 месяцев назад
Learn more at www.repligen.com/ In this presentation, we presented an innovative integrated system designed to automate the tangential flow filtration (TFF) process based on inline concentration measurement. This system employs in-line variable pathlength spectroscopy to acquire concentration measurements, enabling real-time monitoring and control of the process and ensuring desired results. Th...
Validating Protein Concentration of Antibody-Drug Conjugates with Variable Pathlength Spectroscopy45:14Validating Protein Concentration of Antibody-Drug Conjugates with Variable Pathlength Spectroscopy
Validating Protein Concentration of Antibody-Drug Conjugates with Variable Pathlength Spectroscopy
Просмотров 1677 месяцев назад
Learn more at www.repligen.com/ This webinar demonstrates how an assay by the SoloVPE System method was validated to determine the protein concentration of an ADC, proving the technology to be the superior method for this application. Antibody-drug conjugates (ADCs) are complex molecules designed to target and kill tumor cells. ADCs consist of a monoclonal antibody, drug linker, and drug (paylo...
Development & Validation of a Platform Assay Method Using VPT for Oligonucleotide Drug Products33:07Development & Validation of a Platform Assay Method Using VPT for Oligonucleotide Drug Products
Development & Validation of a Platform Assay Method Using VPT for Oligonucleotide Drug Products
Просмотров 857 месяцев назад
Learn more at www.repligen.com/ This webinar will share Ionis’ experience with developing and validating a platform SoloVPE® in-process assay method for GMP manufacturing of oligonucleotide drug products. It will describe how to develop and optimize a method suitable for oligonucleotides, the benefits compared to a previous HPLC method, method validation & transfer to CMOs and utilization of me...
Automating the UFDF Process Using an Integrated TFF System with In-Line Real-Time Conc Measurement11:25Automating the UFDF Process Using an Integrated TFF System with In-Line Real-Time Conc Measurement
Automating the UFDF Process Using an Integrated TFF System with In-Line Real-Time Conc Measurement
Просмотров 1247 месяцев назад
Learn more about the KrosFlo RPM System: www.repligen.com/kr2i-rpm Automating the UFDF Process Using an Integrated TFF System with In-Line Real-Time Concentration Measurement Monitor concentration in real time during your UF/DF run. Featuring in-line protein concentration management, control your process with the power of the KrosFlo® KR2i TFF System and insights from the integrated CTech™ Flow...
Slope Spectroscopy for Gene Therapy Applications | CTech SoloVPE System22:13Slope Spectroscopy for Gene Therapy Applications | CTech SoloVPE System
Slope Spectroscopy for Gene Therapy Applications | CTech SoloVPE System
Просмотров 507 месяцев назад
Learn more at www.repligen.com/ Eliminating time-consuming, error-prone dilution steps can provide multiple benefits, and utilizing the variable pathlength technology (VPT) SoloVPE System can provide: - Rapid time to results - Decreased process development time - Reduced cycling time and increased process efficiency - Strengthened process controls - Increased ability to minimize risk
Case Study: Streamlining AAV Titer Determination Using Variable Pathlength Technology (VPT)57:21Case Study: Streamlining AAV Titer Determination Using Variable Pathlength Technology (VPT)
Case Study: Streamlining AAV Titer Determination Using Variable Pathlength Technology (VPT)
Просмотров 537 месяцев назад
Case Study: Streamlining AAV Titer Determination Using Variable Pathlength Technology (VPT)
GEN-Automated Process Analytical Technology PAT-Driven UFDF Process | KrosFlo RPM System39:22GEN-Automated Process Analytical Technology PAT-Driven UFDF Process | KrosFlo RPM System
GEN-Automated Process Analytical Technology PAT-Driven UFDF Process | KrosFlo RPM System
Просмотров 627 месяцев назад
GEN-Automated Process Analytical Technology PAT-Driven UFDF Process | KrosFlo RPM System
Aldevron Case Study: Validation of mRNA Concentration Determination Using VPT | CTech SoloVPE System1:02:16Aldevron Case Study: Validation of mRNA Concentration Determination Using VPT | CTech SoloVPE System
Aldevron Case Study: Validation of mRNA Concentration Determination Using VPT | CTech SoloVPE System
Просмотров 1187 месяцев назад
Aldevron Case Study: Validation of mRNA Concentration Determination Using VPT | CTech SoloVPE System
Implementation of the SoloVPE Technology for Protein Conc Measurement of Monoclonal Antibodies43:54Implementation of the SoloVPE Technology for Protein Conc Measurement of Monoclonal Antibodies
Implementation of the SoloVPE Technology for Protein Conc Measurement of Monoclonal Antibodies
Просмотров 3137 месяцев назад
Implementation of the SoloVPE Technology for Protein Conc Measurement of Monoclonal Antibodies
CGTI Fast Facts: At- & In-line Concentration Measurements for Process Dev and GMP Manufacturing14:55CGTI Fast Facts: At- & In-line Concentration Measurements for Process Dev and GMP Manufacturing
CGTI Fast Facts: At- & In-line Concentration Measurements for Process Dev and GMP Manufacturing
Просмотров 297 месяцев назад
CGTI Fast Facts: At- & In-line Concentration Measurements for Process Dev and GMP Manufacturing
Accelerate your UFDF Process Using the Only In-Line Concentration Controlled TFF System | RPM System40:33Accelerate your UFDF Process Using the Only In-Line Concentration Controlled TFF System | RPM System
Accelerate your UFDF Process Using the Only In-Line Concentration Controlled TFF System | RPM System
Просмотров 347 месяцев назад
Accelerate your UFDF Process Using the Only In-Line Concentration Controlled TFF System | RPM System
Cell & Gene Therapy Insights Fast Facts: Expediting Downstream Analytical Testing19:14Cell & Gene Therapy Insights Fast Facts: Expediting Downstream Analytical Testing
Cell & Gene Therapy Insights Fast Facts: Expediting Downstream Analytical Testing
Просмотров 208 месяцев назад
Cell & Gene Therapy Insights Fast Facts: Expediting Downstream Analytical Testing
Accelerate Process Development with At-Line Concentration Measurement | CTech SoloVPE System28:15Accelerate Process Development with At-Line Concentration Measurement | CTech SoloVPE System
Accelerate Process Development with At-Line Concentration Measurement | CTech SoloVPE System
Просмотров 368 месяцев назад
Accelerate Process Development with At-Line Concentration Measurement | CTech SoloVPE System
In-Line Concentration Measurement in Biologic Process Development and GMP Manufacturing27:13In-Line Concentration Measurement in Biologic Process Development and GMP Manufacturing
In-Line Concentration Measurement in Biologic Process Development and GMP Manufacturing
Просмотров 348 месяцев назад
In-Line Concentration Measurement in Biologic Process Development and GMP Manufacturing
Revolutionary approach to UV-Vis measurements | CTech SoloVPE Slope Spectroscopy48:23Revolutionary approach to UV-Vis measurements | CTech SoloVPE Slope Spectroscopy
Revolutionary approach to UV-Vis measurements | CTech SoloVPE Slope Spectroscopy
Просмотров 3308 месяцев назад
Revolutionary approach to UV-Vis measurements | CTech SoloVPE Slope Spectroscopy
Bioprocessing Expert Panel Discussion II - PAT Strategies/Variable Pathlength Technology58:26Bioprocessing Expert Panel Discussion II - PAT Strategies/Variable Pathlength Technology
Bioprocessing Expert Panel Discussion II - PAT Strategies/Variable Pathlength Technology
Просмотров 468 месяцев назад
Bioprocessing Expert Panel Discussion II - PAT Strategies/Variable Pathlength Technology
Model Predictive Control for automated biologics drug product manufacturing50:41Model Predictive Control for automated biologics drug product manufacturing
Model Predictive Control for automated biologics drug product manufacturing
Просмотров 638 месяцев назад
Model Predictive Control for automated biologics drug product manufacturing
Biologics concentration measurement with the FlowVPX during the UF/DF process in drug substance mftg55:04Biologics concentration measurement with the FlowVPX during the UF/DF process in drug substance mftg
Biologics concentration measurement with the FlowVPX during the UF/DF process in drug substance mftg
Просмотров 958 месяцев назад
Biologics concentration measurement with the FlowVPX during the UF/DF process in drug substance mftg
Implementing PAT strategy using in-line concentration monitoring in batch/continuous chromatography41:22Implementing PAT strategy using in-line concentration monitoring in batch/continuous chromatography
Implementing PAT strategy using in-line concentration monitoring in batch/continuous chromatography
Просмотров 1078 месяцев назад
Implementing PAT strategy using in-line concentration monitoring in batch/continuous chromatography
Bioprocessing Expert Panel Discussion I - PAT Implementation57:15Bioprocessing Expert Panel Discussion I - PAT Implementation
Bioprocessing Expert Panel Discussion I - PAT Implementation
Просмотров 578 месяцев назад
Bioprocessing Expert Panel Discussion I - PAT Implementation